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Xenobiotica
the fate of foreign compounds in biological systems
Volume 4, 1974 - Issue 3
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Research Article

Metabolism of Chloroform—II. A Sex Difference in the Metabolism of [14C]Chloroform in Mice

D. C. Taylor Beecham Research Laboratories, Medicinal Research Centre, Fourth Avenue, Harlow, Essex, U.K.
,
D. M. Brown Beecham Research Laboratories, Medicinal Research Centre, Fourth Avenue, Harlow, Essex, U.K.
,
R. Keeble Beecham Research Laboratories, Medicinal Research Centre, Fourth Avenue, Harlow, Essex, U.K.
&
P. F. Langley Beecham Research Laboratories, Medicinal Research Centre, Fourth Avenue, Harlow, Essex, U.K.
Pages 165-174 | Received 26 Jun 1973, Published online: 14 Oct 2008

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Makoto Take, Seigo Yamamoto, Makoto Ohnishi, Michiharu Matsumoto, Kasuke Nagano, Takashi Hirota & Shoji Fukushima. (2010) Chloroform distribution and accumulation by combined inhalation plus oral exposure routes in rats. Journal of Environmental Science and Health, Part A 45:12, pages 1616-1624.
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M. E. (Bette) Meek, John R. Bucher, Samuel M. Cohen, Vicki Dellarco, Richard N. Hill, Lois D. Lehman-McKeeman, David G. Longfellow, Timothy Pastoor, Jennifer Seed & Dorothy E. Patton. (2003) A Framework for Human Relevance Analysis of Information on Carcinogenic Modes of Action. Critical Reviews in Toxicology 33:6, pages 591-653.
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M. E. Meek, R. Beauchamp, G. Long, D. Moir, L. Turner & M. Walker. (2002) CHLOROFORM: EXPOSURE ESTIMATION, HAZARD CHARACTERIZATION, AND EXPOSURE-RESPONSE ANALYSIS. Journal of Toxicology and Environmental Health, Part B 5:3, pages 283-334.
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Glenn F. Rush, Jacqueline H. Smith, John F. Newton, Jerry B. Hook & William O. Berndt. (1984) Chemically Induced Nephrotoxicity: Role of Metabolic Activation. CRC Critical Reviews in Toxicology 13:2, pages 99-160.
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Kerstin Bergman & Lars-Erik Appelgren. (1983) Application and Results of Whole-Body Autoradiography in Distribution Studies of Organic Solvents. CRC Critical Reviews in Toxicology 12:1, pages 59-118.
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I. W. F. Davidson, D. D. Sumner & J. C. Parker. (1982) Chloroform: A Review of Its Metabolism, Teratogenic, Mutagenic, and Carcinogenic Potential. Drug and Chemical Toxicology 5:1, pages 1-87.
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D. M. Brown, P. F. Langley, D. Smith & D. C. Taylor. (1974) Metabolism of Chloroform—I. The Metabolism of [14C] Chloroform by Different Species. Xenobiotica 4:3, pages 151-163.
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Gordon C. Hard. (2016) Mechanisms of Chemically Induced Renal Carcinogenesis in the Laboratory Rodent. Toxicologic Pathology 26:1, pages 104-112.
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. (1994) Appendix B: Chlorinated alkanes. Regulatory Toxicology and Pharmacology 20:1, pages S671-S756.
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Elizabeth K. Weisburger. 1989. Mechanisms of Carcinogenesis. Mechanisms of Carcinogenesis 51 53 .
E. A. Lock. 1987. Nephrotoxicity in the experimental and clinical situation. Nephrotoxicity in the experimental and clinical situation 429 461 .
Annabel G. Liebelt. 1986. Urinary System. Urinary System 24 44 .
P. Kjellstrand, M. Bjerkemo, M. Adler‐Maihofer & B. Holmquist. (2009) Effects of Solvent Exposure on Testosterone Levels and Butyrylcholinesterase Activity in Mice. Acta Pharmacologica et Toxicologica 57:4, pages 242-249.
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Jacqueline H. Smith, Keizo Maita, Stuart D. Sleight & Jerry B. Hook. (1984) Effect of sex hormone status on chloroform nephrotoxicity and renal mixed function oxidases in mice. Toxicology 30:4, pages 305-316.
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Edward A. Lock, John Ishmael & Jerry B. Hook. (1984) Nephrotoxicity of hexachloro-1,3-butadiene in the mouse: The effect of age, sex, strain, monooxygenase modifiers, and the role of glutathione. Toxicology and Applied Pharmacology 72:3, pages 484-494.
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M. Mercier, M. Lans & J. de Gerlache. 1984. Mutagenicity, Carcinogenicity, and Teratogenicity of Industrial Pollutants. Mutagenicity, Carcinogenicity, and Teratogenicity of Industrial Pollutants 281 324 .
Jacqueline H. Smith & Jerry B. Hook. (1983) Mechanism of chloroform nephrotoxicity. Toxicology and Applied Pharmacology 70:3, pages 480-485.
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Jacqueline H. Smith, Keizo Maita, Stuart D. Sleight & Jerry B. Hook. (1983) Mechanism of chloroform nephrotoxicity. Toxicology and Applied Pharmacology 70:3, pages 467-479.
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David W. Yesair. (2016) The Importance of Pharmacokinetic Principles in Characterizing Carcinogenic Thresholds for Naturally Occurring and Synthetic Chemicals. Journal of the American College of Toxicology 2:3, pages 55-72.
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William M. Kluwe & Jerry B. Hook. (1981) Potentiation of acute chloroform nephrotoxicity by the glutathione depletor diethyl maleate and protection by the microsomal enzyme inhibitor piperonyl butoxide. Toxicology and Applied Pharmacology 59:3, pages 457-466.
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Faye J. Bowman, Joseph F. Borzelleca & Albert E. Munson. (1978) The toxicity of some halomethanes in mice. Toxicology and Applied Pharmacology 44:1, pages 213-215.
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Richard N. Hill. (1977) DIFFERENTIAL TOXICITY OF CHLOROFORM IN THE MOUSE. Annals of the New York Academy of Sciences 298:1 Aquatic Pollu, pages 170-176.
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Richard N. Hill, Thomas L. Clemens, Dai Kee Liu, Elliot S. Vesell & W. Dean Johnson. (1975) Genetic Control of Chloroform Toxicity in Mice. Science 190:4210, pages 159-161.
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Frans C. Goble. 1975. 173 252 .

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