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Xenobiotica
the fate of foreign compounds in biological systems
Volume 4, 1974 - Issue 1
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Research Article

Metabolism of 8-Chloro-6-phenyl-4H-s-triazolo[4,3-α][1,4]-benzodiazepine (D–40TA), a New Central Depressant. I. Absorption, Distribution and Excretion in Rats

Shigeharu Tanayama Biological Research Labororaties, Central Research Division, Takeda Chemical Industries Ltd., Juso, Higashiyodogawa-ku, Osaka, Japan
,
Yoshihiro Shirakawa Biological Research Labororaties, Central Research Division, Takeda Chemical Industries Ltd., Juso, Higashiyodogawa-ku, Osaka, Japan
,
Yoshio Kanai Biological Research Labororaties, Central Research Division, Takeda Chemical Industries Ltd., Juso, Higashiyodogawa-ku, Osaka, Japan
&
Ziro Suzuoki Biological Research Labororaties, Central Research Division, Takeda Chemical Industries Ltd., Juso, Higashiyodogawa-ku, Osaka, Japan
Pages 33-47 | Received 01 May 1973, Published online: 22 Sep 2008

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Yuu Moriya, Akifumi Kogame, Yoshihiko Tagawa, Akio Morohashi, Takahiro Kondo & Satoru Asahi. (2019) Investigation of disposition for TAK-448, a synthetic peptide of kisspeptin analog, in rats and dogs using the radiolabeled TAK-448 suitable for pharmacokinetic study. Xenobiotica 49:7, pages 833-839.
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Takuo Kobayashi, Hideaki Hohnoki, Yoshio Esumi, Toshiharu Ohtsuki, Tohru Washino & Shigeharu Tanayama. (1988) Metabolism and disposition of (RS)-2-methoxy-3-(octadecylcarbamoyloxy)propyl 2-(3-thiazolio)ethyl phosphate (MOTP) in rats and dogs. Xenobiotica 18:1, pages 49-59.
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J. M. Machinist, B. A. Bopp, D. J. Anderson, G. R. Granneman, R. C. Sonders, K. Tolman, K. Buchi & D. Rollins. (1986) Metabolism of 14C-estazolam in dogs and humans. Xenobiotica 16:1, pages 11-20.
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A. Mancinelli, G. Guiso, S. Garattini, R. Urso & S. Caccia. (1985) Kinetic and pharmacological studies on estazolam in mice and man. Xenobiotica 15:3, pages 257-265.
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H. Torii, K. Yoshida, T. Tsukamoto & S. Tanayama. (1984) Disposition in rats and dogs of ciglitazone, a new antidiabetic agent. Xenobiotica 14:3, pages 259-268.
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H. P. A. Illing, R. M. J. Ings, K. I. Johnson & J. M. Fromson. (1983) Disposition of 14C-loprazolam in animals and man. Xenobiotica 13:7, pages 439-449.
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H. Kitagawa, Y. Esumi, S. Kurosawa, S. Sekine & T. Yokoshima. (1979) Metabolism of 8-chloro-6-(o-chlorophenyl)-1-methyl-4H-s-triazolo [4,3-a] [1,4]benzodiazepine, triazolam, a new central depressant. II. Identification and determination of metabolites in rats and dogs. Xenobiotica 9:7, pages 429-439.
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Shigeharu Tanayama, Takuo Kobayashi & Yoshio Kanai. (1978) Metabolism of 3-(2′,4′,5′-Triethoxybenzoyl)propionic Acid, a New Biliary Smooth Muscle Relaxant with Choleretic Activity: I. Disposition after a Single Administration in Rats and Dogs. Xenobiotica 8:6, pages 365-375.
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Shigeharu Tanayama, Sachiko Momose & Yoshio Kanai. (1974) Comparative Studies on the Metabolic Disposition of 8-Chloro-6-pheny1–4H-s-triazolo[4,3-a][1,4]benzo-diazepine (D-40TA) and Nitrazepam after Single and Repeated Administration in Rats. Xenobiotica 4:4, pages 229-236.
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Shigeharu Tanayama, Sachiko Momose, Yoshio Kanai & Yoshihiro Shirakawa. (1974) Metabolism of 8-Chloro-6-phenyl-4H-s-triazolo[4,3-a]-[1,4]benzodiazepine (D-40TA), a New Central Depressant. IV. Placental Transfer and Excretion in Milk in Rats. Xenobiotica 4:4, pages 219-227.
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Yoshio Kanai. (1974) The Biotransformation of 8-Chloro-6-phenyl-4H-s-triazolo[4, 3-a][1,4] benzodiazepine (D-40TA), a New Central Depressant, in Man, Dog and Rat. Xenobiotica 4:7, pages 441-456.
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Shigeharu Tanayama, Sachiko Momose & Etsuko Takagaki. (1974) Metabolism of 8-Chloro-6-phenyl-4H-s-triazolo[4,3-α][1,4]-benzodiazepine (D–40TA), a New Central Depressant. III. Metabolism and Tolerance Studies in Rats. Xenobiotica 4:1, pages 57-65.
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Shigeharu Tanayama & Yoshio Kanai. (1974) Metabolism of 8-Chloro-6-phenyl-4H-s-triazolo[4,3-α][1,4]-benzodiazepine (D–40TA), a New Central Depressant. II. Species Difference in Metabolism. Xenobiotica 4:1, pages 49-56.
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Articles from other publishers (10)

John A. Timbrell & Timothy C. Marrs. 2009. General, Applied and Systems Toxicology. General, Applied and Systems Toxicology.
Phung D. Le, André J. A. Aarnink, Nico W. M. Ogink, Petra M. Becker & Martin W. A. Verstegen. (2007) Odour from animal production facilities: its relationship to diet. Nutrition Research Reviews 18:1, pages 3-30.
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Hartmund Wollweber. 2003. Ullmann's Encyclopedia of Industrial Chemistry. Ullmann's Encyclopedia of Industrial Chemistry.
Yoshihiko Tagawa, Kiyoshi Miwa, Kenji Yamashita, Ryoichi Tsukuda, Yoshinobu Yoshimura, Shigeharu Tanayama & Yusuke Tanigawara. (1999) Possible factor for nonlinear pharmacokinetics of TAK‐603, a new antirheumatic agent, in rats. Biopharmaceutics & Drug Disposition 20:1, pages 11-18.
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K Yoshida, M Mitani, I Naeshiro, H Torii & S Tanayama. (1986) Disposition of carumonam (AMA-1080/Ro 17-2301), a new N-sulfonated monocyclic beta-lactam, in rats and dogs. Antimicrobial Agents and Chemotherapy 29:6, pages 1017-1024.
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S. Tanayama, K. Yoshida, T. Kondo & Y. Kanai. (1979) Disposition and metabolism of 16?-ethyl-17?-hydroxy-4-estren-3-one (TSAA-291), a new antiandrogen, in rats. Steroids 33:1, pages 65-83.
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Shigeharu Tanayama, Kiyoshi Yoshida & Yoshio Kanai. (1978) Metabolic Fate of SCE-129, a New Antipseudomonal Cephalosporin, After Parenteral Administration in Rats and Dogs. Antimicrobial Agents and Chemotherapy 14:1, pages 137-143.
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Sierk F. Spoelstra. (1977) Simple phenols and indoles in anaerobically stored piggery wastes. Journal of the Science of Food and Agriculture 28:5, pages 415-423.
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D. J. Back & Jagmohan K. G. Singh. (1976) The biliary excretion of [3H] lysergic acid diethylamide in Wistar and gunn rats. Experientia 32:5, pages 616-617.
Crossref
Willard M. Welch & Charles A. Harbert. 1975. 2 11 .

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