Citations (145)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (6)
Y. Hu, S. S. Dehal, G. Hynd, G. B. Jones & D. Kupfer. (2003) CYP2D6-mediated catalysis of tamoxifen aromatic hydroxylation with an NIH shift: similar hydroxylation mechanism in chicken, rat and human liver microsomes. Xenobiotica 33:2, pages 141-151.
Read now
Read now
Lewis L. Smith, Karen Brown, Philip Carthew, Chang-Kee Lim, Elizabeth A. Martin, Jerry Styles & Ian N. H. White. (2000) Chemoprevention of Breast Cancer by Tamoxifen: Risks and Opportunities. Critical Reviews in Toxicology 30:5, pages 571-594.
Read now
Read now
Bruce Clark, Dennis A. Smith & John Caldwell. (1984) Pharmacokinetics and Toxicity Testing. CRC Critical Reviews in Toxicology 12:4, pages 343-385.
Read now
Read now
L.A. Sternson, N. Meltzer & F.M. H. Shih. (1981) Analysis of Tamoxifen and Its N-Desmethyl and 4-Hydroxy Metabolites in Tissue. Analytical Letters 14:8, pages 583-600.
Read now
Read now
V. Craig Jordan, CliveJ. Dix, KarenE. Naylor, Graham Prestwich & Linda Rowsby. (1978) Nonsteroidal antiestrogens: Their biological effects and potential mechanisms of action. Journal of Toxicology and Environmental Health 4:2-3, pages 363-390.
Read now
Read now
John M. Fromson, Stuart Pearson & Sara Bramah. (1973) The Metabolism of Tamoxifen (I.C.I. 46,474) Part II: In Female Patients. Xenobiotica 3:11, pages 711-714.
Read now
Read now
Articles from other publishers (139)
Alexander M. Scherbakov, Svetlana K. Vorontsova, Alvina I Khamidullina, Jasminka Mrdjanovic, Olga E. Andreeva, Fedor B. Bogdanov, Diana I. Salnikova, Vladimir Jurisic, Igor V. Zavarzin & Valerii Z. Shirinian. (2023) Novel pentacyclic derivatives and benzylidenes of the progesterone series cause anti-estrogenic and antiproliferative effects and induce apoptosis in breast cancer cells. Investigational New Drugs 41:1, pages 142-152.
Crossref
Crossref
V. Craig Jordan. 2022. Tamoxifen Tales. Tamoxifen Tales
47
65
.
V. Craig Jordan. (2021) Turning scientific serendipity into discoveries in breast cancer research and treatment: a tale of PhD students and a 50-year roaming tamoxifen team. Breast Cancer Research and Treatment 190:1, pages 19-38.
Crossref
Crossref
Thomas Helland, Sarah Alsomairy, Chenchia Lin, Håvard Søiland, Gunnar Mellgren & Daniel Louis Hertz. (2021) Generating a Precision Endoxifen Prediction Algorithm to Advance Personalized Tamoxifen Treatment in Patients with Breast Cancer. Journal of Personalized Medicine 11:3, pages 201.
Crossref
Crossref
Gonzalo Gajardo, Rodrigo López-Muñoz, Anita Plaza, Benjamin Uberti, José Sarmiento, Gabriel Morán & Claudio Henríquez. (2019) Tamoxifen in horses: pharmacokinetics and safety study. Irish Veterinary Journal 72:1.
Crossref
Crossref
Jinxu Liu, Gajanan P. Shelkar, Fabao Zhao, Rasmus P. Clausen & Shashank M. Dravid. (2019) Modulation of Burst Firing of Neurons in Nucleus Reticularis of the Thalamus by GluN2C-Containing NMDA Receptors. Molecular Pharmacology 96:2, pages 193-203.
Crossref
Crossref
Mahmud Hasan, Mohamed Akmal Marzouk, Saugat Adhikari, Thomas D. Wright, Benton P. Miller, Margarite D. Matossian, Steven Elliott, Maryl Wright, Madlin Alzoubi, Bridgette M. Collins-Burow, Matthew E. Burow, Ulrike Holzgrabe, Darius P. Zlotos, Robert E. Stratford & Paula A. Witt-Enderby. (2019) Pharmacological, Mechanistic, and Pharmacokinetic Assessment of Novel Melatonin-Tamoxifen Drug Conjugates as Breast Cancer Drugs. Molecular Pharmacology 96:2, pages 272-296.
Crossref
Crossref
Nancy L. Wayne, Sandra Duarte-Vogel, Stacey Kraemer & Joseph D. Rager. (2019) Exposure assessment of laboratory workers to hazardous waste from mice treated with tamoxifen and bromodeoxyuridine. Journal of Chemical Health & Safety 26:1, pages 2-8.
Crossref
Crossref
Balkees Abderrahman & V. Craig Jordan. 2019. Estrogen Receptor and Breast Cancer. Estrogen Receptor and Breast Cancer
189
213
.
Balkees Abderrahman & V. Craig Jordan. 2019. Estrogen Receptor and Breast Cancer. Estrogen Receptor and Breast Cancer
151
188
.
Sarah R. Mikelman, Bipasha Guptaroy, Kyle C. Schmitt, Kymry T. Jones, Juan Zhen, Maarten E. A. Reith & Margaret E. Gnegy. (2018) Tamoxifen Directly Interacts with the Dopamine Transporter. Journal of Pharmacology and Experimental Therapeutics 367:1, pages 119-128.
Crossref
Crossref
Morten M. Callesen, Sigrid S. Árnadóttir, Iben Lyskjaer, Mai-Britt W. Ørntoft, Søren Høyer, Frederik Dagnaes-Hansen, Ying Liu, Rong Li, Henrik Callesen, Mads H. Rasmussen, Martin F. Berthelsen, Martin K. Thomsen, Pawel J. Schweiger, Kim B. Jensen, Søren Laurberg, Torben F. Ørntoft, Jannik E. Elverløv-Jakobsen & Claus L. Andersen. (2017) A genetically inducible porcine model of intestinal cancer. Molecular Oncology 11:11, pages 1616-1629.
Crossref
Crossref
David Castillo-Azofeifa, Justin T. Losacco, Ernesto Salcedo, Erin J. Golden, Thomas E. Finger & Linda A. Barlow. (2017) Sonic hedgehog from both nerves and epithelium is a key trophic factor for taste bud maintenance. Development 144:17, pages 3054-3065.
Crossref
Crossref
Maria Flynn, Kali Amelia Heale & Laleh Alisaraie. (2017) Mechanism of Off-Target Interactions and Toxicity of Tamoxifen and Its Metabolites. Chemical Research in Toxicology 30:7, pages 1492-1507.
Crossref
Crossref
Lesley J. Mills, W. Matthew Henderson, Saro Jayaraman, Ruth E. Gutjahr-Gobell, Gerald E. Zaroogian, Doranne Borsay Horowitz & Susan C. Laws. (2016) Approaches for predicting effects of unintended environmental exposure to an endocrine active pharmaceutical, tamoxifen. Environmental Toxicology 31:12, pages 1834-1850.
Crossref
Crossref
V. C. Jordan. (2014) Tamoxifen as the first targeted long-term adjuvant therapy for breast cancer. Endocrine Related Cancer 21:3, pages R235-R246.
Crossref
Crossref
Philipp Y. Maximov, Russell E. McDaniel & V. Craig JordanPhilipp Y. Maximov, Russell E. McDaniel & V. Craig Jordan. 2013. Tamoxifen. Tamoxifen
47
67
.
Philipp Y. Maximov, Russell E. McDaniel & V. Craig JordanPhilipp Y. Maximov, Russell E. McDaniel & V. Craig Jordan. 2013. Tamoxifen. Tamoxifen
31
46
.
Nilesh W. Gaikwad & William J. Bodell. (2012) Peroxidase-mediated dealkylation of tamoxifen, detected by electrospray ionization–mass spectrometry, and activation to form DNA adducts. Free Radical Biology and Medicine 52:2, pages 340-347.
Crossref
Crossref
C. Gómez, O.J. Pozo, R. Diaz, J.V. Sancho, E. Vilaroca, J.P. Salvador, M.P. Marco, F. Hernandez, J. Segura & R. Ventura. (2011) Mass spectrometric characterization of urinary toremifene metabolites for doping control analyses. Journal of Chromatography A 1218:29, pages 4727-4737.
Crossref
Crossref
Denise Poisson, Antoine Dupuis, Michel Breteau, Serge Bouquet, Marc Poterre & William Couet. (1997) Effect of Tamoxifen on the Pharmacokinetics of Theophylline in Rats. Journal of Pharmacy and Pharmacology 49:1, pages 40-42.
Crossref
Crossref
Paula I. Moreira, José B.A. Custódio, Elsa Nunes, Paulo J. Oliveira, António Moreno, Raquel Seiça, Catarina R. Oliveira & Maria S. Santos. (2011) Mitochondria from distinct tissues are differently affected by 17β-estradiol and tamoxifen. The Journal of Steroid Biochemistry and Molecular Biology 123:1-2, pages 8-16.
Crossref
Crossref
S.F. Teunissen, H. Rosing, A.H. Schinkel, J.H.M. Schellens & J.H. Beijnen. (2010) Bioanalytical methods for determination of tamoxifen and its phase I metabolites: A review. Analytica Chimica Acta 683:1, pages 21-37.
Crossref
Crossref
Donald J. AbrahamPeter C. Ruenitz. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery
219
264
.
Jinsong Ni, Hui Ouyang, Carmai Seto, Takeo Sakuma, Robert Ellis, Josh Rowe, Andrew Acheampong, Devin Welty & Gabriella Szekely-Klepser. (2010) Sensitivity and proportionality assessment of metabolites from microdose to high dose in rats using LC–MS/MS. Bioanalysis 2:3, pages 407-419.
Crossref
Crossref
Yvonne P. Dragan & Henry C. Pitot. 2009. Hormone Therapy in Breast and Prostate Cancer. Hormone Therapy in Breast and Prostate Cancer
83
131
.
Cora J Fong, Lyle D Burgoon, Kurt J Williams, Agnes L Forgacs & Timothy R Zacharewski. (2007) Comparative temporal and dose-dependent morphological and transcriptional uterine effects elicited by tamoxifen and ethynylestradiol in immature, ovariectomized mice. BMC Genomics 8:1.
Crossref
Crossref
Charles M. Buchanan, Norma L. Buchanan, Kevin J. Edgar, James L. Little, Michael O. Malcolm, Karen M. Ruble, Vincent J. Wacher & Michael F. Wempe. (2007) Pharmacokinetics of Tamoxifen after Intravenous and Oral Dosing of Tamoxifen–Hydroxybutenyl-β-Cyclodextrin Formulations. Journal of Pharmaceutical Sciences 96:3, pages 644-660.
Crossref
Crossref
V.C. Jordan. 2007. Comprehensive Medicinal Chemistry II. Comprehensive Medicinal Chemistry II
83
102
.
Hidetoshi Yamaya, Mayuko Saeki, Ken-ichiro Yoshida, Jiro Shibata, Shingo Yano, Yoshiaki Sato, Atsushi Takao, Takashi Shindo, Aman U. Buzdar & Sekio Nagayama. (2006)
DISTRIBUTION OF (7α)-21-[4-[(DIETHYLAMINO) METHYL]-2-METHOXYPHENOXY]-7-METHYL-19-NORPREGNA-1,3,5(10)-TRIEN-3-OL-20-[
14
C]2-HYDROXY-1,2,3-PROPANETRICARBOXYLATE ([
14
C]TAS-108) AND ITS METABOLITES AFTER SINGLE ORAL ADMINISTRATION TO RATS BEARING 7,12-DIMETHYLBENZ(α)ANTHRACENE-INDUCED MAMMARY TUMOR
. Drug Metabolism and Disposition 34:2, pages 331-338.
Crossref
Crossref
Kyung-Hoon Lee, Bryan A. Ward, Zeruesenay Desta, David A. Flockhart & David R. Jones. (2003) Quantification of tamoxifen and three metabolites in plasma by high-performance liquid chromatography with fluorescence detection: application to a clinical trial. Journal of Chromatography B 791:1-2, pages 245-253.
Crossref
Crossref
Chitra Sridar, Ute M. Kent, Lisa M. Notley, Elizabeth M. J. Gillam & Paul F. Hollenberg. (2002) Effect of Tamoxifen on the Enzymatic Activity of Human Cytochrome CYP2B6. Journal of Pharmacology and Experimental Therapeutics 301:3, pages 945-952.
Crossref
Crossref
Joan Riley, Jerry Styles, Richard D Verschoyle, Lesley A Stanley, Ian N.H White & Timothy W Gant. (2000) Association of tamoxifen biliary excretion rate with prior tamoxifen exposure and increased mdr1b expression. Biochemical Pharmacology 60:2, pages 233-239.
Crossref
Crossref
E.A. Lien & P.E. Lønning. (2000) Selective oestrogen receptor modifiers (SERMs) and breast cancer therapy. Cancer Treatment Reviews 26:3, pages 205-227.
Crossref
Crossref
C. Geraldine M. Jordan, K. Brown, C. Beedham & J.E. Brown. (1999) EFFECT OF INHIBITORS ON THE BIOTRANSFORMATION OF TAMOXIFEN BY FEMALE RAT AND MOUSE LIVER SLICES AND HOMOGENATES. Drug Metabolism and Drug Interactions 15:4.
Crossref
Crossref
David J. Boocock, James L. Maggs, Ian N.H. White & B. Kevin Park. (1999) α-Hydroxytamoxifen, a genotoxic metabolite of tamoxifen in the rat: identification and quantification in vivo and in vitro. Carcinogenesis 20:1, pages 153-160.
Crossref
Crossref
Suprabhat Ray & Indra Dwivedy. 1997.
171
270
.
Okezie I. Aruoma. (1996) Characterization of drugs as antioxidant prophylactics. Free Radical Biology and Medicine 20:5, pages 675-705.
Crossref
Crossref
R.M. Jones, Z.-X. Yuan, J.H. Lamb & C.K. Lim. (1996) On-line high-performance liquid chromatographic- electrospray ionization mass spectrometric method for the study of tamoxifen metabolism. Journal of Chromatography A 722:1-2, pages 249-255.
Crossref
Crossref
Markku Ahotupa. 1996. Tamoxifen. Tamoxifen
303
320
.
Stephen R. D. Johnston & Mitchell Dowsett. 1996. Tamoxifen. Tamoxifen
231
266
.
Toshiyuki Toko, Jiro Shibata, Yoshikazu Sugimoto, Hidetoshi Yamaya, Masahiko Yoshida, Kazuo Ogawa & Eiji Matsushima. (1995) Comparative pharmacodynamic analysis of TAT-59 and tamoxifen in rats bearing DMBA-induced mammary carcinoma. Cancer Chemotherapy and Pharmacology 37:1-2, pages 7-13.
Crossref
Crossref
Y. Tanaka, M. Sekiguchi, T. Sawamoto, T. Hata, Y. Esumi, S. Sugai & S. Ninomiya. (1994) Pharmacokinetics of droloxifene in mice, rats, monkeys, premenopausal and postmenopausal patients. European Journal of Drug Metabolism and Pharmacokinetics 19:1, pages 47-58.
Crossref
Crossref
. (1994) Clinical development plan: Tamoxifen. Journal of Cellular Biochemistry 56:S20, pages 252-267.
Crossref
Crossref
Surinder K. Chander, Surinder S. Sahota, Thomas R.J. Evans & Yunus A. Luqmani. (1993) The biological evaluation of novel antioestrogens for the treatment of breast cancer. Critical Reviews in Oncology/Hematology 15:3, pages 243-269.
Crossref
Crossref
Valerie J. Wiebe, C.Kent Osborne, Suzanne A.W. Fuqua & Michael W. DeGregorio. (1993) Tamoxifen resistance in breast cancer. Critical Reviews in Oncology/Hematology 14:3, pages 173-188.
Crossref
Crossref
William S. Branham, Beverly D. Lyn-Cook, Annette Andrews & Daniel M. Sheehan. (1993) Growth of separated and recombined neonatal rat uterine luminal epithelium and stroma on extracellular matrix: Effects of in vivo tamoxifen exposure. In Vitro Cellular & Developmental Biology - Animal 29:5, pages 408-414.
Crossref
Crossref
Lan N.H. White, Adrian Davies, Lewis L. Smith, Sally Dawson & Francesco de Matteis. (1993) Induction of CYP2B1 and 3A1, and associated monooxygenase activities by tamoxifen and certain analogues in the livers of female rats and mice. Biochemical Pharmacology 45:1, pages 21-30.
Crossref
Crossref
Michel Oettel & Ekkehard SchillingerW. Kuhnz, H. Blode & H. Zimmermann. 1999. Estrogens and Antiestrogens II. Estrogens and Antiestrogens II
261
322
.
V. Craig Jordan. (1992) The role of tamoxifen in the treatment and prevention of breast cancer. Current Problems in Cancer 16:3, pages 134-176.
Crossref
Crossref
Michael DeGregorio, Gregory Wurz, Vernon Emshoff, Steven Koester, Patrick Minor & Valerie Wiebe. (1992) A bioassay for antiestrogenic activity — potential utility in drug development and monitoring effectivein vivo dosing. Breast Cancer Research and Treatment 24:1, pages 35-41.
Crossref
Crossref
M. G�rlich, G. Winterfeld, P. Hauff, W. Arnold, I. Fichtner & H. -J. Staab. (1992) Investigations of droloxifene and other hormonal manipulations onN-nitrosomethylurea-induced rat mammary tumours. Journal of Cancer Research and Clinical Oncology 119:2, pages 97-100.
Crossref
Crossref
Edward J. Pavlik, Katherine Nelson, John R. van NagellJr.Jr., Holly S. Gallion, Elvis S. Donaldson, P. DePriest, Katherine Meares & John R. van NagellIIIIII. (1991) The growth response of BG-1 ovarian carcinoma cells to estradiol, 4OH-tamoxifen, and tamoxifen: Evidence for intrinsic antiestrogen activation. Gynecologic Oncology 42:3, pages 245-249.
Crossref
Crossref
Marvin J. TurnerIIIIII, Charles E. Fields & David B. Everman. (1991) Evidence for superoxide formation during hepatic metabolism of tamoxifen. Biochemical Pharmacology 41:11, pages 1701-1705.
Crossref
Crossref
Françoise Jacolot, Isabelle Simon, Yvonne Dreano, Philippe Beaune, Christian Riche & François Berthou. (1991) Identification of the cytochrome P450 IIIA family as the enzymes involved in the N-demethylation of tamoxifen in human liver microsomes. Biochemical Pharmacology 41:12, pages 1911-1919.
Crossref
Crossref
R.W. Koot, G.J. Amelink, M.A. Blankenstein & P.R. Bär. (1991) Tamoxifen and oestrogen both protect the rat muscle against physiological damage. The Journal of Steroid Biochemistry and Molecular Biology 40:4-6, pages 689-IN10.
Crossref
Crossref
Ginger A. Dickerson, I.Wade Waters, Marvin C. Wilson & W.Marvin Davis. (1991) Effect of sex steroids on cocaine lethality in male and female mice. General Pharmacology: The Vascular System 22:3, pages 553-557.
Crossref
Crossref
Hannu Sipilä, Lauri Kangas, Lauri Vuorilehto, Arm Kalapudas, Maire Eloranta, Marja Södervall, Reijo Toivola & Markku Anttila. (1990) Metabolism of toremifene in the rat. Journal of Steroid Biochemistry 36:3, pages 211-215.
Crossref
Crossref
V. Craig Jordan. (1990) Long-term adjuvant tamoxifen therapy for breast cancer: The prelude to prevention. Cancer Treatment Reviews 17:1, pages 15-36.
Crossref
Crossref
Karl-Heinz BeyerKarl-Heinz Beyer. 1990. Biotransformation der Arzneimittel. Biotransformation der Arzneimittel
517
518
.
Bruce W. Ennis & Walter E. Stumpf. (1988) Binding of estrogen and antiestrogen in uterine cell nuclei: In vivo autoradiographic studies. Journal of Steroid Biochemistry 31:4, pages 405-409.
Crossref
Crossref
J.R. Pasqualini, C. Sumida & N. Giambiagi. (1988) Pharmacodynamic and biological effects of anti-estrogens in different models. Journal of Steroid Biochemistry 31:4, pages 613-643.
Crossref
Crossref
Jean-François Miquel & Jacques Gilbert. (1988) A chemical classification of nonsteroidal antagonists of sex-steroid hormone action. Journal of Steroid Biochemistry 31:4, pages 525-544.
Crossref
Crossref
William S. Branham, David R. Zehr, James J. Chen & Daniel M. Sheehan. (2005) Alterations in developing rat uterine cell populations after neonatal exposure to estrogens and antiestrogens. Teratology 38:3, pages 271-279.
Crossref
Crossref
S. A. Matlin, Z. Y. Wu & Y. S. Kianchehr. (2005) Antihormonal agents part 3: Direct analysis of tamoxifen in serum by HPLC. Journal of High Resolution Chromatography 11:8, pages 602-605.
Crossref
Crossref
V. Craig Jordan. (1988) The development of tamoxifen for breast cancer therapy: A tribute to the late Arthur L. Walpole. Breast Cancer Research and Treatment 11:3, pages 197-209.
Crossref
Crossref
Jorge Raul Pasqualini & Chantal Gelly. (1988) Effect of tamoxifen and tamoxifen derivatives on the conversion of estrone sulfate to estradiol in the MCF-7 mammary cancer cell line. Cancer Letters 40:2, pages 115-121.
Crossref
Crossref
Shlomo Sasson & Angelo C. Notides. (1988) The effects of dimethylformamide on the interaction of the estrogen receptor with estradiol. Journal of Steroid Biochemistry 29:5, pages 491-495.
Crossref
Crossref
William S. Branham, Mary L. Leamons & Daniel M. Sheehan. (1988) Estrogen- and antiestrogen-induced ornithine decarboxylase activity and uterine growth in the rat. Journal of Steroid Biochemistry 29:2, pages 153-159.
Crossref
Crossref
S.P. Robinson & V.C. Jordan. (1988) Metabolism of steroid-modifying anticancer agents. Pharmacology & Therapeutics 36:1, pages 41-103.
Crossref
Crossref
C. Gelly & J.R. Pasqualini. (1988) Effect of tamoxifen and tamoxifen derivatives on the conversion of estrone-sulfate to estradiol in the R-27 cells, a tamoxifen-resistant line derived from MCF-7 human breast cancer cells. Journal of Steroid Biochemistry 30:1-6, pages 321-324.
Crossref
Crossref
K. Marshall & J. Senior. (2012) A study on the effect of a single dose of tamoxifen on uterine hyperaemia and growth in the rat. British Journal of Pharmacology 92:2, pages 429-435.
Crossref
Crossref
David M. Simpson, Jonathan F. Elliston & John A. Katzenellenbogen. (1987) Desmethylnafoxidine aziridine: An electrophilic affinity label for the estrogen receptor with high efficiency and selectivity. Journal of Steroid Biochemistry 28:3, pages 233-245.
Crossref
Crossref
Steven W.J. Lamberts & Theo Verleun. (1987) Differences in the mechanism of the inhibitory actions of catecholestrogens, tamoxifen and high concentrations of estrogens on prolactin release by cultured rat pituitary tumor cells. European Journal of Cancer and Clinical Oncology 23:8, pages 1117-1123.
Crossref
Crossref
Zbigniew FijaŁek, Jerzy Chodkowski & MaŁgorzata Warowna. (1987) Polarographic studies of drugs of triphenylethene derivatives. Journal of Electroanalytical Chemistry and Interfacial Electrochemistry 226:1-2, pages 129-136.
Crossref
Crossref
G. SCHIEFERSTEIN, W. ADAM, J. ARMANN, E. BANTEL, R. CÖRLIN, H. EGENRIEDER, G. FIERLBECK, B. HOOK, A. SCHIEK, G. SCHUBRING & R. SCHÜER. (2009) Ergebnisse der Tamoxifen-Therapie bei Oligozoospermie Teil II: Hormonanalysen und Ejakulatbefunde. Andrologia 19:3, pages 333-341.
Crossref
Crossref
C. Murphy, T. Fotsis, P. Pantzar, H. Adlercreut & F. Martin. (1987) Analysis of tamoxifen and its metabolites in human plasma by gas chromatography-mass spectrometry (GC-MS) using selected ion monitoring (SIM). Journal of Steroid Biochemistry 26:5, pages 547-555.
Crossref
Crossref
Iris B. Parr, Raymond McCague, Guy Leclercq & Susanna Stoessel. (1987) Metabolism of tamoxifen by isolated rat hepatocytes. Biochemical Pharmacology 36:9, pages 1513-1519.
Crossref
Crossref
M. Nieder & H. Jaeger. (1987) Quantification of tamoxifen and n-desmethyltamoxifen in human plasma by high-performance liquid chromatography, photochemical reaction and fluorescence detection, and its application to biopharmaceutic investigations. Journal of Chromatography B: Biomedical Sciences and Applications 413, pages 207-217.
Crossref
Crossref
J.R. Pasqualini, B.-L. Nguyen, C. Sumida, N. Giambiagi & C. Mayrand. (1986) Tamoxifen and progesterone effects in target tissues during the perinatal period. Journal of Steroid Biochemistry 25:5, pages 853-857.
Crossref
Crossref
Anna Tate riegel, V.Craig Jordan, Richard R. Bain & Daniel R. Schoenberg. (1986) Effects of antiestrogens on the induction of vitellogenin and its mRNA in Xenopus laevis. Journal of Steroid Biochemistry 24:6, pages 1141-1149.
Crossref
Crossref
Raymond McCague & Alison Seago. (1986) Aspects of metabolism of tamoxifen by rat liver microsomes. Biochemical Pharmacology 35:5, pages 827-834.
Crossref
Crossref
D.H. Hunter & L.A. Strickland. (1986) An 131I iodotamoxifen: No carrier added iodination via a diazonium salt. International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes 37:8, pages 889-891.
Crossref
Crossref
J.R. Pasqualini, N. Giambiagi, C. Sumida, B.-L. Nguyen, C. Gelly, C. Mayrand & F. Lecerf. (1986) Biological responses of tamoxifen in the fetal and newborn vagina and uterus of the guinea-pig and in the R-27 mammary cancer cell line. Journal of Steroid Biochemistry 24:1, pages 99-108.
Crossref
Crossref
Grant E. Schmidt, Cindy Sites, Ragaa Mansour, Chad I. Friedman & Moon H. Kim. (1985) Embryo toxicity of clomiphene citrate on mouse embryos fertilized in vitro and in vivo. American Journal of Obstetrics and Gynecology 153:6, pages 679-684.
Crossref
Crossref
Stewart D. Lyman & V. Craig Jordan. (1985) Metabolism of tamoxifen and its uterotrophic activity. Biochemical Pharmacology 34:15, pages 2787-2794.
Crossref
Crossref
John A. Katzenellenbogen, Kathryn E. Carlson & Benita S. Katzenellenbogen. (1985) Facile geometric isomerization of phenolic non-steroidal estrogens and antiestrogens: Limitations to the interpretation of experiments characterizing the activity of individual isomers. Journal of Steroid Biochemistry 22:5, pages 589-596.
Crossref
Crossref
C. Paul Daniel, Simon J. Gaskell & Robert I. Nicholson. (1984) The measurement of tamoxifen and metabolites in the rat and relationship to the response of DMBA-induced mammary tumours. European Journal of Cancer and Clinical Oncology 20:1, pages 137-143.
Crossref
Crossref
B.J.A. Furr & V.C. Jordan. (1984) The pharmacology and clinical uses of tamoxifen. Pharmacology & Therapeutics 25:2, pages 127-205.
Crossref
Crossref
Noel M. Meltzer, Patrick Stang, Larry A. Sternson & Adelbert E. Wade. (1984) Influence of tamoxifen and its N-desmethyl and 4-hydroxy metabolites on rat liver microsomal enzymes. Biochemical Pharmacology 33:1, pages 115-123.
Crossref
Crossref
M. Jarman, A. B. Foster, M. H. Baker, P. E. Goss, C.-S. Leung, O.-T. Leung, R. McCague, M. G. Rowlands, R. C. Coombes & G. Leclerq. 1984. Cancer Chemotherapy and Selective Drug Development. Cancer Chemotherapy and Selective Drug Development
485
489
.
H. K. Adam. 1985. Drug Determination in Therapeutic and Forensic Contexts. Drug Determination in Therapeutic and Forensic Contexts
211
217
.
Andrew P. Waters, Alan E. Wakeling & John T. Knowler. (1983) Tamoxifen-induced changes in the polyribosomes and associated mRNA of rat uterus. Molecular and Cellular Endocrinology 32:2-3, pages 233-244.
Crossref
Crossref
Peter C. Ruenitz, Jerome R. Bagley & Corwin M. Mokler. (1983) Metabolism of clomiphene in the rat. Biochemical Pharmacology 32:19, pages 2941-2947.
Crossref
Crossref
V.C. Jordan & B. Gosden. (1983) Differential antiestrogen action in the immature rat uterus: A comparison of hydroxylated antiestrogens with high affinity for the estrogen receptor. Journal of Steroid Biochemistry 19:3, pages 1249-1258.
Crossref
Crossref
Anna C. Tate, Eugene R. DeSombre, Geoffrey L. Greene, Elwood V. Jensen & V. Craig Jordan. (1983) Interaction of [3H] estradiol — and [3H] monohydroxytamoxifen-estrogen receptor complexes with a monoclonal antibody. Breast Cancer Research and Treatment 3:3, pages 267-277.
Crossref
Crossref
Benita S. Katzenellenbogen, Margaret A. Miller, Richard L. Eckert & Katsuichi Sudo. (1983) Antiestrogen pharmacology and mechanism of action. Journal of Steroid Biochemistry 19:1, pages 59-68.
Crossref
Crossref
John V. Kemp, Hugh K. Adam, Alan E. Wakeling & Roger Slater. (1983) Identification and biological activity of tamoxifen metabolites in human serum. Biochemical Pharmacology 32:13, pages 2045-2052.
Crossref
Crossref
M E Lieberman, V C Jordan, M Fritsch, M A Santos & J Gorski. (1983) Direct and reversible inhibition of estradiol-stimulated prolactin synthesis by antiestrogens in vitro.. Journal of Biological Chemistry 258:8, pages 4734-4740.
Crossref
Crossref
V. Craig Jordan & C. Chem. (1983) Laboratory studies to develop general principles for the adjuvant treatment of breast cancer with antiestrogens: Problems and potential for future clinical applications. Breast Cancer Research and Treatment 3:S1, pages S73-S86.
Crossref
Crossref
Raymond R. Brown, Richard Bain & V.Craig Jordan. (1983) Determination of tamoxifen and metabolites in human serum by high-performance liquid chromatography with post-column fluorescence activation. Journal of Chromatography B: Biomedical Sciences and Applications 272, pages 351-358.
Crossref
Crossref
BENITA S. KATZENELLENBOGEN, MARGARET A. MILLER, RICHARD L. ECKERT & KATSUICHI SUDO. 1983. Hormonal Steroids. Hormonal Steroids
59
68
.
Shubhra Garg, R.D. Bindal, S. Durani & R.S. Kapil. (1983) Structure-activity relationship of estrogens: A study involving cyclofenyl as the model compound. Journal of Steroid Biochemistry 18:1, pages 89-95.
Crossref
Crossref
D.J. Bates, A.B. Foster, L.J. Griggs, M. Jarman, G. Leclerco & N. Devleeschouwer. (1982) Metabolism of tamoxifen by isolated rat hepatocytes: anti-estrogenic activity of tamoxifen N-oxide. Biochemical Pharmacology 31:17, pages 2823-2827.
Crossref
Crossref
V. Craig Jordan & C. Chem.. (1982) Metabolites of tamoxifen in animals and man: Identification, pharmacology, and significance. Breast Cancer Research and Treatment 2:2, pages 123-138.
Crossref
Crossref
N. Wilking, L.‐E. Appelgren, K. Carlström, Å. Pousette & N. O. Theve. (2009)
The Distribution and Metabolism of
14
C‐Labelled Tamoxifen in Spayed Female Mice
. Acta Pharmacologica et Toxicologica 50:3, pages 161-168.
Crossref
Crossref
J Burns & D Rutter(The Late)(The Late). (2006) The preparation of carbon‐14 and tritium labelled 1‐[4‐(2‐dimethylaminoethoxy)phenyl]‐1, 2‐diphenyl‐1‐butene [ICI 46,474, tamoxifen (‘nolvadex’)] and the separation of cis‐trans isomers I. The synthesis of carbon‐14 labelled tamoxifen (‘nolvadex’). Journal of Labelled Compounds and Radiopharmaceuticals 19:2, pages 229-238.
Crossref
Crossref
Robert L. Sutherland & Leigh C. Murphy. (1982) Mechanisms of oestrogen antagonism by nonsteroidal antioestrogens. Molecular and Cellular Endocrinology 25:1, pages 5-23.
Crossref
Crossref
Robert N. Hanson & David E. Seitz. (1982) Tissue distribution of the radiolabeled antiestrogen [125I]iodotamoxifen. International Journal of Nuclear Medicine and Biology 9:2, pages 105-107.
Crossref
Crossref
M.A. Vass & B. Green. (1982) Effects of hydroxytamoxifen and tamoxifen on peroxidase activity in the immature rat uterus. Journal of Steroid Biochemistry 16:1, pages 125-127.
Crossref
Crossref
David W. Robertson, John A. Katzenellenbogen, Deborah J. Long, Ellen A. Rorke & Benita S. Katzenellenbogen. (1982) Tamoxifen antiestrogens. A comparison of the activity, pharmacokinetics, and metabolic activation of the cis and trans isomers of tamoxifen. Journal of Steroid Biochemistry 16:1, pages 1-13.
Crossref
Crossref
V. Craig Jordan. 1982. Hormones and Cancer. Hormones and Cancer
165
178
.
Benita S. Katzenellenbogen, Ellen A. Rorke & Richard L. Eckert. (1981) Mechanisms of estrogen and antiestrogen action in mammary cancer. Journal of Steroid Biochemistry 15, pages 219-229.
Crossref
Crossref
Heinz Lüllmann & Renate Lüllmann-Rauch. (1981) Tamoxifen-induced generalized lipidosis in rats subchronically treated with high doses. Toxicology and Applied Pharmacology 61:1, pages 138-146.
Crossref
Crossref
Peter J. Harman, Graeme L. Blackman & George Phillipou. (1981) High-performance liquid chromatographic determination of clomiphene using post-column on-line photolysis and fluorescence detection. Journal of Chromatography B: Biomedical Sciences and Applications 225:1, pages 131-138.
Crossref
Crossref
Mels Sluyser, Siegina G. Evers & Cornelis C.J. De Goeij. (1981) Effect of monohydroxytamoxifen on mouse mammary tumors. European Journal of Cancer and Clinical Oncology 17:9, pages 1063-1065.
Crossref
Crossref
Glenn L. Tonnesen, Robert N. Hanson & David E. Seitz. (1981) Position-specific radioiodination utilizing an aryltributylstannyl intermediate. Synthesis of 125I-iodotamoxifen. The International Journal of Applied Radiation and Isotopes 32:3, pages 171-173.
Crossref
Crossref
A. E. Wakeling & S. R. Slater. 1981. Mechanisms of Steroid Action. Mechanisms of Steroid Action
159
171
.
Jean-Louis Borgna & Henri Rochefort. (1980) High-affinity binding to the estrogen receptor of [3H]4-hydroxytamoxifen, an active antiestrogen metabolite. Molecular and Cellular Endocrinology 20:1, pages 71-85.
Crossref
Crossref
A.B. Foster, L.J. Griggs, M. Jarman, J.M.S. Van Maanen & H.-R. Schulten. (1980) Metabolism of tamoxifen by rat liver microsomes: formation of the N-oxide, a new metabolite. Biochemical Pharmacology 29:13, pages 1977-1979.
Crossref
Crossref
Peter C. Ruenitz & Mo M. Toledo. (1980) Inhibition of rabbit liver microsomal oxidative metabolism and substrate binding by tamoxifen and the geometric isomers of clomiphene. Biochemical Pharmacology 29:11, pages 1583-1587.
Crossref
Crossref
V.C. Jordan & Karen E. Allen (née Naylor). (1980) Evaluation of the antitumour activity of the non-steroidal antioestrogen monohydroxytamoxifen in the DMBA-induced rat mammary carcinoma model. European Journal of Cancer (1965) 16:2, pages 239-251.
Crossref
Crossref
KAREN E. ALLEN, E.R. CLARK & V.C. JORDAN. (2015) EVIDENCE FOR THE METABOLIC ACTIVATION OF NON‐STEROIDAL ANTIOESTROGENS: A STUDY OF STRUCTURE‐ACTIVITY RELATIONSHIPS. British Journal of Pharmacology 71:1, pages 83-91.
Crossref
Crossref
Yechiel Golander & Larry A. Sternson. (1980) Paired-ion chromatographic analysis of tamoxifen and two major metabolites in plasma. Journal of Chromatography B: Biomedical Sciences and Applications 181:1, pages 41-49.
Crossref
Crossref
V. C. Jordan, K. E. Naylor, C. J. Dix & G. Prestwich. 1980. Endocrine Treatment of Breast Cancer. Endocrine Treatment of Breast Cancer
30
44
.
Dean P. Edwards, Gary C. Chamness & William L. McGuire. (1979) Estrogen and progesterone receptor proteins in breast cancer. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 560:4, pages 457-486.
Crossref
Crossref
G. Leclercq & J.C. Heuson. (1979) Physiological and pharmacological effects of estrogens in breast cancer. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 560:4, pages 427-455.
Crossref
Crossref
N. Binart, M.G. Catelli, C. Geynet, V. Puri, R. Hähnel, J. Mes̆ter & E.E. Baulieu. (1979) Monohydroxytamoxifen: An antioestrogen with high affinity for the chick oviduct oestrogen receptor. Biochemical and Biophysical Research Communications 91:3, pages 812-818.
Crossref
Crossref
Angela M.H. Brodie, David A. Marsh, J.T. Wu & Harry J. Brodie. (1979) Aromatase inhibitors and their use in controlling oestrogen-dependent processes. Journal of Steroid Biochemistry 11:1, pages 107-112.
Crossref
Crossref
R.I. Nicholson, J.S. Syne, C.P. Daniel & K. Griffiths. (1979) The binding of tamoxifen to oestrogen receptor proteins under equilibrium and non-equilibrium conditions. European Journal of Cancer (1965) 15:3, pages 317-329.
Crossref
Crossref
V.C. JORDAN & KAREN E. NAYLOR. (1979)
THE BINDING OF [
3
H]-OESTRADIOL-17β IN THE IMMATURE RAT UTERUS DURING THE SEQUENTIAL ADMINISTRATION OF NONSTEROIDAL ANTI-OESTROGENS
. British Journal of Pharmacology 65:2, pages 167-173.
Crossref
Crossref
ANGELA M.H. BRODIE, DAVID A. MARSH, J.T. WU & HARRY J. BRODIE. 1979. Hormonal Steroids. Hormonal Steroids
107
112
.
H.M. Bolt. (1979) Metabolism of estrogens—natural and synthetic. Pharmacology & Therapeutics 4:1, pages 155-181.
Crossref
Crossref
H.K. Adam, E.J. Douglas & J.V. Kemp. (1979) The metabolism of tamoxifen in humans. Biochemical Pharmacology 28:1, pages 145-147.
Crossref
Crossref
Françoise Capony & Henri Rochefort. (1978) High-affinity binding of the antiestrogen [3H]tamoxifen to the 8S estradiol receptor. Molecular and Cellular Endocrinology 11:2, pages 181-198.
Crossref
Crossref
Henry J. Tagnon. (1977) Antiestrogens in treatment of breast cancer. Cancer 39:6, pages 2959-2964.
Crossref
Crossref
V.C. Jordan, C.J. Dix, Linda Rowsby & G. Prestwich. (1977) Studies on the mechanism of action of the nonsteroidal antioestrogen tamoxifen (I.C.I. 46,474) in the rat. Molecular and Cellular Endocrinology 7:2, pages 177-192.
Crossref
Crossref
R.I. Nicholson, P. Davies & K. Griffiths. (1977) Effects of oestradiol-17β and tamoxifen on nuclear oestradiol-17β receptors in DMBA-induced rat mammary tumours. European Journal of Cancer (1965) 13:3, pages 201-208.
Crossref
Crossref
J. M. Fromson & D. S. Sharp. (2005) THE SELECTIVE UPTAKE OF TAMOXIFEN BY HUMAN UTERINE TISSUE. BJOG: An International Journal of Obstetrics & Gynaecology 81:4, pages 321-323.
Crossref
Crossref