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Xenobiotica
the fate of foreign compounds in biological systems
Volume 4, 1974 - Issue 11
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Research Article

In Vitro Metabolism of p-Xylene by Rabbit Lung and Liver

Matthew F. Carlone Department of Pharmacology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA; Pharmacology Branch, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina, 27709, USA
&
James R. Fouts Department of Pharmacology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA; Pharmacology Branch, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina, 27709, USA
Pages 705-715 | Received 28 Apr 1974, Published online: 22 Sep 2008

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MaryjaneK. Selgrade, MaryJ. Daniels, RichardH. Jaskot, BarbaraL. Robinson & JohnW. Allis. (1993) Enhanced mortality and liver damage in virus‐infected mice exposed to p‐xylene. Journal of Toxicology and Environmental Health 40:1, pages 129-144.
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W. L. Backes, D. J. Sequeira, G. F. Cawley & C. S. Eyer. (1993) Relationship between hydrocarbon structure and induction of P450: effects on protein levels and enzyme activities. Xenobiotica 23:12, pages 1353-1366.
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E. Elovaara. (1982) Dose-related effects of m-xylene inhalation on the xenobiotic metabolism of the rat. Xenobiotica 12:6, pages 345-352.
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E. Elovaara, Y. Collan, P. Pfäffli & H. Vainio. (1980) The combined toxicity of technical grade xylene and ethanol in the rat. Xenobiotica 10:6, pages 435-445.
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Articles from other publishers (23)

Alexander V. LyubimovShalu Jhajra, Ninad Ramesh Varkhede, Deepak Suresh Ahire, Bukke Vidyasagar Naik, Bhagwat Prasad, Jyoti Paliwal & Saranjit Singh. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 99 .
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. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 264 285 .
. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 1 19 .
. 2002. The MAK-Collection for Occupational Health and Safety. The MAK-Collection for Occupational Health and Safety 1 318 .
. 2002. The MAK-Collection for Occupational Health and Safety. The MAK-Collection for Occupational Health and Safety 264 276 .
Rogene F. Henderson. 2003. Patty's Toxicology. Patty's Toxicology.
Mike Fay, Carol Eisenmann, Sanjivani Diwan & Christopher De Rosa. (2016) ATSDR Evaluation of Health Effects of Chemicals. V. Xylenes: Health Effects, Toxicokinetics, Human Exposure, and Environmental Fate. Toxicology and Industrial Health 14:5, pages 571-766.
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Andreas Langner. (2006) Ersatz‐ und Ergänzungsmethoden zur Untersuchung der Biotransformation von Arzneistoffen. Pharmazie in unserer Zeit 24:4, pages 207-218.
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S. Padilla, D.L. Lyerly & C.N. Pope. (1992) Subacute ethanol consumption reverses p-xylene-induced decreases in axonal transport. Toxicology 75:2, pages 159-167.
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Lawrence Fishbein. (1985) An overview of environmental and toxicological aspects of aromatic hydrocarbons III. Xylene. Science of The Total Environment 43:1-2, pages 165-183.
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M Wallen, S Holm & M B Nordqvist. (1985) Coexposure to toluene and p-xylene in man: uptake and elimination.. Occupational and Environmental Medicine 42:2, pages 111-116.
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T. E. Gram. 1985. Toxicology of Inhaled Materials. Toxicology of Inhaled Materials 421 470 .
V. Riihim�ki, K. Savolainen, P. Pf�ffli, K. Pekari, H. W. Sippel & A. Laine. (1982) Metabolic interaction between m-xylene and ethanol. Archives of Toxicology 49:3-4, pages 253-263.
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E. Elovaara, P. Pfäffli, H. Savolainen & H. Vainio. (2006) Marginal role of impaired aldehyde metabolism in m ‐xylene vapour‐induced biochemical effects in the rat . Journal of Applied Toxicology 2:1, pages 27-32.
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Gary E.R. Hook. 1982. Presystemic Drug Elimination. Presystemic Drug Elimination 117 146 .
Francis C.P. Law & Esther M.K. So. (1981) Induction studies of ?1-tetrahydrocannabinol metabolism by rat and rabbit lungs. Comparative Biochemistry and Physiology Part C: Comparative Pharmacology 69:1, pages 19-23.
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H. Savolainen, P. Pfäffli, M. Helojoki & M. Tengén. (2009) Neurochemical and Behavioural Effects of Long‐term Intermittent Inhalation of Xylene Vapour and Simultaneous Ethanol Intake. Acta Pharmacologica et Toxicologica 44:3, pages 200-207.
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J. M. Patel, C. Harper, B. N. Gupta & R. T. Drew. (1979) Changes in serum enzymes after inhalation exposure ofp-Xylene. Bulletin of Environmental Contamination and Toxicology 21:1, pages 17-24.
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Arun C. Dey & Ian R. Senciall. (1978) Acidic steroid metabolites: Biosynthesis of steroid carboxylic acids by rabbit liver microsomes and the involvement of a cytochrome P450-independent mixed function oxidase system. Journal of Steroid Biochemistry 9:11, pages 1099-1104.
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H. Savolainen, H. Vainio, M. Helojoki & E. Elovaara. (1978) Biochemical and toxicological effects of short-term, intermittent xylene inhalation exposure and combined ethanol intake. Archives of Toxicology 41:3, pages 195-205.
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C. Harper, R. T. Drew & J. R. Fouts. 1977. Biological Reactive Intermediates. Biological Reactive Intermediates 302 311 .
C. Harper, M. O. James, T. R. Devereux, J. M. Patel, J. R. Bend & J. R. Fouts. (1976) Characteristics and development of drug metabolism by pulmonary microsomes. Agents and Actions 6:4, pages 527-530.
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