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Xenobiotica
the fate of foreign compounds in biological systems
Volume 4, 1974 - Issue 1
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Research Article

Metabolism of 8-Chloro-6-phenyl-4H-s-triazolo[4,3-α][1,4]-benzodiazepine (D–40TA), a New Central Depressant. III. Metabolism and Tolerance Studies in Rats

Shigeharu Tanayama Biological Research Labororaties, Central Research Division, Takeda Chemical Industries Ltd., Juso, Higashiyodogawa-ku, Osaka, Japan
,
Sachiko Momose Biological Research Labororaties, Central Research Division, Takeda Chemical Industries Ltd., Juso, Higashiyodogawa-ku, Osaka, Japan
&
Etsuko Takagaki Biological Research Labororaties, Central Research Division, Takeda Chemical Industries Ltd., Juso, Higashiyodogawa-ku, Osaka, Japan
Pages 57-65 | Received 01 May 1973, Published online: 22 Sep 2008

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H. Kitagawa, Y. Esumi, S. Kurosawa, S. Sekine & T. Yokoshima. (1979) Metabolism of 8-chloro-6-(o-chlorophenyl)-1-methyl-4H-s-triazolo [4,3-a] [1,4]benzodiazepine, triazolam, a new central depressant. II. Identification and determination of metabolites in rats and dogs. Xenobiotica 9:7, pages 429-439.
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H. Kitagawa, Y. Esumi, S. Kurosawa, S. Sekine & T. Yokoshima. (1979) Metabolism of 8-chloro-6-(o-chlorophenyl)-1-methyl- 4H-s-triazolo [4,3-a] [1,4] benzodiazepine, triazolam, a new central depressant. I. Absorption, distribution and excretion in rats, dogs and monkeys. Xenobiotica 9:7, pages 415-428.
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Shigeharu Tanayama, Sachiko Momose & Yoshio Kanai. (1974) Comparative Studies on the Metabolic Disposition of 8-Chloro-6-pheny1–4H-s-triazolo[4,3-a][1,4]benzo-diazepine (D-40TA) and Nitrazepam after Single and Repeated Administration in Rats. Xenobiotica 4:4, pages 229-236.
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Shigeharu Tanayama, Sachiko Momose, Yoshio Kanai & Yoshihiro Shirakawa. (1974) Metabolism of 8-Chloro-6-phenyl-4H-s-triazolo[4,3-a]-[1,4]benzodiazepine (D-40TA), a New Central Depressant. IV. Placental Transfer and Excretion in Milk in Rats. Xenobiotica 4:4, pages 219-227.
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Shigeharu Tanayama, Yoshihiro Shirakawa, Yoshio Kanai & Ziro Suzuoki. (1974) Metabolism of 8-Chloro-6-phenyl-4H-s-triazolo[4,3-α][1,4]-benzodiazepine (D–40TA), a New Central Depressant. I. Absorption, Distribution and Excretion in Rats. Xenobiotica 4:1, pages 33-47.
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Shigeharu Tanayama. (1974) Metabolism of 6-Chloro-5-cyclohexylindan-1-carboxylic Acid (TAI-284), a New Non-steroidal Anti-inflammatory Agent, in Relation to Ulcerogenic Activity. Xenobiotica 4:10, pages 617-626.
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Articles from other publishers (3)

W H DOWND R HAWKINSL F CHASSEAUD. (1982) Effect of the triazolobenzodiazepine estazolam on hepatic drug-metabolizing enzyme activity in rats. Journal of Pharmacy and Pharmacology 34:7, pages 434-437.
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A. D. Lê & Jatinder M. Khanna. 1989. Psychoactive Drugs. Psychoactive Drugs 281 351 .
Peter Elsass, J�rn Hendel, Eigill F. Hvidberg, Tage Hansen, Erik Gymoese & J�rgen Rathje. (1980) Kinetics and neuropsychologic effects of IV diazepam in the presence and absence of its active N-desmethyl metabolite in humans. Psychopharmacology 70:3, pages 307-312.
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