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Xenobiotica
the fate of foreign compounds in biological systems
Volume 3, 1973 - Issue 10
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Research Article

Behavioural Changes in Primates and Diazepam Metabolism

Claude B. Coutinho Depts. of Clinical Pharmacology and Pharmacology, Hoffmann-La Roche, Inc, Nutley, New Jersey, 07110, USA; Department of Biochemistry and Drug Metabolism
,
Joyce A. Cheripko Depts. of Clinical Pharmacology and Pharmacology, Hoffmann-La Roche, Inc, Nutley, New Jersey, 07110, USA; Department of Biochemistry and Drug Metabolism
,
John J. Carbone Depts. of Clinical Pharmacology and Pharmacology, Hoffmann-La Roche, Inc, Nutley, New Jersey, 07110, USA; Department of Biochemistry and Drug Metabolism
,
John E. Manning Depts. of Clinical Pharmacology and Pharmacology, Hoffmann-La Roche, Inc, Nutley, New Jersey, 07110, USA; Department of Animal Health Services
&
Edward Boff Depts. of Clinical Pharmacology and Pharmacology, Hoffmann-La Roche, Inc, Nutley, New Jersey, 07110, USA; Department of Pharmacology
Pages 681-690 | Received 13 Mar 1973, Published online: 14 Oct 2008

Citations (7)

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Noriaki Sakai & Mayumi Ishizuka. (2009) Impact of rat P450 genetic polymorphism on diazepam metabolism. Expert Opinion on Drug Metabolism & Toxicology 5:11, pages 1421-1433.
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R. Girkin, G. A. Baldock, L. F. Chasseaud, M. Hümpel, D. R. Hawkins & B. C. Mayo. (1980) The absorption, distribution and excretion of [14C]lormetazepam in dogs, rabbits, rats and rhesus monkeys. Xenobiotica 10:6, pages 401-411.
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H. Kitagawa, Y. Esumi, S. Kurosawa, S. Sekine & T. Yokoshima. (1979) Metabolism of 8-chloro-6-(o-chlorophenyl)-1-methyl-4H-s-triazolo [4,3-a] [1,4]benzodiazepine, triazolam, a new central depressant. II. Identification and determination of metabolites in rats and dogs. Xenobiotica 9:7, pages 429-439.
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Articles from other publishers (4)

B Goodwin. 2004. Handbook of Biotransformations of Aromatic Compounds. Handbook of Biotransformations of Aromatic Compounds 213 566 .
Tom Seddon, Graham F. Lockwood & Richard J. Chenery. (1989) in vitro drug metabolism and pharmacokinetics of Diazepam in cynomolgus monkey hepatocytes during culture for six days. Biochemical Pharmacology 38:16, pages 2621-2630.
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Tom Seddon, Ian Michelle & Richard J. Chenery. (1989) Comparative drug metabolism of diazepam in hepatocytes isolated from man, rat, monkey and dog. Biochemical Pharmacology 38:10, pages 1657-1665.
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John M. Clifford. (1977) Drug disposition and effect in sub-human primates used in pharmacology. Comparative Biochemistry and Physiology Part C: Comparative Pharmacology 57:1, pages 1-15.
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