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Xenobiotica
the fate of foreign compounds in biological systems
Volume 3, 1973 - Issue 6
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Research Article

The Absorption of Nicotine-1′-N-Oxide and its Reduction in the Gastro-Intestinal Tract in Man

P. Jenner Pharmacy Department, Chelsea College, University of London, Manresa Road, London, SW3, England; Department of Neurology, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, SE5 8AF, England
,
J. W. Gorrod Pharmacy Department, Chelsea College, University of London, Manresa Road, London, SW3, England
&
A. H. Beckett Pharmacy Department, Chelsea College, University of London, Manresa Road, London, SW3, England
Pages 341-349 | Received 22 Sep 1972, Published online: 14 Oct 2008

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M. NAKAJIMA, K. IWATA, T. YOSHIDA, T. YAMAMOTO & Y. KUROIWA. (1998) Diastereospecific kinetics of nicotine N-oxidation in rat liver microsomes. Xenobiotica 28:2, pages 127-134.
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T. J. Jaworski, E. M. Hawes, G. McKay & K. K. Midha. (1990) The metabolism of chlorpromazine N-oxide in man and dog. Xenobiotica 20:1, pages 107-115.
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DanielW. Sepkovic, NancyJ. Haley, CarynM. Axelrad, Akemi Shigematsu & EdmondJ. LaVoie. (1986) Short‐term studies on the in vivo metabolism of N‐oxides of nicotine in rats. Journal of Toxicology and Environmental Health 18:2, pages 205-214.
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Susumu Maeda, Setsuko Uchida & Takuro Kisaki. (1978) Microbial Degradation of Nicotine-N′-oxide I Degradation Products. Agricultural and Biological Chemistry 42:8, pages 1455-1460.
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M. A. H. Russell & C. Feyerabend. (1978) Cigarette Smoking: A Dependence on High-Nicotine Boli. Drug Metabolism Reviews 8:1, pages 29-57.
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P. L. Gigon. (1975) Effect of Diphenylhydantoin on the Biotransformation and Biliary Excretion of Impramine in Rats. Xenobiotica 5:10, pages 585-594.
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Articles from other publishers (26)

Masato Miyauchi, Shinkichi Ishikawa, Takeshi Kurachi, Kazutami Sakamoto & Hideki Sakai. (2022) Oral Absorption across Organotypic Culture Models of the Human Buccal Epithelium after E-cigarette Aerosol Exposure. ACS Omega.
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Sophia Barhdadi, Goedele Moens, Michael Canfyn, Celine Vanhee, Bart Desmedt, Patricia Courselle, Vera Rogiers, Tamara Vanhaecke & Eric Deconinck. (2021) Impact of the Revised European Tobacco Product Directive on the Quality of E-cigarette Refill Liquids in Belgium. Nicotine & Tobacco Research 23:1, pages 227-234.
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Christine Müller, Franziska S. Birmes, Heiko Niewerth & Susanne Fetzner. (2014) Conversion of the Pseudomonas aeruginosa Quinolone Signal and Related Alkylhydroxyquinolines by Rhodococcus sp. Strain BG43. Applied and Environmental Microbiology 80:23, pages 7266-7274.
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Dariusz Pogocki, Tomasz Ruman, Magdalena Danilczuk, Marek Danilczuk, Monika Celuch & Elżbieta Wałajtys-Rode. (2007) Application of nicotine enantiomers, derivatives and analogues in therapy of neurodegenerative disorders. European Journal of Pharmacology 563:1-3, pages 18-39.
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Riley A. Davis & Margareta Curvali. 1999. Analytical Determination of Nicotine and Related Compounds and their Metabolites. Analytical Determination of Nicotine and Related Compounds and their Metabolites 583 643 .
John W. Gorrod & Georg Schepers. 1999. Analytical Determination of Nicotine and Related Compounds and their Metabolites. Analytical Determination of Nicotine and Related Compounds and their Metabolites 45 67 .
C. Giachetti, A. Assandri, G. Mautone, E. Tajana, B. Palumbo & R. Palumbo. (1996) Pharmacokinetics and metabolism of N-(2-hydroxyethyl)-2,5-[14C]-pyrrolidine (HEP, Epolamine) in male healthy volunteers. European Journal of Drug Metabolism and Pharmacokinetics 21:3, pages 261-268.
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G. Lin, G. McKay & K.K. Midha. (1996) Characterization of metabolites of clozapine N-oxide in the rat by micro-column high performance liquid chromatography/mass spectrometry with electrospray interface. Journal of Pharmaceutical and Biomedical Analysis 14:11, pages 1561-1577.
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SE Atawodi & E. Richter. (2016) Bacterial reduction of N-oxides of tobacco- specific nitrosamines (TSNA). Human & Experimental Toxicology 15:4, pages 329-334.
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Dani Matsushima, Mary E. Prevo & Jane Gorsline. (1995) Absorption and Adverse Effects following Topical and Oral Administration of Three Transdermal Nicotine Products to Dogs. Journal of Pharmaceutical Sciences 84:3, pages 365-369.
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G. Schepers, K. Rustemeier, R. -A. Walk & U. Hackenberg. (1993) Metabolism of S-nicotine in noninduced and aroclor-induced rats. European Journal of Drug Metabolism and Pharmacokinetics 18:2, pages 187-197.
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S. Cholerton, N. W. McCracken & J. R. Idle. 1993. Nicotine and Related Alkaloids. Nicotine and Related Alkaloids 219 254 .
E. M. Hawes, T. J. Jaworski, K. K. Midha, G. McKay, J. W. Hubbard & E. D. Korchinski. 1991. N-Oxidation of Drugs. N-Oxidation of Drugs 263 286 .
L. A. Damani. 1991. N-Oxidation of Drugs. N-Oxidation of Drugs 239 261 .
Karl-Heinz BeyerKarl-Heinz Beyer. 1990. Biotransformation der Arzneimittel. Biotransformation der Arzneimittel 385 387 .
Murray E. Jarvik & Jack E. Henningfield. (1988) Pharmacological treatment of tobacco dependence. Pharmacology Biochemistry and Behavior 30:1, pages 279-294.
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Neal L. Benowitz & Peyton JacobIIIIII. 1987. Tobacco Smoking and Nicotine. Tobacco Smoking and Nicotine 357 373 .
Peter A.G.M. de Smet & Nicholas M. Hellmuth. (1986) A multidisciplinary approach to ritual enema scenes on ancient Maya pottery. Journal of Ethnopharmacology 16:2-3, pages 213-262.
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Neal L. Benowitz. 1986. Research Advances in Alcohol and Drug Problems. Research Advances in Alcohol and Drug Problems 1 52 .
Keith S. Rotenberg & Joseph Adir. (1983) Pharmacokinetics of nicotine in rats after multiple-cigarette smoke exposure. Toxicology and Applied Pharmacology 69:1, pages 1-11.
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Andrew G. Renwick, Susan P. Evans, Trevor W. Sweatman, Janet Cumberland & Charles F. George. (1982) The role of the gut flora in the reduction of sulphinpyrazone in the rat. Biochemical Pharmacology 31:16, pages 2649-2656.
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D.S. HEWICK. 1982. Metabolic Basis of Detoxication. Metabolic Basis of Detoxication 151 170 .
A. E. Klein & J. W. Gorrod. (1978) Age as a factor in the metabolism of nicotine. European Journal of Drug Metabolism and Pharmacokinetics 3:1, pages 51-58.
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David J. Temple. (2006) The Absorption of Nicotine from Tobacco Snuff through the Nasal Mucosa. Archiv der Pharmazie 309:12, pages 984-987.
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J.W. GORROD & P. JENNER. 1975. 35 78 .
Allen K. Herd & John K. Haleblian. (1974) Pharmaceutical Sciences — 1973: Literature Review of Pharmaceutics. Journal of Pharmaceutical Sciences 63:7, pages 995-1055.
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