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Xenobiotica
the fate of foreign compounds in biological systems
Volume 4, 1974 - Issue 8
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Research Article

Metabolism of N-Acylated and O-Alkylated Drugs by the Intestinal Microflora During Anaerobic Incubation in vitro

G. E. Smith Department of Biochemistry, University of Birmingham, P.O. Box 363, Birmingham, B15 2TT, UK
&
L. A. Griffiths Department of Biochemistry, University of Birmingham, P.O. Box 363, Birmingham, B15 2TT, UK
Pages 477-487 | Received 06 Feb 1974, Published online: 22 Sep 2008

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Dong-Hyun Kim. (2023) Interaction of drugs with gut microbiota modulators. Drug Metabolism Reviews 55:3, pages 181-194.
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Yuan Xie, Fangdi Hu, Dawei Xiang, Hui Lu, Wenbin Li, Anpeng Zhao, Longji Huang & Rong Wang. (2020) The metabolic effect of gut microbiota on drugs. Drug Metabolism Reviews 52:1, pages 139-156.
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Emma L. McConnell, Fang Liu & Abdul W. Basit. (2009) Colonic treatments and targets: issues and opportunities. Journal of Drug Targeting 17:5, pages 335-363.
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J. O. Nwankwo. (1991) In vitro O-demethylation from a heterocyclic nitrogen: A novel metabolic reaction?. Xenobiotica 21:5, pages 569-574.
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Glenn F. Rush, Jacqueline H. Smith, John F. Newton, Jerry B. Hook & William O. Berndt. (1984) Chemically Induced Nephrotoxicity: Role of Metabolic Activation. CRC Critical Reviews in Toxicology 13:2, pages 99-160.
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S. C. Mitchell, H. M. Norbury, R. H. Waring, P. M. Gadsden & P. B. Wood. (1982) A comparison of the metabolism and elimination of benzanilide and salicylanilide in the rat. Xenobiotica 12:2, pages 93-99.
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R. H. Clothier, Jane R. Dewar, Maria Ana Santos, A. D. North, Susan Foster & M. Balls. (1981) A comparative study of the deacetylation of paracetamol by urodele and anuran amphibian organ cultures. Xenobiotica 11:3, pages 149-157.
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G. E. Smith & L. A. Griffiths. (1976) Comparative Metabolic Studies of Phenacetin and Structurally-related Compounds in the Rat. Xenobiotica 6:4, pages 217-236.
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Articles from other publishers (26)

Zehra Esra Ilhan & Melissa M. Herbst-Kralovetz. 2022. Metabolism of Nutrients by Gut Microbiota. Metabolism of Nutrients by Gut Microbiota 120 149 .
Susannah Selber-Hnatiw. 2022. Comprehensive Gut Microbiota. Comprehensive Gut Microbiota 46 68 .
Aishwarya Naik & Santosh K. Misra. (2021) Modern Sensing Approaches for Predicting Toxicological Responses of Food- and Drug-Based Bioactives on Microbiomes of Gut Origin. Journal of Agricultural and Food Chemistry 69:23, pages 6396-6413.
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Samantha M. Ervin, Siddharth Venkat Ramanan & Aadra P. Bhatt. (2020) Relationship Between the Gut Microbiome and Systemic Chemotherapy. Digestive Diseases and Sciences 65:3, pages 874-884.
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Joseph L. Dempsey & Julia Yue Cui. (2019) Microbiome Is a Functional Modifier of P450 Drug Metabolism. Current Pharmacology Reports 5:6, pages 481-490.
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Juanhong Zhang, Junmin Zhang, Rong Wang & Zhengping Jia. (2019) Effects of Gut Microbiota on Drug Metabolism and Guidance for Rational Drug Use Under Hypoxic Conditions at High Altitudes. Current Drug Metabolism 20:2, pages 155-165.
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Jordan E. Bisanz, Peter Spanogiannopoulos, Lindsey M. Pieper, Annamarie E. Bustion & Peter J. Turnbaugh. (2018) How to Determine the Role of the Microbiome in Drug Disposition. Drug Metabolism and Disposition 46:11, pages 1588-1595.
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Min Sun Choi, Jun Sang Yu, Hye Hyun Yoo & Dong-Hyun Kim. (2018) The role of gut microbiota in the pharmacokinetics of antihypertensive drugs. Pharmacological Research 130, pages 164-171.
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Jared W. Castle, Danielle M. Butzbach, G. Stewart Walker, Claire E. Lenehan, Frank Reith & K. Paul Kirkbride. 2017. Forensic Microbiology. Forensic Microbiology 212 244 .
Ian D. Wilson & Jeremy K. Nicholson. (2017) Gut microbiome interactions with drug metabolism, efficacy, and toxicity. Translational Research 179, pages 204-222.
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Lenka Jourova, Pavel Anzenbacher & Eva Anzenbacherova. (2016) Human gut microbiota plays a role in the metabolism of drugs. Biomedical Papers 160:3, pages 317-326.
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Lian Yee Yip & Eric Chun Yong Chan. (2015) Investigation of Host–Gut Microbiota Modulation of Therapeutic Outcome. Drug Metabolism and Disposition 43:10, pages 1619-1631.
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Ian D. Wilson & Jeremy K. Nicholson. 2015. Metabonomics and Gut Microbiota in Nutrition and Disease. Metabonomics and Gut Microbiota in Nutrition and Disease 323 341 .
Henry J. Haiser & Peter J. Turnbaugh. (2013) Developing a metagenomic view of xenobiotic metabolism. Pharmacological Research 69:1, pages 21-31.
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Corinne?Ferrier Maurice, Henry?Joseph Haiser & Peter?James Turnbaugh. (2013) Xenobiotics Shape the Physiology and Gene Expression of the Active Human Gut Microbiome. Cell 152:1-2, pages 39-50.
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Hye Gwang Jeong, Mi Jeong Kang, Hyung Gyun Kim, Do Gyeong Oh, Jin Sung Kim, Sang Kyu Lee & Tae Cheon Jeong. (2012) Role of intestinal microflora in xenobiotic‐induced toxicity. Molecular Nutrition & Food Research 57:1, pages 84-99.
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Tiago Sousa, Ronnie Paterson, Vanessa Moore, Anders Carlsson, Bertil Abrahamsson & Abdul W. Basit. (2008) The gastrointestinal microbiota as a site for the biotransformation of drugs. International Journal of Pharmaceutics 363:1-2, pages 1-25.
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A P Mikhalkin. (1995) The synthesis, properties, and applications of N -acyl-α-aminoacids . Russian Chemical Reviews 64:3, pages 259-275.
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Alice M. Clark, Robert T. Clinton, John K. Baker & Charles D. Hufford. (1983) Demethylation of Imipramine by Enteric Bacteria. Journal of Pharmaceutical Sciences 72:11, pages 1288-1290.
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J.F. Newton, C.-H. Kuo, M.W. Gemborys, G.H. Mudge & J.B. Hook. (1982) Nephrotoxicity of p-aminophenol, a metabolite of acetaminophen, in the Fischer 344 rat. Toxicology and Applied Pharmacology 65:2, pages 336-344.
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A.G. Renwick. 1982. Presystemic Drug Elimination. Presystemic Drug Elimination 3 28 .
Richard H. Clothier, Michael Balls, Gary S. Hostry, Neil J. Robertson & Steven A. Horner. (1982) Amphibian organ culture in experimental toxicology: The effects of paracetamol and phenacetin on cultured tissues from urodele and anuran amphibians. Toxicology 25:1, pages 31-40.
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G. C. Bolton & L. A. Griffiths. (1978) Metabolism of hydrazines and hydrazides by the intestinal microflora. Experientia 34:11, pages 1484-1486.
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R.A. PRINS. 1978. Nutrition and Drug Interrelations. Nutrition and Drug Interrelations 189 251 .
G. E. Smith & L. A. Griffiths. (1976) Metabolism of a biliary metabolite of phenacetin and other acetanilides by the intestinal microflora. Experientia 32:12, pages 1556-1557.
Crossref
Donald C. Hobbs & Hugh M. Mcllhenny. 1976. Annual Reports in Medicinal Chemistry Volume 11. Annual Reports in Medicinal Chemistry Volume 11 190 199 .

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