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Xenobiotica
the fate of foreign compounds in biological systems
Volume 3, 1973 - Issue 4
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Research Article

Azo Reduction of Salicyl-Azo-Sulphapyridine in Germ-free and Conventional Rats

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Pages 225-231 | Received 07 Nov 1972, Published online: 14 Oct 2008

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Yuan Xie, Fangdi Hu, Dawei Xiang, Hui Lu, Wenbin Li, Anpeng Zhao, Longji Huang & Rong Wang. (2020) The metabolic effect of gut microbiota on drugs. Drug Metabolism Reviews 52:1, pages 139-156.
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MarkA. Brown & StephenC. De Vito. (1993) Predicting azo dye toxicity. Critical Reviews in Environmental Science and Technology 23:3, pages 249-324.
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King-Thorn Chung, S. Edward Stevens & Carl E. Cerniglia. (1992) The Reduction of Azo Dyes by the Intestinal Microflora. Critical Reviews in Microbiology 18:3, pages 175-190.
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C.-E. Leijonmarck, P. Benno, B. Carlstedt-Duke, U. Monsen, E. Norin, B. Poppen, H. Saxerholt & T. Midtvedt. (1990) The Function of the Intestinal Microflora in Patients with Ulcerative Colitis before and after Colectomy. Scandinavian Journal of Gastroenterology 25:6, pages 585-593.
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Hasse Schröder & Anna K. Johansson. (1973) Redox Potential in Caecal Contents of the Rat and Azo Reduction of Salicyl-Azo-Sulphapyridine. Xenobiotica 3:4, pages 233-246.
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Articles from other publishers (27)

Lea Gnatzy, George Ismailos, Maria Vertzoni & Christos Reppas. (2023) Managing the clinical effects of drug-induced intestinal dysbiosis with a focus to antibiotics: Challenges and opportunities. European Journal of Pharmaceutical Sciences 188, pages 106510.
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Jana Štofilová, Monika Kvaková, Anna Kamlárová, Emília Hijová, Izabela Bertková & Zuzana Guľašová. (2022) Probiotic-Based Intervention in the Treatment of Ulcerative Colitis: Conventional and New Approaches. Biomedicines 10:9, pages 2236.
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Ana Rita da Silva Ferreira, Anne-Grete Märtson, Alyse de Boer, Hannah R. Wardill, Jan-Willem Alffenaar, Hermie J. M. Harmsen & Wim J. E. Tissing. (2021) Does Chemotherapy-Induced Gastrointestinal Mucositis Affect the Bioavailability and Efficacy of Anti-Infective Drugs?. Biomedicines 9:10, pages 1389.
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Xintong Zhang, Ying Han, Wei Huang, Mingji Jin & Zhonggao Gao. (2021) The influence of the gut microbiota on the bioavailability of oral drugs. Acta Pharmaceutica Sinica B 11:7, pages 1789-1812.
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Yukuang Guo, Hyunwoo Lee & Hyunyoung Jeong. 2020. The Microbiome in Health and Disease. The Microbiome in Health and Disease 61 93 .
Ian D. Wilson & Jeremy K. Nicholson. (2017) Gut microbiome interactions with drug metabolism, efficacy, and toxicity. Translational Research 179, pages 204-222.
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Ian D. Wilson & Jeremy K. Nicholson. 2015. Metabonomics and Gut Microbiota in Nutrition and Disease. Metabonomics and Gut Microbiota in Nutrition and Disease 323 341 .
Steven R. Vigna. (2014) 5-Aminosalicylic Acid Inhibits Acute Clostridium difficile Toxin A-Induced Colitis in Rats . International Journal of Inflammation 2014, pages 1-10.
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Richard B. Silverman & Mark W. Holladay. 2014. The Organic Chemistry of Drug Design and Drug Action. The Organic Chemistry of Drug Design and Drug Action 357 422 .
Richard B. Silverman. 2004. The Organic Chemistry of Drug Design and Drug Action. The Organic Chemistry of Drug Design and Drug Action 405 495 .
Julio Gálvez, Margarita Garrido, Manuel Merlos, Maria Isabel Torres & Antonio Zarzuelo. (2009) Intestinal anti‐inflammatory activity of UR‐12746, a novel 5‐ASA conjugate, on acute and chronic experimental colitis in the rat. British Journal of Pharmacology 130:8, pages 1949-1959.
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Stig Bondesen. (1997) INTESTINAL FATE OF 5-AMINOSALICYLIC ACID: REGIONAL AND SYSTEMIC KINETIC STUDIES IN RELATION TO INFLAMMATORY BOWEL DISEASE. Pharmacology & Toxicology 81, pages 1-30.
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King-Thom Chung. 1997. Gastrointestinal Microbiology. Gastrointestinal Microbiology 511 582 .
L. -G. Axelsson & S. Ahlstedt. (1993) Actions of sulphasalazine and analogues in animal models of experimental colitis. Inflammopharmacology 2:3, pages 219-232.
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M.Abu Shamat. (1993) The role of the gastrointestinal microflora in the metabolism of drugs. International Journal of Pharmaceutics 97:1-3, pages 1-13.
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Richard B. Silverman. 1992. The Organic Chemistry of Drug Design and Drug Action. The Organic Chemistry of Drug Design and Drug Action 277 351 .
George Earl DukesJr.Jr.. 1992. Applied Therapeutics. Applied Therapeutics 397 410 .
Kenneth F. Ilett, Lisa B.G. Tee, Philip T. Reeves & Rodney F. Minchin. (1990) Mebolism of drugs and other xenobiotics in the gut lumen and wall. Pharmacology & Therapeutics 46:1, pages 67-93.
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Hubert Allgayer, Niels O. Ahnfelt, Wolfgang Kruis, Ulrich Klotz, Katharina Frank-Holmberg, Hellmut N.A. Söderberg & Gustav Paumgartner. (1989) Colonic N-acetylation of 5-aminosalicylic acid in inflammatory bowel disease. Gastroenterology 97:1, pages 38-41.
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J. R. S. Hoult. 1987. Side-Effects of Anti-Inflammatory Drugs. Side-Effects of Anti-Inflammatory Drugs 223 234 .
IAN R. ROWLAND. 1986. Bioreduction in the Activation of Drugs. Bioreduction in the Activation of Drugs 27 32 .
Ian R. Rowland. (1986) Reduction by the gut microflora of animals and man. Biochemical Pharmacology 35:1, pages 27-32.
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J. R. S. Hoult & P. K. Moore. 1982. Inflammatory Bowel Diseases. Inflammatory Bowel Diseases 174 189 .
Henry J. Pieniaszek & Theodore R. Bates. (1979) Capacity-limited Gut Wall Metabolism of 5-aminosalicylic acid, a Therapeutically Active Metabolite of Sulfasalazine, in Rats. Journal of Pharmaceutical Sciences 68:10, pages 1323-1325.
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G. C. Bolton & L. A. Griffiths. (1978) Metabolism of hydrazines and hydrazides by the intestinal microflora. Experientia 34:11, pages 1484-1486.
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Peter Goldman & Mark A. Peppercorn. (1975) Sulfasalazine. New England Journal of Medicine 293:1, pages 20-23.
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B. West, R. Lendrum, M. J. Hill & G. Walker. (1974) Effects of sulphasalazine (Salazopyrin) on faecal flora in patients with inflammatory bowel disease. Gut 15:12, pages 960-965.
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