Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 3, 1973 - Issue 11
8
Views
52
CrossRef citations to date
0
Altmetric
Research Article

Drug Hydroxylation and Glucuronidation in Liver Microsomes of Phenobarbital-Treated Rats

Pages 715-725 | Received 12 May 1973, Published online: 14 Oct 2008

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

P. Eyer & W. Hell. (1983) The metabolism of 3-benzoylpyridine. Xenobiotica 13:11, pages 649-659.
Read now
Harri Vainio, Max G. Parkki & Jukka Marniemi. (1976) Effects of Aliphatic Chlorohydrocarbons on Drug-metabolizing Enzymes in Rat Liver in vivo. Xenobiotica 6:10, pages 599-604.
Read now

Articles from other publishers (49)

David Zakim & Andrew J. Dannenberg. (1992) How does the microsomal membrane regulate UDP-glucuronosyltransferases?. Biochemical Pharmacology 43:7, pages 1385-1393.
Crossref
DANIEL ACOSTA, DAVID B. MITCHELL, ELSIE M.B. SORENSEN & JAMES V. BRUCKNER. 1987. The Isolated Hepatocyte. The Isolated Hepatocyte 189 214 .
M.Helen morrison & Gabrielle M. Hawksworth. (1984) Glucuronic acid conjugation by hepatic microsomal fractions isolated from streptozotocin-induced diabetic rats. Biochemical Pharmacology 33:23, pages 3833-3838.
Crossref
Tuula Thunberg, Ulf G. Ahlborg & Bo Wahlstr�m. (1984) Comparison between the effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin and six other compounds on the vitamin A storage, the UDP-glucuronosyltransferase and the aryl hydrocarbon hydroxylase activity in the rat liver. Archives of Toxicology 55:1, pages 16-19.
Crossref
Kaija Pyykkö. (1983) Time-course of effects of toluene on microsomal enzymes in rat liver, kidney and lung during and after inhalation exposure. Chemico-Biological Interactions 44:3, pages 299-310.
Crossref
Else-Maj Suolinna, Esko Vänttinen & Antero Aitio. (1982) Induction of aryl hydrocarbon hydroxylase activity in cultured human lymphocytes. Toxicology 24:1, pages 73-84.
Crossref
Eino Hietanen, Antero Aitio, Ulla Koivusaaei, Jukka Kilpiö, Timo Nevalainen, Matti Närhi, Heikki Savolainen & Harri Vainio. (1982) Tissue concentrations and interaction of zinc with lead toxicity in rabbits. Toxicology 25:2-3, pages 113-127.
Crossref
NOBUO NEMOTO. 1981. Polycyclic Hydrocarbons and Cancer. Polycyclic Hydrocarbons and Cancer 213 258 .
Else-Maj Suolinna & Eero Mäntylä. (1980) Glucuronide and sulphate conjugation in isolated liver cells from control and phenobarbital- or PCB-treated rats. Biochemical Pharmacology 29:21, pages 2963-2968.
Crossref
W. Bolanowska & T. Gessner. (1980) Drug interactions with acetaminophen. Biochemical Pharmacology 29:8, pages 1167-1175.
Crossref
Markku Ahotupa & Antero Aitio. (1980) Effect of chlorinated naphthalenes and terphenyls on the activities of drug metabolizing enzymes in rat liver. Biochemical and Biophysical Research Communications 93:1, pages 250-257.
Crossref
Ulla Koivusaari, Matti Lang & Eino Hietanen. (2009) Differences in the Response of Hepatic and Intestinal Drug Metabolizing Enzymes in Rats Following Carbon Tetrachloride and/or Phenobarbital Treatment. Acta Pharmacologica et Toxicologica 46:1, pages 37-42.
Crossref
Eino Hietanen. (1980) Modification of hepatic drug metabolizing enzyme activities and their induction by dietary protein. General Pharmacology: The Vascular System 11:5, pages 443-450.
Crossref
Eino Hietanen, Ulla Koivusaari, Matti Laitinen & Anja Norling. (1980) Hepatic drug metabolism during ethanol ingestion in riboflavin deficient rats. Toxicology 16:2, pages 103-111.
Crossref
Harri Vainio, Jorma Järvisalo & Eero Taskinen. (1979) Adaptive changes caused by intermittent styrene inhalation on xenobiotic biotransformation. Toxicology and Applied Pharmacology 49:1, pages 7-14.
Crossref
Eino Hietanen. (1978) Cadmium-induced tissue specific changes in drug biotransformation rates in rats. Archives of Environmental Contamination and Toxicology 7:1, pages 291-300.
Crossref
Irwin Schmeltz, Jeff Tosk & Gary M. Williams. (1978) Comparison of the metabolic profiles of benzo[a]pyrene obtained from primary cell cultures and subcellular fractions derived from normal and methylcholanthrene-induced rat liver. Cancer Letters 5:2, pages 81-89.
Crossref
Antero Aitio & Max Georg Parkki. (1978) Organ specific induction of drug metabolizing enzymes by 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat. Toxicology and Applied Pharmacology 44:1, pages 107-114.
Crossref
Peter Eyer & Hermann G. Kampffmeyer. (1978) Biotransformation of 4-dimethylaminophenol in the isolated perfused rat liver and in the rat. Biochemical Pharmacology 27:18, pages 2223-2228.
Crossref
Jukka Marniemi, Markku Nokkala, Harri Vainio & Kaarlo J.W. Hartiala. (1977) Stimulation of hepatic drug hydroxylation and conjugation by a cutaneously applied PCB-mixture (Clophen A 50). Chemico-Biological Interactions 18:2, pages 247-251.
Crossref
Janet Wilkinson & Terence Hallinan. (1977) Trypsin-susceptibility of UDP-glucuronyltransferase. FEBS Letters 75:1-2, pages 138-140.
Crossref
Harri Vainio, Jukka Marniemi, Max Parkki & Reijo Luoma. 1977. Biological Reactive Intermediates. Biological Reactive Intermediates 251 262 .
Eino Hietanen & Harri Vainio. (1976) Effect of administration route of ddt on acute toxicity and on drug biotransformation in various rodents. Archives of Environmental Contamination and Toxicology 4:1, pages 201-216.
Crossref
A. Aitio & H. Vainio. (2009) UDPGlucuronosyltransferase and Mixed Function Oxidase Activity in Microsomes Prepared by Differential Centrifugation and Calcium Aggregation. Acta Pharmacologica et Toxicologica 39:5, pages 555-561.
Crossref
Max G. Parkki, Jukka Marniemi & Harri Vainio. (1976) Action of styrene and its metabolites styrene oxide and styrene glycol on activities of xenobiotic biotransformation enzymes in rat liver in vivo. Toxicology and Applied Pharmacology 38:1, pages 59-70.
Crossref
Pekka Uotila & Jukka Marniemi. (1976) Variable effects of cigarette smoking on aryl hydrocarbon hydroxylase, epoxide hydratase and UDP-glucuronosyltransferase activities in rat lung, kidney and small intestinal mucosa. Biochemical Pharmacology 25:20, pages 2323-2328.
Crossref
Peter Moldéus, Helena Vadi & Margareta Berggren. (2009) Oxidative and Conjugative Metabolism of p –Nitroanisole and p –Nitrophenol in Isolated Rat Liver Cells . Acta Pharmacologica et Toxicologica 39:1, pages 17-32.
Crossref
Erik Dybing. (1976) Inhibition of acetaminophen glucuronidation by oxazepam. Biochemical Pharmacology 25:12, pages 1421-1425.
Crossref
Nobuo Nemoto & Harry V. Gelboin. (1976) Enzymatic conjugation of benzo(a)pyrene oxides, phenols and dihydrodiols with UDP-glucuronic acid. Biochemical Pharmacology 25:10, pages 1221-1226.
Crossref
Harri Vainio & Max G. Parkki. (1976) Enhancement of microsomal monooxygenase, epoxide hydrase and udpglucuronyltransferase by aldrin, dieldrin and isosafrole administrations in rat liver. Toxicology 5:3, pages 279-286.
Crossref
H. Vainio. 1976. Mechanisms of Toxicity and Metabolism. Mechanisms of Toxicity and Metabolism 53 66 .
Geoffrey J. Dutton. (1975) Control of UDP-glucuronyltransferase activity. Biochemical Pharmacology 24:20, pages 1835-1841.
Crossref
Jukka Marniemi, Antero Aitio & Harri Vainio. (2009) Ethanol Induced Alteration of Microsomal Membrane Bound Enzymes of Rat Liver in Vitro . Acta Pharmacologica et Toxicologica 37:3, pages 222-232.
Crossref
E. Hietanen, M. Laitinen, H. Vainio & O. Hänninen. (1975) Dietary fats and properties of endoplasmic reticulum: II. Dietary lipid induced changes in activities of drug metabolizing enzymes in liver and duodenum of rat. Lipids 10:8, pages 467-472.
Crossref
Harri Vainio & Antero Aitio. (2009) Influence of Hematin, Carbon Tetrachloride and SKF 525‐A Administration on the Enhancement of Microsomal Monooxygenase and UDPglucuronosyltransferase by 3,4‐Benzpyrene in Rat Liver. Acta Pharmacologica et Toxicologica 37:1, pages 23-32.
Crossref
Jukka Marniemi & Matti Laitinen. (1975) Regulatory properties of partially purified udpglucuronosyltransferase (p-nitrophenol). International Journal of Biochemistry 6:5, pages 345-352.
Crossref
Harri Vainio. (2009) Comparison of the Activities of Drug-metabolizing Enzymes in End-term Foetal and Maternal Livers of the Rabbit. Acta Pharmacologica et Toxicologica 36:1, pages 91-96.
Crossref
Harri Vainio & Eino Hietanen. (1974) Drug metabolism in gunn rats: Inability to increase bilirubin glucuronidation by phenobarbital treatment. Biochemical Pharmacology 23:24, pages 3405-3412.
Crossref
Harri Vainio. (1974) Enhancement of microsomal drug oxidation and glucuronidation in rat liver by an environmental chemical, polychlorinated biphenyl. Chemico-Biological Interactions 9:5, pages 379-387.
Crossref
Harri Vainio & Eino Hietanen. (1974) Induction deficiency of the microsomal UDPglucuronosyltransferase by 3-methylcholanthrene in Gunn rats. Biochimica et Biophysica Acta (BBA) - General Subjects 362:1, pages 92-99.
Crossref
Jukka Marniemi. (1974) Bilirubin UDP-glucosyl- and UDP-glucuronosyltransferase of rat liver. A comparative study of the effects of membrane perturbants in vitro and of chrysene administration in vivo. Chemico-Biological Interactions 9:2, pages 135-143.
Crossref
H. Vainio & O. Hänninen. (2009) A Comparative Study on Drug Hydroxylation and Glucuronidation in Liver Microsomes of Phenobarbital and 3‐Methylcholanthrene Treated Rats. Acta Pharmacologica et Toxicologica 35:1, pages 65-75.
Crossref
Antero Aitio. (1974) Effect of various membrane perturbating agents on the UDP-glucuronosyltransferase activity in different rat tissues. International Journal of Biochemistry 5:7-8, pages 617-621.
Crossref
Harri Vainio. (1974) Enhancement of hepatic microsomal drug oxidation and glucuronidation in rat by 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT). Chemico-Biological Interactions 9:1, pages 7-14.
Crossref
Antero Aitio. (1974) Effect of chrysene and carbon tetrachloride administration on rat hepatic microsomal monooxygenase and UDPglucuronosyltransferase activity. FEBS Letters 42:1, pages 46-49.
Crossref
Anja Norling & O. Hänninen. (1974) Activation energy of glucuronide biosynthesis. Biochimica et Biophysica Acta (BBA) - Enzymology 350:1, pages 183-192.
Crossref
Harri Vainio. (2009) Activation and Inactivation of Membrane‐Bound UDP‐glucuronosyltransferase by Organic Solvents in Vitro . Acta Pharmacologica et Toxicologica 34:3, pages 152-156.
Crossref
Harri Vainio & Antero Aitio. (2009) Enhancement of Microsomal Drug Hydroxylation and Glucuronidation in Rat Liver by Phenobarbital and 3‐Methylcholanthrene in Combination. Acta Pharmacologica et Toxicologica 34:2, pages 130-140.
Crossref
H. Vainio, A. Aitio & O. Hänninen. (1974) Action of transcription and translation inhibitors on the enhancement of drug hydroxylation and glucuronidation by 3-methylcholanthrene and phenobarbital. International Journal of Biochemistry 5:2, pages 193-200.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.