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Xenobiotica
the fate of foreign compounds in biological systems
Volume 4, 1974 - Issue 3
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Research Article

Inhibition of the Metabolism of N-Substituted Amphetamines by SKF 525-A and Related Compounds

Michael R. Franklin Department of Biopharmaceutical Sciences, College of Pharmacy, University of Utah, Salt Lake City, Utah, 84112, U.S.A.
Pages 143-150 | Received 13 Jul 1973, Published online: 14 Oct 2008

Citations (19)

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Michael Murray. (1987) Mechanisms of the Inhibition of Cytochrome P 450-Mediated Drug Oxidation by Therapeutic Agents. Drug Metabolism Reviews 18:1, pages 55-81.
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Articles from other publishers (18)

Richard E. Armer, Jacqueline S. Barlow, Christopher J. Dutton, David H.J. Greenway, Sean D.W. Greenwood, Nita Lad, Adrian P. Thompson, Kam-Wah Thong & Ivan Tommasini. (1998) 8-Aminoquinolines as anticoccidials — II. Bioorganic & Medicinal Chemistry Letters 8:12, pages 1487-1492.
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Michael Murray & Susan L. Field. (1992) Inhibition and metabolite complexation of rat hepatic microsomal cytochrome p450 by tricyclic antidepressants. Biochemical Pharmacology 43:10, pages 2065-2071.
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P.L. Iversen, Z. Liu & M.R. Franklin. (1985) Selective changes in cytochrome P-450 and UDP-glucuronosyltransferase subpopulations following partial hepatectomy in rats. Toxicology and Applied Pharmacology 78:1, pages 10-18.
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Aalt Bast, E. Maria Savenije−Chapel & Jan Noordhoek. (1984) Relationship Between Molecular Structure and Cytochrome P450−Metabolic Intermediate Complex Formation. Journal of Pharmaceutical Sciences 73:7, pages 953-956.
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Zahra Parandoosh & Michael R. Franklin. (1983) Developmental changes in rabbit pulmonary cytochrome P-450 subpopulations. Life Sciences 33:13, pages 1255-1260.
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Aalt Bast & Jan Noordhoek. (1982) Spectral interaction of orphenadrine and its metabolites with oxidized and reduced hepatic microsomal cytochrome P-450 in the rat. Biochemical Pharmacology 31:17, pages 2745-2753.
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Dominique Pessayre, Veronique Descatoire, Mitka Konstantinova-Mitcheva, Joao-Carlos Wandscheer, Barton Cobert, Regine Level, Jean-Pierre Benhamou, Maryse Jaouen & Daniel Mansuy. (1981) Self-induction by triacetyloleandomycin of its own transformation into a metabolite forming a stable 456 nm-absorbing complex with cytochrome P-450. Biochemical Pharmacology 30:6, pages 553-558.
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Robert Snyder & Herbert Remmer. (1979) Classes of hepatic microsomal mixed function oxidase inducers. Pharmacology & Therapeutics 7:2, pages 203-244.
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Alan R. Dahl & Ernest Hodgson. (1978) Complexes of trivalent oxygenated phosphorus compounds with cytochrome P-450 and cytochrome P-420: The origin of double Soret spectra. Chemico-Biological Interactions 21:2-3, pages 137-154.
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Robert C. James & Michael R. Franklin. (1978) The triphasic amphetamine lethal dose curve in mice and its possible relationship to drug metabolism. Toxicology and Applied Pharmacology 44:1, pages 63-73.
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Arthur K. Cho & Jeremy Wright. (1978) Pathways of metabolism of amphetamine and related compounds. Life Sciences 22:5, pages 363-371.
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Neal CastagnoliJr.Jr.. 1978. Stimulants. Stimulants 335 387 .
Michael R. Franklin. 1977. Microsomes and Drug Oxidations. Microsomes and Drug Oxidations 284 291 .
Michael R. Franklin. (1977) Inhibition of mixed-function oxidations by substrates forming reduced cytochrome P-450 metabolic-intermediate complexes. Pharmacology & Therapeutics. Part A: Chemotherapy, Toxicology and Metabolic Inhibitors 2:1, pages 227-245.
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Michael R. Franklin. (1976) A new class of inhibitory cytochrome P-450 complexes formed during metabolism: A comparison with amphetamine and SKF 525-A type complexes. Chemico-Biological Interactions 14:3-4, pages 337-346.
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D. Mansuy, P. Beaune, J.C. Chottard, J.F. Bartoli & P. Gans. (1976) The nature of the “455 nm absorbing complex” formed during the cytochrome P450 dependent oxidative metabolism of amphetamine. Biochemical Pharmacology 25:5, pages 609-612.
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Robert C. James & Michael R. Franklin. (1975) Comparisons of the formation of cytochrome P-450 complexes absorbing at 455 nm in rabbit and rat microsomes. Biochemical Pharmacology 24:8, pages 835-838.
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Jurgen Werringloer & Ronald W. Estabrook. (1975) Heterogeneity of liver microsomal cytochrome P-450: The spectral characterization of reactants with reduced cytochrome P-450. Archives of Biochemistry and Biophysics 167:1, pages 270-286.
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