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Xenobiotica
the fate of foreign compounds in biological systems
Volume 3, 1973 - Issue 12
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Research Article

The Metabolism of Sympathomimetic Bronchodilator Drugs by the Isolated Perfused Dog Lung

Robin H. Briant M.R.C. Clinical Pharmacology Research Group, Royal Postgraduate Medical School, London, W.12
,
Elaine W. Blackwell M.R.C. Clinical Pharmacology Research Group, Royal Postgraduate Medical School, London, W.12
,
Faith M. Williams M.R.C. Clinical Pharmacology Research Group, Royal Postgraduate Medical School, London, W.12
,
Donald S. Davies M.R.C. Clinical Pharmacology Research Group, Royal Postgraduate Medical School, London, W.12
&
Colin T. Dollery M.R.C. Clinical Pharmacology Research Group, Royal Postgraduate Medical School, London, W.12
Pages 787-799 | Received 16 Jun 1973, Published online: 14 Oct 2008

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Åke Ryrfeldt & Nils-Olov Bodin. (1975) The Physiological Disposition of Ibuterol, Terbutaline and Isoproterenol after Endotracheal Instillation to Rats. Xenobiotica 5:9, pages 521-529.
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Faith M. Williams, Robin H. Briant, C. T. Dollery & D. S. Davies. (1974) The Influence of the Route of Administration on Urinary Metabolites of Isoetharine. Xenobiotica 4:6, pages 345-353.
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Articles from other publishers (29)

Marianne Widman, Marianne Nordqvist, Colin T DolleryRobin H Briant. (1975) Metabolism of Δ1-tetrahydrocannabinol by the isolated perfused dog lung. Comparison with in vitro liver metabolism . Journal of Pharmacy and Pharmacology 27:11, pages 842-848.
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Stephen Davis. 2007. xPharm: The Comprehensive Pharmacology Reference. xPharm: The Comprehensive Pharmacology Reference 1 7 .
LARS BORGSTRÖM. (1998) Local Versus Total Systemic Bioavailability as a Means to Compare Different Inhaled Formulations of the Same Substance. Journal of Aerosol Medicine 11:1, pages 55-63.
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UNA S. RYAN & ALBERT P. LI. 1993. Metabolic Activation and Toxicity of Chemical Agents to Lung Tissue and Cells. Metabolic Activation and Toxicity of Chemical Agents to Lung Tissue and Cells 107 122 .
Sylvie Perreault, Huy Ong & Patrick du Souich. (1992) Salbutamol disposition and dynamics in conscious rabbits: Influence of the route of administration and of the dose. Journal of Pharmacokinetics and Biopharmaceutics 20:5, pages 461-476.
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Glyn Taylor. (1990) The absorption and metabolism of xenobiotics in the lung. Advanced Drug Delivery Reviews 5:1-2, pages 37-61.
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G M Cohen. (1990) Pulmonary metabolism of foreign compounds: its role in metabolic activation.. Environmental Health Perspectives 85, pages 31-41.
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Una S. Ryan & Christopher J. Grantham. (1989) Metabolism of endogenous and xenobiotic substances by pulmonary vascular endothelial cells. Pharmacology & Therapeutics 42:2, pages 235-250.
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M. E. Conolly. 1989. Catecholamines II. Catecholamines II 357 389 .
Vincent Li. 1987. Controlled Drug Delivery. Controlled Drug Delivery 3 94 .
Alain F. Junod. 2011. Comprehensive Physiology. Comprehensive Physiology 337 349 .
R.K. Brazzell, R.B. Smith & H.B. Kostenbauder. (1982) Isolated Perfused Rabbit Lung As a Model for Intravascular and Intrabronchial Administration of Bronchodilator Drugs I: Isoproterenol. Journal of Pharmaceutical Sciences 71:11, pages 1268-1274.
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Charles F. George. 1982. Presystemic Drug Elimination. Presystemic Drug Elimination 189 205 .
P.A. Routledge. 1982. Presystemic Drug Elimination. Presystemic Drug Elimination 173 185 .
Y.S. Bakhle. 1982. Presystemic Drug Elimination. Presystemic Drug Elimination 147 172 .
Jerry M. Collins & Robert L. Dedrick. (1982) Contribution of Lungs to Total Body Clearance: Linear and Nonlinear Effects. Journal of Pharmaceutical Sciences 71:1, pages 66-70.
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Harihara M. Mehendale, Linda S. Angevine & Yoshio Ohmiya. (1981) The isolated perfused lung — A critical evaluation. Toxicology 21:1, pages 1-36.
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Claes Post. (2009) Studies on the Pharmacokinetic Function of the Lung with Special Reference to Lidocaine. Acta Pharmacologica et Toxicologica 44, pages 1-53.
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Lewis S. Schanker. (1978) Drug absorption from the lung. Biochemical Pharmacology 27:4, pages 381-385.
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Åke Ryrfeldt & Elisabeth Nilsson. (1978) Uptake and biotransformation of ibuterol and terbutaline in isolated perfused rat and guinea pig lungs. Biochemical Pharmacology 27:3, pages 301-305.
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Y. S. Bakhle. 1977. Principles of Surgical Oncology. Principles of Surgical Oncology 47 65 .
Per Andersson. (2009) Bronchospasmolytic and Cardiovascular Effects in Anaesthetized Cats of Ibuterol and Terbutaline Given Intravenously and after Inhalation: Drug and Prodrug Compared. Acta Pharmacologica et Toxicologica 39:2, pages 225-231.
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GILLIAN M. SHENFIELD, MARION E. EVANS & J.W. PATERSON. (1976) ABSORPTION OF DRUGS BY THE LUNG. British Journal of Clinical Pharmacology 3:4, pages 583-589.
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Ake Ryrfeldt & Elisabeth Nilsson. (2009) Physiological Disposition of Ibuterol and Terbutaline in the Isolated Perfused Rat Lung. Acta Pharmacologica et Toxicologica 39:1, pages 39-45.
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Antero Aitio. (1976) Glucuronide conjugation in the lung. Agents and Actions 6:4, pages 531-533.
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Alain Junod. (1976) Uptake, release and metabolism of drugs in the lungs. Pharmacology & Therapeutics. Part B: General and Systematic Pharmacology 2:3, pages 511-521.
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Francis C.P. Law, John C. Drach & Joseph E. Sinsheimer. (1975) Pulmonary O-methyl transferases. Biochemical Pharmacology 24:3, pages 385-390.
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D.S. Davies. 1975. Lung Metabolism. Lung Metabolism 201 217 .
E.W. BLACKWELL, R.H. BRIANT, M.E. CONOLLY, D.S. DAVIES & C.T. DOLLERY. (1974) METABOLISM OF ISOPRENALINE AFTER AEROSOL AND DIRECT INTRABRONCHIAL ADMINISTRATION IN MAN AND DOG. British Journal of Pharmacology 50:4, pages 587-591.
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