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Xenobiotica
the fate of foreign compounds in biological systems
Volume 4, 1974 - Issue 5
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Research Article

Studies on Metabolism of Trazodone, I. Metabolic Fate of [14C]Trazodone Hydrochloride in Rats

C. Yamato Department of Drug Metabolism, Section of Experimental Therapeutics Research, Research & Development Division, Eisai Co. Ltd., 4-chome, Koishikawa, Bunkyo-ku, Tokyo, Japan
,
T. Takahashi Department of Drug Metabolism, Section of Experimental Therapeutics Research, Research & Development Division, Eisai Co. Ltd., 4-chome, Koishikawa, Bunkyo-ku, Tokyo, Japan
&
T. Fujita Department of Drug Metabolism, Section of Experimental Therapeutics Research, Research & Development Division, Eisai Co. Ltd., 4-chome, Koishikawa, Bunkyo-ku, Tokyo, Japan
Pages 313-326 | Received 17 Oct 1973, Published online: 14 Oct 2008

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Shu-Feng Zhou, Jun-Ping Liu & Balram Chowbay. (2009) Polymorphism of human cytochrome P450 enzymes and its clinical impact. Drug Metabolism Reviews 41:2, pages 89-295.
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C. Yamato, T. Takahashi & T. Fujita. (1976) Studies on Metabolism of Trazodone IV. Intestinal Absorption in Rats and Rabbits. Xenobiotica 6:9, pages 521-529.
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C. Yamato, T. Takahashi & T. Fujita. (1976) Studies on Metabolism of Trazodone. III. Species Differences. Xenobiotica 6:5, pages 295-306.
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C. Yamato, T. Takahashi, T. Fujita, S. Kuriyama & N. Hirose. (1974) Studies on Metabolism of Trazodone, II. Metabolic Fate after Intravenous Administration and Effects on Liver Microsomal Drug-Metabolizing Enzymes in Rats. Xenobiotica 4:12, pages 765-777.
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Articles from other publishers (17)

Bernd Reichl, Markus Himmelsbach, Lisa Emhofer, Christian W. Klampfl & Wolfgang Buchberger. (2018) Uptake and metabolism of the antidepressants sertraline, clomipramine, and trazodone in a garden cress ( Lepidium sativum ) model . ELECTROPHORESIS 39:9-10, pages 1301-1308.
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Kim A. Johnson, Stella Huang & Yue‐Zhong Shu. 2012. ADME‐Enabling Technologies in Drug Design and Development. ADME‐Enabling Technologies in Drug Design and Development 353 362 .
S Caccia, M H Fong, S Garattini & M G Zanini. (1982) Plasma concentrations of trazodone and 1-(3-chlorophenyl)piperazine in man after a single oral dose of trazodone. Journal of Pharmacy and Pharmacology 34:9, pages 605-606.
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S Caccia, M Ballabio, R Samanin, M G Zanini & S Garattini. (1981) (—)-m-Chlorophenyl-piperazine, a central 5-hydroxytryptamine agonist, is a metabolite of trazodone. Journal of Pharmacy and Pharmacology 33:1, pages 477-478.
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M Melzacka, J Boksa & J Maj. (1979) l-( m -Chlorophenyl)piperazine: a metabolite of trazodone isolated from rat urine . Journal of Pharmacy and Pharmacology 31:1, pages 855-856.
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Kim A. Johnson, Xiaohong Liu, Stella Huang, Vikram Roongta, W. Griffith Humphreys & Yue-Zhong Shu. (2010) Rapid structure determination of microgram-level drug metabolites using HPLC-MS, fraction collection and NMR spectroscopy. Analytical Methods 2:10, pages 1542.
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John C. L. Erve, Chad E. Beyer, Lawrence Manzino & Rasmy E. Talaat. (2009) Metabolite identification in rat brain microdialysates by direct infusion nanoelectrospray ionization after desalting on a ZipTip and LTQ/Orbitrap mass spectrometry. Rapid Communications in Mass Spectrometry 23:24, pages 4003-4012.
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Mingshe Zhu & Bo Wen. 2009. 59 98 .
Marta Pazzagli, Maria Grazia Giovannini & Giancarlo Pepeu. (1999) Trazodone increases extracellular serotonin levels in the frontal cortex of rats. European Journal of Pharmacology 383:3, pages 249-257.
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Hemmie H. G. Berendsen, François Jenck & Chris L. E. Broekkamp. (1990) Involvement of 5-HT1C-receptors in drug-induced penile erections in rats. Psychopharmacology 101:1, pages 57-61.
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R. T. Coutts & G. B. Baker. (1989) Implications of chirality and geometric isomerism in some psychoactive drugs and their metabolites. Chirality 1:2, pages 99-120.
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Dennis K.J. Gorecki & Roger K. Verbeeck. 1987. 693 730 .
S. Caccia, M. Ballabio, R. Fanelli, G. Guiso & M.G. Zanini. (1981) Determination of plasma and brain concentrations of trazodone and its metabolite, l-m-chlorophenylpiperazine, by gas-liquid chromatography. Journal of Chromatography A 210:2, pages 311-318.
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M.M. Al-Yassiri, S.I. Ankier & P.K. Bridges. (1981) Trazodone - a new antidepressant. Life Sciences 28:22, pages 2449-2458.
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Duncan P. Taylor, Deborah K. Hyslop & Leslie A. Riblet. (1980) Trazodone, a new nontricyclic antidepressant without anticholinergic activity. Biochemical Pharmacology 29:15, pages 2149-2150.
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J. Maj, W. Palider & A. Raw?�w. (1979) Trazodone, a central serotonin antagonist and agonist. Journal of Neural Transmission 44:3, pages 237-248.
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G. Belvedere, A. Frigerio & C. Pantarotto. (1975) Gas chromatographic-mass fragmentographic determination of trazodone in rat plasma. Journal of Chromatography A 112, pages 631-636.
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