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Xenobiotica
the fate of foreign compounds in biological systems
Volume 4, 1974 - Issue 11
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Research Article

The Disposition and Metabolism of Amodiaquine in Small Mammals

A. Barrow Postgraduate School of Pharmaceutical Chemistry, The University, Bradford, BD7 1DP, Yorkshire, UK
Pages 669-680 | Received 10 Apr 1974, Published online: 22 Sep 2008

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H. Jewell, J. L. Maggs, A. C. Harrison, P. M. O'neill, J. E. Ruscoe & B. K. Park. (1995) Role of hepatic metabolism in the bioactivation and detoxication of amodiaquine. Xenobiotica 25:2, pages 199-217.
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Articles from other publishers (16)

Yongjie Zhang, Shalenie P. den Braver-Sewradj, Michiel W. den Braver, Steven Hiemstra, Nico P. E. Vermeulen, Bob van de Water, Jan N. M. Commandeur & J. C. Vos. (2018) Glutathione S-Transferase P1 Protects Against Amodiaquine Quinoneimines-Induced Cytotoxicity but Does Not Prevent Activation of Endoplasmic Reticulum Stress in HepG2 Cells. Frontiers in Pharmacology 9.
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P A Winstanley, G Edwards, C G Curtis, M L'E Orme, G M Powell & A M Breckenridge. (1988) Tissue Distribution and Excretion of Amodiaquine in the Rat. Journal of Pharmacy and Pharmacology 40:5, pages 343-349.
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E. Pussard & F. Verdier. (2009) Antimalarial 4‐aminoquinolines: mode of action and pharmacokinetics. Fundamental & Clinical Pharmacology 8:1, pages 1-17.
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Anthony C. Harrison, Neil R. Kitteringham, Janet B. Clarke & B.Kevin Park. (1992) The mechanism of bioactivation and antigen formation of amodiaquine in the rat. Biochemical Pharmacology 43:7, pages 1421-1430.
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J. Elks & C. R. Ganellin. 1990. Dictionary of Drugs. Dictionary of Drugs 1 118 .
F VerdierE PussardF ClavierJ Le BrasC Gaudebout. (1989) Pharmacokinetics of intramuscular amopyroquin in healthy subjects and determination of a therapeutic regimen for Plasmodium falciparum malaria. Antimicrobial Agents and Chemotherapy 33:3, pages 316-321.
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E PussardF VerdierF FaurissonF ClavierF SimonC Gaudebout. (1988) Disposition of amopyroquin in rats and rabbits and in vitro activity against Plasmodium falciparum. Antimicrobial Agents and Chemotherapy 32:4, pages 568-572.
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J.L. Maggs, M.D. Tingle, N.R. Kitteringham & B.K. Park. (1988) Drug-protein conjugates?XIV. Biochemical Pharmacology 37:2, pages 303-311.
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J.L. Maggs, N.R. Kitteringham, A.M. Breckenridge & B.K. Park. (1987) Autoxidative formation of a chemically reactive intermediate from amodiaquine, a myelotoxin and hepatotoxin in man. Biochemical Pharmacology 36:13, pages 2061-2062.
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NJ White, S Looareesuwan, G Edwards, RE Phillips, J Karbwang, DD Nicholl, C Bunch & DA Warrell. (2012) Pharmacokinetics of intravenous amodiaquine.. British Journal of Clinical Pharmacology 23:2, pages 127-135.
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P Winstanley, G Edwards, M Orme & A Breckenridge. (2012) The disposition of amodiaquine in man after oral administration.. British Journal of Clinical Pharmacology 23:1, pages 1-7.
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Eric Pussard, Francoise Verdier & Marie-Claude Blayo. (1986) Simultaneous determination of chloroquine, amodiaquine and their metabolites in human plasma, red blood cells, whole blood and urine by column liquid chromatography. Journal of Chromatography B: Biomedical Sciences and Applications 374, pages 111-118.
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Frederick C. Churchill, Leslie C. Patchen, Carlos C. Campbell, Ira K. Schwartz, Phuc Nguyen-Dinh & Charlotte M. Dickinson. (1985) Amodiaquine as a prodrug: Importance of metabolite(s) in the antimalarial effect of amodiaquine in humans. Life Sciences 36:1, pages 53-62.
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E. W. McChesney & C. D. Fitch. 1984. Antimalarial Drug II. Antimalarial Drug II 3 60 .
Kelvin Ma & Theodore L. Sourkes. (1980) Inhibition of diamine oxidase by antimalarial drugs. Agents and Actions 10:5, pages 395-398.
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Donald C. Hobbs & Hugh M. Mcllhenny. 1976. Annual Reports in Medicinal Chemistry Volume 11. Annual Reports in Medicinal Chemistry Volume 11 190 199 .

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