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Xenobiotica
the fate of foreign compounds in biological systems
Volume 3, 1973 - Issue 11
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Research Article

The Metabolism of Tamoxifen (I.C.I. 46,474) Part II: In Female Patients

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Pages 711-714 | Received 02 Apr 1973, Published online: 14 Oct 2008

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Ondřej Slanař, Karolína Hronová, Olga Bartošová & Martin Šíma. (2021) Recent advances in the personalized treatment of estrogen receptor-positive breast cancer with tamoxifen: a focus on pharmacogenomics. Expert Opinion on Drug Metabolism & Toxicology 17:3, pages 307-321.
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Sarah J. Roffey, R. Scott Obach, Jenny I. Gedge & Dennis A. Smith. (2007) What is the Objective of the Mass Balance Study? A Retrospective Analysis of Data in Animal and Human Excretion Studies Employing Radiolabeled Drugs. Drug Metabolism Reviews 39:1, pages 17-43.
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V. Craig Jordan. (2006) Activated Estrogens and Antiestrogens: A 30-Year Journey with David Kupfer. Drug Metabolism Reviews 38:1-2, pages 117-127.
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Lewis L. Smith, Karen Brown, Philip Carthew, Chang-Kee Lim, Elizabeth A. Martin, Jerry Styles & Ian N. H. White. (2000) Chemoprevention of Breast Cancer by Tamoxifen: Risks and Opportunities. Critical Reviews in Toxicology 30:5, pages 571-594.
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BruceJ. Wilbur, ChristopherC. Benz & MichaelW. Degregorio. (1985) Quantitation of Tamoxifen, 4-Hydroxytamoxifen, and N-Desmethyltamoxifen in Human Plasma by High Performance Liquid Chromatography. Analytical Letters 18:15, pages 1915-1924.
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V. Craig Jordan, CliveJ. Dix, KarenE. Naylor, Graham Prestwich & Linda Rowsby. (1978) Nonsteroidal antiestrogens: Their biological effects and potential mechanisms of action. Journal of Toxicology and Environmental Health 4:2-3, pages 363-390.
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Articles from other publishers (95)

Comfort Ropafadzo Kanji, Georginah Nyabadza, Charles Nhachi & Collen Masimirembwa. (2023) Pharmacokinetics of Tamoxifen and Its Major Metabolites and the Effect of the African Ancestry Specific CYP2D6*17 Variant on the Formation of the Active Metabolite, Endoxifen. Journal of Personalized Medicine 13:2, pages 272.
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Jasna Markovac & Robert Marcus. 2020. Principles of Bone Biology. Principles of Bone Biology 863 893 .
Balkees Abderrahman & V. Craig Jordan. 2019. Estrogen Receptor and Breast Cancer. Estrogen Receptor and Breast Cancer 151 188 .
Raie T. Bekele, Ganesh Venkatraman, Rong-Zong Liu, Xiaoyun Tang, Si Mi, Matthew G. K. Benesch, John R. Mackey, Roseline Godbout, Jonathan M. Curtis, Todd P. W. McMullen & David N. Brindley. (2016) Oxidative stress contributes to the tamoxifen-induced killing of breast cancer cells: implications for tamoxifen therapy and resistance. Scientific Reports 6:1.
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E. A. Nada, M. A. El Taieb, H. M. Ibrahim & A. E.-R. A. Al Saied. (2015) Efficacy of tamoxifen and l -carnitine on sperm ultrastructure and seminal oxidative stress in patients with idiopathic oligoasthenoteratozoospermia . Andrologia 47:7, pages 801-810.
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V. C. Jordan. (2014) Tamoxifen as the first targeted long-term adjuvant therapy for breast cancer. Endocrine Related Cancer 21:3, pages R235-R246.
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Jian Meng. 2014. Handbook of Metabolic Pathways of Xenobiotics. Handbook of Metabolic Pathways of Xenobiotics 1 4 .
Jian Meng. 2014. Handbook of Metabolic Pathways of Xenobiotics. Handbook of Metabolic Pathways of Xenobiotics 1 3 .
Peter L Jacobs, Lars Ridder, Marco Ruijken, Hilde Rosing, Nynke GL Jager, Jos H Beijnen, Richard R Bas & William D van Dongen. (2013) Identification of drug metabolites in human plasma or serum integrating metabolite prediction, LC–HRMS and untargeted data processing. Bioanalysis 5:17, pages 2115-2128.
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Philipp Y. Maximov, Russell E. McDaniel & V. Craig JordanPhilipp Y. Maximov, Russell E. McDaniel & V. Craig Jordan. 2013. Tamoxifen. Tamoxifen 47 67 .
Philipp Y. Maximov, Russell E. McDaniel & V. Craig JordanPhilipp Y. Maximov, Russell E. McDaniel & V. Craig Jordan. 2013. Tamoxifen. Tamoxifen 31 46 .
Alexander V. LyubimovDeepak K. Dalvie & Cho‐Ming Loi. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 36 .
Alexander V. LyubimovDeepak K. Dalvie. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 54 .
C. Gómez, O.J. Pozo, R. Diaz, J.V. Sancho, E. Vilaroca, J.P. Salvador, M.P. Marco, F. Hernandez, J. Segura & R. Ventura. (2011) Mass spectrometric characterization of urinary toremifene metabolites for doping control analyses. Journal of Chromatography A 1218:29, pages 4727-4737.
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Denise Poisson, Antoine Dupuis, Michel Breteau, Serge Bouquet, Marc Poterre & William Couet. (1997) Effect of Tamoxifen on the Pharmacokinetics of Theophylline in Rats. Journal of Pharmacy and Pharmacology 49:1, pages 40-42.
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S.F. Teunissen, H. Rosing, A.H. Schinkel, J.H.M. Schellens & J.H. Beijnen. (2010) Bioanalytical methods for determination of tamoxifen and its phase I metabolites: A review. Analytica Chimica Acta 683:1, pages 21-37.
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Jinsong Ni, Hui Ouyang, Carmai Seto, Takeo Sakuma, Robert Ellis, Josh Rowe, Andrew Acheampong, Devin Welty & Gabriella Szekely-Klepser. (2010) Sensitivity and proportionality assessment of metabolites from microdose to high dose in rats using LC–MS/MS. Bioanalysis 2:3, pages 407-419.
Crossref
Henry U. Bryant. 2008. Principles of Bone Biology. Principles of Bone Biology 887 919 .
Cora J Fong, Lyle D Burgoon, Kurt J Williams, Agnes L Forgacs & Timothy R Zacharewski. (2007) Comparative temporal and dose-dependent morphological and transcriptional uterine effects elicited by tamoxifen and ethynylestradiol in immature, ovariectomized mice. BMC Genomics 8:1.
Crossref
Y.F. LI, S. FU, W. HU, J.H. LIU, K.W. FINKEL, D.M. GERSHENSON & J.J. KAVANAGH. (2007) Systemic anticancer therapy in gynecological cancer patients with renal dysfunction. International Journal of Gynecological Cancer 17:4, pages 739-763.
Crossref
Charles M. Buchanan, Norma L. Buchanan, Kevin J. Edgar, James L. Little, Michael O. Malcolm, Karen M. Ruble, Vincent J. Wacher & Michael F. Wempe. (2007) Pharmacokinetics of Tamoxifen after Intravenous and Oral Dosing of Tamoxifen–Hydroxybutenyl-β-Cyclodextrin Formulations. Journal of Pharmaceutical Sciences 96:3, pages 644-660.
Crossref
V.C. Jordan. 2007. Comprehensive Medicinal Chemistry II. Comprehensive Medicinal Chemistry II 83 102 .
Paula I. Moreira, José Custódio, António Moreno, Catarina R. Oliveira & Maria S. Santos. (2006) Tamoxifen and Estradiol Interact with the Flavin Mononucleotide Site of Complex I Leading to Mitochondrial Failure. Journal of Biological Chemistry 281:15, pages 10143-10152.
Crossref
Kenichiro Ogura, Yuko Ishikawa, Teppei Kaku, Takahito Nishiyama, Tomokazu Ohnuma, Kei Muro & Akira Hiratsuka. (2006) Quaternary ammonium-linked glucuronidation of trans-4-hydroxytamoxifen, an active metabolite of tamoxifen, by human liver microsomes and UDP-glucuronosyltransferase 1A4. Biochemical Pharmacology 71:9, pages 1358-1369.
Crossref
Hidetoshi Yamaya, Mayuko Saeki, Ken-ichiro Yoshida, Jiro Shibata, Shingo Yano, Yoshiaki Sato, Atsushi Takao, Takashi Shindo, Aman U. Buzdar & Sekio Nagayama. (2006) DISTRIBUTION OF (7α)-21-[4-[(DIETHYLAMINO) METHYL]-2-METHOXYPHENOXY]-7-METHYL-19-NORPREGNA-1,3,5(10)-TRIEN-3-OL-20-[ 14 C]2-HYDROXY-1,2,3-PROPANETRICARBOXYLATE ([ 14 C]TAS-108) AND ITS METABOLITES AFTER SINGLE ORAL ADMINISTRATION TO RATS BEARING 7,12-DIMETHYLBENZ(α)ANTHRACENE-INDUCED MAMMARY TUMOR . Drug Metabolism and Disposition 34:2, pages 331-338.
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Teppei Kaku, Kenichiro Ogura, Takahito Nishiyama, Tomokazu Ohnuma, Kei Muro & Akira Hiratsuka. (2004) Quaternary ammonium-linked glucuronidation of tamoxifen by human liver microsomes and UDP-glucuronosyltransferase 1A4. Biochemical Pharmacology 67:11, pages 2093-2102.
Crossref
He Changhai, Gui Youlun, Yang Jie, Wang Bingshun, Zheng Exiang, Gao Ersheng & Christine Mauck. (2002) A randomized comparative study on mifepristone alone and in combination with tamoxifen for emergency contraception. Contraception 66:4, pages 221-224.
Crossref
Michael Harper. 2002. The Endometrium. The Endometrium 705 719 .
Xing-Fang Li, Spencer Carter, Norman J. Dovichi, Jane Y. Zhao, Peter Kovarik & Takeo Sakuma. (2001) Analysis of tamoxifen and its metabolites in synthetic gastric fluid digests and urine samples using high-performance liquid chromatography with electrospray mass spectrometry. Journal of Chromatography A 914:1-2, pages 5-12.
Crossref
J. Z. Guo, D. W. Hahn & M. P. Wachter. 2001. Kirk-Othmer Encyclopedia of Chemical Technology. Kirk-Othmer Encyclopedia of Chemical Technology.
E.A. Lien & P.E. Lønning. (2000) Selective oestrogen receptor modifiers (SERMs) and breast cancer therapy. Cancer Treatment Reviews 26:3, pages 205-227.
Crossref
Nuhad K Ibrahim & Gabriel N Hortobagyi. (1999) The evolving role of specific estrogen receptor modulators (SERMs). Surgical Oncology 8:2, pages 103-123.
Crossref
Shin‐ichi Ishioka, Satoru Sagae, Kanji Kobayashi, Masaki Sugimura, Yoshihiro Nishioka & Ryuichi Kudo. (2010) A Case of Simultaneous Presence of Primary Endometrial Carcinoma and Metastasis of a Breast Carcinoma to the Ovary after 5 Years of Tamoxifen Therapy. Journal of Obstetrics and Gynaecology Research 25:2, pages 113-117.
Crossref
C. Geraldine M. Jordan, K. Brown, C. Beedham & J.E. Brown. (1999) EFFECT OF INHIBITORS ON THE BIOTRANSFORMATION OF TAMOXIFEN BY FEMALE RAT AND MOUSE LIVER SLICES AND HOMOGENATES. Drug Metabolism and Drug Interactions 15:4.
Crossref
David J. Boocock, James L. Maggs, Ian N.H. White & B. Kevin Park. (1999) α-Hydroxytamoxifen, a genotoxic metabolite of tamoxifen in the rat: identification and quantification in vivo and in vitro. Carcinogenesis 20:1, pages 153-160.
Crossref
H.K Lim, S Stellingweif, S Sisenwine & K.W Chan. (1999) Rapid drug metabolite profiling using fast liquid chromatography, automated multiple-stage mass spectrometry and receptor-binding. Journal of Chromatography A 831:2, pages 227-241.
Crossref
Suprabhat Ray & Indra Dwivedy. 1997. 171 270 .
Ian N. H. White & Lewis L. Smith. 1996. Hormonal Carcinogenesis II. Hormonal Carcinogenesis II 228 239 .
Per E. Lønning & Ernst A. Lien. (1995) Mechanisms of action of endocrine treatment in breast cancer. Critical Reviews in Oncology/Hematology 21:1-3, pages 158-193.
Crossref
Margitta Albinus, Gudrun Amschler, Uwe Amschler, Erwin von Angerer, Wolfgang Barthel, Andrea Bauer, Kurt Bauer, Jürgen Beckmann, Winfried Beil, Jürgen Beitz, Petra Berscht, Thorsten Beyrich, Katja Binder, Roswitha Böhme, Hans-Hubertus Borchert, Franz Bracher, Helmut Bräunlich, Kerstin Brinkmann, Franz von Bruchhausen, Kay Brune, Axel Büge, Wolfram Christ, Monika Cimbollek, Rolf Daniels, Gerd Dannhardt, Hans-Jürgen Duchstein, Siegfried Ebel, Kurt Eger, Peter Emig, Thomas Erker, Maria S. Fernandez-Alfonso, August Wilhelm Frahm, Margarete Frahm, Klaus-Jürgen Freundt, Detlef Geffken, Ulrich Geis, Erika Glusa, Berthold Göber, Jochen Gödicke, Margarete Goppelt-Strübe, Wilhelm Gössling, Annette Graul, Sibylle Greiner, Adolf Grisk, Michael Grosam, Markus von Gruchalla, Michael Gütschow, Axel Haberkorn, Eberhard Hackenthal, Annette Häfner, Boris Haluszczynski, Achim Harder, Sabine Hartmann, Susanne Hartmann, Dieter Heber, Gerhard Heinemeyer, Andreas Hensel, Sibylle Hoedt-Schmidt, Hermann Hoffmann, Ute Hoffmann-Schollmayer, Ulrike Holzgrabe, Martin Hug, Wolfgang Ibrom, Elisabeth Inkmann, Jens Jürgens, Brigitte Kaiser, Dieter-Abbo Kalbhen, Nasser Khudeir, Werner Kiefer, Doris Kleinsorge, Christoph Klett, Stephanie Klett, Martin Klingmüller, H.-P. Klöcking, Gerd Kobal, Axel Kramer, Mareta Kreher, Gottfried Kreutz, Reinhard Kroker, Dorothea Landsiedel-Maier, Jochen Lehmann, Marion Sylvia Lehner, Stefan Leiner, Hans Löwe, Johannes Mann, Detlef Manns, Wolfgang Matthiessen, Andreas Maurer, Wolfgang Meindl, Klaus Menges, Paul Messinger, Hans-Jürgen Mest, Frank Peter Meyer, J. Mollière, Rudolf Morgenstern, Wolfgang Morick, Joachim Mössner, Christa Müller, Daniel Müller, Klaus Müller, Walter Müller, Alexander Mülsch, Tilo Netzer, Michael Neugebauer, Ulf Niemeyer, Peter Nuhn, Bernd Nürnberg, Joachim Oertel, Michael Oettel, Hartmut Oßwald, Robert Ott, Tilmann Ott, Thomas Otzen, Peter Pachaly, Helmut Pelzer, Karl-Uwe Petersen, Martina Pickert, Andreas Pies, Klaus Pietrzik, Detlef Preiss, Helmut Priewer, Olaf Queckenberg, Eberhard Reimann, Jörg Remien, Rainer Rettig, Andreas Reymann, Joachim Richter, Hans Rommelspacher, Ulrich Rose, Gerhard Rücker, Klaus Schaefer, Helmut Schlager, Werner Schleicher, Hildegard Schleinitz, Wolfgang Schlichter, Helmut Schmidhammer, Gerhard Schmidt, Timo Schmidt, Johannes Schräder, Thomas Schulz, Gert Schulze, Peter Schwanz, Helmut Schwilden, Monika Serke, Gisela Skopp, Marcus Spohn, Ralf Stahlmann, Johannes-Peter Stasch, Christian Steffen, Jürgen Steinmeyer, Karl-Heinz Surborg, Ulf Sürig, Istvan Szelenyi, Reinhard Troschütz, Michael Verborg, Eugen J. Verspohl, Franz-Josef Volk, Heinz Walther, Horst Weber, Judith Wede, Martin Wenzel, Marion Weyandt-Spangenberg, Sandra Wich, Hilke Winterhoff, Reinhold Wintersteiger, Frauke Woltmann, Diaa Youssef & A. Ziegler. 1994. Hagers Handbuch der Pharmazeutischen Praxis. Hagers Handbuch der Pharmazeutischen Praxis 765 1129 .
Surinder K. Chander, Surinder S. Sahota, Thomas R.J. Evans & Yunus A. Luqmani. (1993) The biological evaluation of novel antioestrogens for the treatment of breast cancer. Critical Reviews in Oncology/Hematology 15:3, pages 243-269.
Crossref
Michel Oettel & Ekkehard SchillingerW. Kuhnz, H. Blode & H. Zimmermann. 1999. Estrogens and Antiestrogens II. Estrogens and Antiestrogens II 261 322 .
S.J. Gatley, E.R. Desombre, R.C. Mease, R.E. Seevers, A. Hughes, J. Li & M.-L. Pan. (1991) Synthesis, purification and stability of no carrier added radioiodinated 1,1-bis(4-hydroxyphenyl)-2-iodo-2-phenylethylene (IBHPE), a prototype triphenylethylene estrogen-receptor binding radiopharmaceutical. International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology 18:7, pages 769-775.
Crossref
Günter SeyffartGünter Seyffart. 1991. Drug Dosage in Renal Insufficiency. Drug Dosage in Renal Insufficiency 558 603 .
. (2001) Mechanism of inhibition of lipid peroxidation by tamoxifen and 4‐hydroxytamoxifen introduced into liposomes. FEBS Letters 274:1-2, pages 107-110.
Crossref
Raymond McCague, Iris B. Parr, Guy Leclercq, On-Tai Leung & Michael Jarman. (1990) Metabolism of tamoxifen by isolated rat hepatocytes. Biochemical Pharmacology 39:9, pages 1459-1465.
Crossref
Helen Wiseman, Miranda J. Laughton, Henry R.V. Arnstein, Michael Cannon & Barry Halliwell. (1990) The antioxidant action of tamoxifen and its metabolites Inhibition of lipid peroxidation. FEBS Letters 263:2, pages 192-194.
Crossref
J.R. Pasqualini, C. Sumida & N. Giambiagi. (1988) Pharmacodynamic and biological effects of anti-estrogens in different models. Journal of Steroid Biochemistry 31:4, pages 613-643.
Crossref
Jean-François Miquel & Jacques Gilbert. (1988) A chemical classification of nonsteroidal antagonists of sex-steroid hormone action. Journal of Steroid Biochemistry 31:4, pages 525-544.
Crossref
S.P. Robinson & V.C. Jordan. (1988) Metabolism of steroid-modifying anticancer agents. Pharmacology & Therapeutics 36:1, pages 41-103.
Crossref
Zbigniew FijaŁek, Jerzy Chodkowski & MaŁgorzata Warowna. (1987) Polarographic studies of drugs of triphenylethene derivatives. Journal of Electroanalytical Chemistry and Interfacial Electrochemistry 226:1-2, pages 129-136.
Crossref
C. Murphy, T. Fotsis, P. Pantzar, H. Adlercreut & F. Martin. (1987) Analysis of tamoxifen and its metabolites in human plasma by gas chromatography-mass spectrometry (GC-MS) using selected ion monitoring (SIM). Journal of Steroid Biochemistry 26:5, pages 547-555.
Crossref
Iris B. Parr, Raymond McCague, Guy Leclercq & Susanna Stoessel. (1987) Metabolism of tamoxifen by isolated rat hepatocytes. Biochemical Pharmacology 36:9, pages 1513-1519.
Crossref
J.R. Pasqualini, C. Sumida, N.A. Giambiagi & B.-L. Nguyen. (1987) The complexity of anti-estrogen responses. Journal of Steroid Biochemistry 27:4-6, pages 883-889.
Crossref
J.R. Pasqualini, B.-L. Nguyen, C. Sumida, N. Giambiagi & C. Mayrand. (1986) Tamoxifen and progesterone effects in target tissues during the perinatal period. Journal of Steroid Biochemistry 25:5, pages 853-857.
Crossref
Kari Soininen, Terttu Kleimola, Inkeri Elomaa, Matti Salmo & Pentti Rissanen. (2016) The Steady-State Pharmacokinetics of Tamoxifen and its Metabolites in Breast Cancer Patients. Journal of International Medical Research 14:3, pages 162-165.
Crossref
Raymond McCague & Alison Seago. (1986) Aspects of metabolism of tamoxifen by rat liver microsomes. Biochemical Pharmacology 35:5, pages 827-834.
Crossref
D.H. Hunter & L.A. Strickland. (1986) An 131I iodotamoxifen: No carrier added iodination via a diazonium salt. International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes 37:8, pages 889-891.
Crossref
C.L. Baustian & T.J. Mikkelson. (1986) Analysis of clomiphene isomers in human plasma and detection of metabolites using reversed-phase chromatography and fluorescence detection. Journal of Pharmaceutical and Biomedical Analysis 4:2, pages 237-246.
Crossref
J.R. Pasqualini, N. Giambiagi, C. Sumida, B.-L. Nguyen, C. Gelly, C. Mayrand & F. Lecerf. (1986) Biological responses of tamoxifen in the fetal and newborn vagina and uterus of the guinea-pig and in the R-27 mammary cancer cell line. Journal of Steroid Biochemistry 24:1, pages 99-108.
Crossref
John A. Katzenellenbogen, Kathryn E. Carlson & Benita S. Katzenellenbogen. (1985) Facile geometric isomerization of phenolic non-steroidal estrogens and antiestrogens: Limitations to the interpretation of experiments characterizing the activity of individual isomers. Journal of Steroid Biochemistry 22:5, pages 589-596.
Crossref
Carl M. Sutherland, Larry A. Sternson, James H. Muchmore, John E. Ball & Elmo J. Cerise. (1984) Effect of impaired renal function on tamoxifen. Journal of Surgical Oncology 27:4, pages 222-223.
Crossref
C. Paul Daniel, Simon J. Gaskell & Robert I. Nicholson. (1984) The measurement of tamoxifen and metabolites in the rat and relationship to the response of DMBA-induced mammary tumours. European Journal of Cancer and Clinical Oncology 20:1, pages 137-143.
Crossref
B.J.A. Furr & V.C. Jordan. (1984) The pharmacology and clinical uses of tamoxifen. Pharmacology & Therapeutics 25:2, pages 127-205.
Crossref
Noel M. Meltzer, Patrick Stang, Larry A. Sternson & Adelbert E. Wade. (1984) Influence of tamoxifen and its N-desmethyl and 4-hydroxy metabolites on rat liver microsomal enzymes. Biochemical Pharmacology 33:1, pages 115-123.
Crossref
Larry A. Sternson. 1985. Drug Determination in Therapeutic and Forensic Contexts. Drug Determination in Therapeutic and Forensic Contexts 227 234 .
H. K. Adam. 1985. Drug Determination in Therapeutic and Forensic Contexts. Drug Determination in Therapeutic and Forensic Contexts 211 217 .
Peter C. Ruenitz, Jerome R. Bagley & Corwin M. Mokler. (1983) Metabolism of clomiphene in the rat. Biochemical Pharmacology 32:19, pages 2941-2947.
Crossref
Roger R. Reddel & Robert L. Sutherland. (1983) N-Desmethyltamoxifen inhibits growth of MCF 7 human mammary carcinoma cells in Vitro. European Journal of Cancer and Clinical Oncology 19:8, pages 1179-1181.
Crossref
Benita S. Katzenellenbogen, Margaret A. Miller, Richard L. Eckert & Katsuichi Sudo. (1983) Antiestrogen pharmacology and mechanism of action. Journal of Steroid Biochemistry 19:1, pages 59-68.
Crossref
Carlo Maurizio Camaggi, Elena Strocchi, Nadia Canova & Franco Pannuti. (1983) High-performance liquid chromatographic analysis of tamoxifen and major metabolites in human plasma. Journal of Chromatography B: Biomedical Sciences and Applications 275, pages 436-442.
Crossref
BENITA S. KATZENELLENBOGEN, MARGARET A. MILLER, RICHARD L. ECKERT & KATSUICHI SUDO. 1983. Hormonal Steroids. Hormonal Steroids 59 68 .
Shubhra Garg, R.D. Bindal, S. Durani & R.S. Kapil. (1983) Structure-activity relationship of estrogens: A study involving cyclofenyl as the model compound. Journal of Steroid Biochemistry 18:1, pages 89-95.
Crossref
Richard R. Bain & V.Craig Jordan. (1983) Identification of a new metabolite of tamoxifen in patient serum during breast cancer therapy. Biochemical Pharmacology 32:2, pages 373-375.
Crossref
D.J. Bates, A.B. Foster, L.J. Griggs, M. Jarman, G. Leclerco & N. Devleeschouwer. (1982) Metabolism of tamoxifen by isolated rat hepatocytes: anti-estrogenic activity of tamoxifen N-oxide. Biochemical Pharmacology 31:17, pages 2823-2827.
Crossref
V. Craig Jordan & C. Chem.. (1982) Metabolites of tamoxifen in animals and man: Identification, pharmacology, and significance. Breast Cancer Research and Treatment 2:2, pages 123-138.
Crossref
N. Wilking, L.‐E. Appelgren, K. Carlström, Å. Pousette & N. O. Theve. (2009) The Distribution and Metabolism of 14 C‐Labelled Tamoxifen in Spayed Female Mice . Acta Pharmacologica et Toxicologica 50:3, pages 161-168.
Crossref
J Burns & D Rutter(The Late)(The Late). (2006) The preparation of carbon‐14 and tritium labelled 1‐[4‐(2‐dimethylaminoethoxy)phenyl]‐1, 2‐diphenyl‐1‐butene [ICI 46,474, tamoxifen (‘nolvadex’)] and the separation of cis‐trans isomers I. The synthesis of carbon‐14 labelled tamoxifen (‘nolvadex’). Journal of Labelled Compounds and Radiopharmaceuticals 19:2, pages 229-238.
Crossref
David W. Robertson, John A. Katzenellenbogen, Deborah J. Long, Ellen A. Rorke & Benita S. Katzenellenbogen. (1982) Tamoxifen antiestrogens. A comparison of the activity, pharmacokinetics, and metabolic activation of the cis and trans isomers of tamoxifen. Journal of Steroid Biochemistry 16:1, pages 1-13.
Crossref
Benita S. Katzenellenbogen, Ellen A. Rorke & Richard L. Eckert. (1981) Mechanisms of estrogen and antiestrogen action in mammary cancer. Journal of Steroid Biochemistry 15, pages 219-229.
Crossref
Carol Fabian, Lowell Tilzer & Larry Sternson. (2006) Comparative binding affinities of tamoxifen, 4‐hydroxytamoxifen, and desmethyltamoxifen for estrogen receptors isolated from human breast carcinoma: Correlation with blood levels in patients with metastatic breast cancer. Biopharmaceutics & Drug Disposition 2:4, pages 381-390.
Crossref
Peter J. Harman, Graeme L. Blackman & George Phillipou. (1981) High-performance liquid chromatographic determination of clomiphene using post-column on-line photolysis and fluorescence detection. Journal of Chromatography B: Biomedical Sciences and Applications 225:1, pages 131-138.
Crossref
Mels Sluyser, Siegina G. Evers & Cornelis C.J. De Goeij. (1981) Effect of monohydroxytamoxifen on mouse mammary tumors. European Journal of Cancer and Clinical Oncology 17:9, pages 1063-1065.
Crossref
Carol Fabian, Larry Sternson, Moustafa El-serafi, Lyn Cain & Erwin Hearne. (1981) Clinical pharmacology of tamoxifen in patients with breast cancer: Correlation with clinical data. Cancer 48:4, pages 876-882.
Crossref
Paul Daniel, Simon J. Gaskell, Hugh Bishop, Charles Campbell & Robert I. Nicholson. (1981) Determination of tamoxifen and biologically active metabolites in human breast tumours and plasma. European Journal of Cancer and Clinical Oncology 17:11, pages 1183-1189.
Crossref
Peter Wilkinson, Gerald Ribeiro, Hugh Adam & John Patterson. (1980) Clinical pharmacology of tamoxifen and N-desmethyltamoxifen in patients with advanced breast cancer. Cancer Chemotherapy and Pharmacology 5:2, pages 109-111.
Crossref
A.B. Foster, L.J. Griggs, M. Jarman, J.M.S. Van Maanen & H.-R. Schulten. (1980) Metabolism of tamoxifen by rat liver microsomes: formation of the N-oxide, a new metabolite. Biochemical Pharmacology 29:13, pages 1977-1979.
Crossref
Peter C. Ruenitz & Mo M. Toledo. (1980) Inhibition of rabbit liver microsomal oxidative metabolism and substrate binding by tamoxifen and the geometric isomers of clomiphene. Biochemical Pharmacology 29:11, pages 1583-1587.
Crossref
Yechiel Golander & Larry A. Sternson. (1980) Paired-ion chromatographic analysis of tamoxifen and two major metabolites in plasma. Journal of Chromatography B: Biomedical Sciences and Applications 181:1, pages 41-49.
Crossref
G. Leclercq & J.C. Heuson. (1979) Physiological and pharmacological effects of estrogens in breast cancer. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 560:4, pages 427-455.
Crossref
H.M. Bolt. (1979) Metabolism of estrogens—natural and synthetic. Pharmacology & Therapeutics 4:1, pages 155-181.
Crossref
H.K. Adam, E.J. Douglas & J.V. Kemp. (1979) The metabolism of tamoxifen in humans. Biochemical Pharmacology 28:1, pages 145-147.
Crossref
Sewa S. Legha & Stephen K. Carter. (1976) Antiestrogens in the treatment of breast cancer. Cancer Treatment Reviews 3:4, pages 205-216.
Crossref
V.C. Jordan. (1976) Effect of tamoxifen (ICI 46,474) on initiation and growth of DMBA-induced rat mammary carcinomata. European Journal of Cancer (1965) 12:6, pages 419-424.
Crossref

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