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Xenobiotica
the fate of foreign compounds in biological systems
Volume 3, 1973 - Issue 9
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Research Article

Factors Affecting the in vitro Metabolism of R-(+)-and S-(-)-Nicotine by Guinea-pig Liver Preparations

P. Jenner Department of Pharmacy, Chelsea College (University of London), Manresa Road, London, SW3, UK
,
J. W. Gorrod Department of Pharmacy, Chelsea College (University of London), Manresa Road, London, SW3, UK
&
A. H. Beckett Department of Pharmacy, Chelsea College (University of London), Manresa Road, London, SW3, UK
Pages 563-572 | Received 25 Jan 1973, Published online: 14 Oct 2008

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M. NAKAJIMA, K. IWATA, T. YOSHIDA, T. YAMAMOTO & Y. KUROIWA. (1998) Diastereospecific kinetics of nicotine N-oxidation in rat liver microsomes. Xenobiotica 28:2, pages 127-134.
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Gabriel A. Kyerematen & Elliot S. Vesell. (1991) Metabolism of Nicotine. Drug Metabolism Reviews 23:1-2, pages 3-41.
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C. G. Nwosu & P. A. Crooks. (1988) Species Variation and Stereoselectivity in the Metabolism of Nicotine Enantiomers. Xenobiotica 18:12, pages 1361-1372.
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DanielW. Sepkovic, NancyJ. Haley, CarynM. Axelrad, Akemi Shigematsu & EdmondJ. LaVoie. (1986) Short‐term studies on the in vivo metabolism of N‐oxides of nicotine in rats. Journal of Toxicology and Environmental Health 18:2, pages 205-214.
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Peter Hlavica & John W. Gorrod. (1982) Biological Oxidation of Nitrogen in Organic Compounds and Disposition of N-Oxidized Product. Critical Reviews in Biochemistry 12:1, pages 39-101.
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A. L. Misra, R. B. Pontani & N. L. Vadlamani. (1979) Metabolism of norcocaine, N-hydroxy norcocaine and cocaine-N-oxide in the rat. Xenobiotica 9:3, pages 189-199.
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Bernard Testa, Peter Jenner, Arnold H. Beckett & John W. Gorrod. (1976) A Reappraisal of the Stereoselective Metabolism of Nicotine to Nicotine-l'-N-oxide. Xenobiotica 6:9, pages 553-556.
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P. Jenner & B. Testa. (1974) The Influence of Stereochemical Factors on Drug Disposition. Drug Metabolism Reviews 2:1, pages 117-184.
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P. Jenner, J. W. Gorrod & A. H. Beckett. (1973) Species Variation in the Metabolism of R-(+)- and S-(-)-Nicotine by α-C- and N-Oxidation in vitro. Xenobiotica 3:9, pages 573-580.
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A. H. Beckett, P. Jenner & J. W. Gorrod. (1973) Characterization of the Diastereoisomers of Nicotine-1′-N-Oxide, a Metabolite of Nicotine, and Other Possible Oxidation Products by Nuclear Magnetic Resonance Spectroscopy. Xenobiotica 3:9, pages 557-562.
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Articles from other publishers (18)

Bethany G. Hoegberg, Ermelinda Lomazzo, Norman H. Lee & David C. Perry. (2015) Regulation of ?4?2?5 nicotinic acetylcholinergic receptors in rat cerebral cortex in early and late adolescence: Sex differences in response to chronic nicotine. Neuropharmacology 99, pages 347-355.
Crossref
John Cashman. 1999. Handbook of Drug Metabolism. Handbook of Drug Metabolism 477 505 .
Mui C. Tsai & John W. Gorrod. 1999. Analytical Determination of Nicotine and Related Compounds and their Metabolites. Analytical Determination of Nicotine and Related Compounds and their Metabolites 645 668 .
N. CastagnoliJr.Jr., M. Shigenaga, T. Carlson, W. F. Trager & A. Trevor. 1991. Effects of Nicotine on Biological Systems. Effects of Nicotine on Biological Systems 25 34 .
Gabriel A. Kyerematen, Monica Morgan, Genevieve Warner, Louis F. Martin & Elliot S. Vesell. (1990) Metabolism of nicotine by hepatocytes. Biochemical Pharmacology 40:8, pages 1747-1756.
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G.David McCoy, George J. Demarco & Dennis R. Koop. (1989) Microsomal nicotine metabolism: A comparison of relative activities of six purified rabbit cytochrome P-450 isozymes. Biochemical Pharmacology 38:7, pages 1185-1188.
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Peyton JacobIIIIII, Neal L. Benowitz, James R. Copeland, Marcus E. Risner & Edward J. Cone. (1988) Disposition Kinetics of Nicotine and Cotinine Enantiomers in Rabbits and Beagle Dogs. Journal of Pharmaceutical Sciences 77:5, pages 396-400.
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David R. Webb, Vijendra KR. Singh, H. Hugh Fudenberg, Roger W. Russell, L. Öhman, G. Maluszynska, K.-E. MAgnusson, O. Stendahl, Peter A. Lambert, David H. P. Streeten, Gunnar H. AndersonJrJr, Vickram Ramkumar, George Pierson, Gary L. Stiles, Bernard Testa, Joachm M. Mayer, Duncan Stewart-Tull, Michael Williams, Gary L. Niel, Peter Hambleton, Stephen D. Prior, Andrew Robinson, Jed F. Fisher & Paul A. AristoffBernard Testa & Joachim M. Mayer. 1988. Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques. Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques 249 303 .
G.David McCoy & George J. DeMarco. (1986) Characterization of hamster liver nicotine metabolism?II. Differential effects of ethanol or phenobarbital pretreatment on microsomal N and C oxidation. Biochemical Pharmacology 35:24, pages 4590-4592.
Crossref
John A. Thompson, Kenneth J. Norris & Dennis R. Petersen. (1985) Isolation and analysis of N-oxide metabolites of tertiary amines: Quantitation of nicotine-1′-N-oxide formation in mice. Journal of Chromatography B: Biomedical Sciences and Applications 341, pages 349-359.
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K.C. Cundy & P.A. Crooks. (1983) Unexpected pehnomenon in the high-performance liquid chromatographic anlaysis of racemic 14C-labelled nicotine: Separation of enantiomers in a totally achiral system. Journal of Chromatography A 281, pages 17-33.
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J. W. Gorrod & A. R. Hibberd. (1982) The metabolism of nicotine-Δ1′(5′)-iminium ion,in vivo andin vitro. European Journal of Drug Metabolism and Pharmacokinetics 7:4, pages 293-298.
Crossref
L.A. DAMANI & P.A. CROOKS. 1982. Metabolic Basis of Detoxication. Metabolic Basis of Detoxication 69 89 .
R. Forster, M.H.L. Green, A. Priestley & J.W. Gorrod. (1981) Apparent activation of 2-acetylaminofluorene and some aromatic amines by cytosolic preparations. Mutation Research/Environmental Mutagenesis and Related Subjects 85:4, pages 187-194.
Crossref
Trevor RobinsonTrevor Robinson. 1981. The Biochemistry of Alkaloids. The Biochemistry of Alkaloids 166 181 .
Arun P. Kulkarni & Ernest Hodgson. (1980) Metabolism of insecticides by mixed function oxidase systems. Pharmacology & Therapeutics 8:2, pages 379-475.
Crossref
Gerald M. Rosen & Elmer J. Rauckman. (1977) Formation and reduction of a nitroxide radical by liver microsomes. Biochemical Pharmacology 26:7, pages 675-678.
Crossref
J.W. GORROD & P. JENNER. 1975. 35 78 .

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