Advanced search
Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 4, 1974 - Issue 12
Submit an article Journal homepage
23
Views
9
CrossRef citations to date
0
Altmetric
Research Article

Studies on Metabolism of Trazodone, II. Metabolic Fate after Intravenous Administration and Effects on Liver Microsomal Drug-Metabolizing Enzymes in Rats

C. Yamato Department of Drug Metabolism, Section of Experimental Therapeutics Research, and Section of Organic Chemistry, Tokyo, Japan
,
T. Takahashi Department of Drug Metabolism, Section of Experimental Therapeutics Research, and Section of Organic Chemistry, Tokyo, Japan
,
T. Fujita Department of Drug Metabolism, Section of Experimental Therapeutics Research, and Section of Organic Chemistry, Tokyo, Japan
,
S. Kuriyama Research and Development Division, Eisai Co., Ltd., 4-chome, Koishikawa, Bunkyo-ku, Tokyo, Japan
&
N. Hirose Research and Development Division, Eisai Co., Ltd., 4-chome, Koishikawa, Bunkyo-ku, Tokyo, Japan
Pages 765-777 | Received 25 Apr 1974, Published online: 22 Sep 2008

Citations (9)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (2)

C. Yamato, T. Takahashi & T. Fujita. (1976) Studies on Metabolism of Trazodone IV. Intestinal Absorption in Rats and Rabbits. Xenobiotica 6:9, pages 521-529.
Read now
C. Yamato, T. Takahashi & T. Fujita. (1976) Studies on Metabolism of Trazodone. III. Species Differences. Xenobiotica 6:5, pages 295-306.
Read now

Articles from other publishers (7)

M Melzacka, J Boksa & J Maj. (1979) l-( m -Chlorophenyl)piperazine: a metabolite of trazodone isolated from rat urine . Journal of Pharmacy and Pharmacology 31:1, pages 855-856.
Crossref
Jen-Chih Chang, Yu-Tse Wu, Wen-Chuan Lee, Lie-Chwen Lin & Tung-Hu Tsai. (2009) Herb–drug interaction of silymarin or silibinin on the pharmacokinetics of trazodone in rats. Chemico-Biological Interactions 182:2-3, pages 227-232.
Crossref
Bo Wen, Li Ma, A. David Rodrigues & Mingshe Zhu. (2008) Detection of Novel Reactive Metabolites of Trazodone: Evidence for CYP2D6-Mediated Bioactivation of m -Chlorophenylpiperazine . Drug Metabolism and Disposition 36:5, pages 841-850.
Crossref
Amit S. Kalgutkar, Kirk R. Henne, Mary E. Lame, Alfin D.N. Vaz, Claire Collin, John R. Soglia, Sabrina X. Zhao & Cornelis E.C.A. Hop. (2005) Metabolic activation of the nontricyclic antidepressant trazodone to electrophilic quinone-imine and epoxide intermediates in human liver microsomes and recombinant P4503A4. Chemico-Biological Interactions 155:1-2, pages 10-20.
Crossref
Koichi Otani, Kazuo Mihara, Norio Yasui, Masayuki Ishida, Tsuyoshi Kondo, Noboru Tokinaga, Tadashi Ohkubo, Takako Osanai, Kazunobu Sugawara & Sunao Kaneko. (1997) Plasma concentrations of trazodonb and m-chlorophenylpiperazine at steady state can be predicted from those after an initial dose of trazodone. Progress in Neuro-Psychopharmacology and Biological Psychiatry 21:1, pages 239-244.
Crossref
M.M. Al-Yassiri, S.I. Ankier & P.K. Bridges. (1981) Trazodone - a new antidepressant. Life Sciences 28:22, pages 2449-2458.
Crossref
J. Maj, W. Palider & A. Raw?�w. (1979) Trazodone, a central serotonin antagonist and agonist. Journal of Neural Transmission 44:3, pages 237-248.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.