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Xenobiotica
the fate of foreign compounds in biological systems
Volume 4, 1974 - Issue 4
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Research Article

The effects of 1-alkylimidazoles on hepatic drug-metabolizing enzyme activity

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Pages 209-217 | Received 28 Jul 1973, Published online: 14 Oct 2008

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Lev M. Weiner. (1986) Magnetic Resonance Study of the Structure and Functions of Cytochrome P45. Critical Reviews in Biochemistry 20:2, pages 139-200.
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Bernard Testa & Peter Jenner. (1981) Inhibitors of Cytochrome P-450s and Their Mechanism of Action. Drug Metabolism Reviews 12:1, pages 1-117.
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Articles from other publishers (23)

Lorne J. Brandes, Gary M. Queen & Frank S. LaBella. (1998) Potent interaction of histamine and polyamines at microsomal cytochrome P450, nuclei, and chromatin from rat hepatocytes. Journal of Cellular Biochemistry 69:3, pages 233-243.
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Michael H. Tarbit, William R. Robertson & Ann Lambert. 1990. Chemotherapy of Fungal Diseases. Chemotherapy of Fungal Diseases 205 229 .
Laurence Laignelet, Jean-Francois Narbonne, Jean-Claude Lhuguenot & Jean-Louis Riviere. (1989) Induction and inhibition of rat liver cytochrome(s) P-450 by an imidazole fungicide (prochloraz). Toxicology 59:3, pages 271-284.
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Stephen A. Ballard, Alberto Lodola & Michael H. Tarbit. (1988) A comparative study of 1-substituted imidazole and 1,2,4-triazole antifungal compounds as inhibitors of testosterone hydroxylations catalysed by mouse hepatic musomal cytochromes P-450. Biochemical Pharmacology 37:24, pages 4643-4651.
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J.Brian Houston, Michael J. Humphrey, Diana E. Matthew & Michael H. Tarbit. (1988) Comparison of two azole antifungal drugs, ketoconazole and fluconazole, as modifiers of rat hepatic monooxygenase activity. Biochemical Pharmacology 37:3, pages 401-408.
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Iván bélai, GyöRgy Matolcsy, Dan E. Farnsworth & René Feyereisen. (2006) Inhibition of insect cytochrome P‐450 by some metyrapone analogues and compounds containing a cyclopropylamine moiety and their evaluation as inhibitors of juvenile hormone biosynthesis. Pesticide Science 24:3, pages 205-219.
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A.D. Rodrigues, G.G. Gibson, C. Ioannides & D.V. Parke. (1987) Interactions of imidazole antifungal agents with purified cytochrome P-450 proteins. Biochemical Pharmacology 36:24, pages 4277-4281.
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Terry D. Lindstrom, Gary W. Whitaker & Richard P. Pioch. (1987) Inhibition of microsomal biotransformation by a series of nitrogen and oxygen heterocyclic histamine h2-antagonists. Biochemical Pharmacology 36:10, pages 1669-1672.
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Francis Y.F. Lee, Paul Workman & Kevin H. Cheeseman. (1987) Misonidazole and benznidazole inhibit hydroxylation of ccnu by mouse liver microsomal cytochrome P-450 in vitro. Biochemical Pharmacology 36:8, pages 1349-1355.
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Francis Y.F. Lee & Paul Workman. (1986) Interaction of nitroimidazole sensitizers with drug metabolizing enzymes?Spectral and kinetic studies. International Journal of Radiation Oncology*Biology*Physics 12:8, pages 1383-1387.
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D.J. Back & J.F. Tjia. (2012) Inhibition of tolbutamide metabolism by substituted imidazole drugs in vivo : evidence for a structure‐activity relationship . British Journal of Pharmacology 85:1, pages 121-126.
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Matthew J. Henry & Hugh D. Sisler. (1984) Effects of sterol biosynthesis-inhibiting (SBI) fungicides on cytochrome P-450 oxygenations in fungi. Pesticide Biochemistry and Physiology 22:3, pages 262-275.
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C.K. Chang & T.W. Jordan. (1983) Inhibition of permethrin-hydrolyzing esterases from Wiseana cervinata larvae. Pesticide Biochemistry and Physiology 19:2, pages 190-195.
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Christopher F. Wilkinson, Krystyna Hetnarski, Michael S. Denison & Frederick P. Guengerich. (1983) Selectivity of 1-phenylimidazole as a ligand for cytochrome P-450 and as an inhibitor of microsomal oxidation. Biochemical Pharmacology 32:6, pages 997-1003.
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Jean-Louis Rivière. (1983) Prochloraz, a potent inducer of the microsomal cytochrome P-450 system. Pesticide Biochemistry and Physiology 19:1, pages 44-52.
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Peter J. Little & Adrian J. Ryan. (1982) Inhibitors of hepatic mixed function oxidases—V. Inhibition of aminopyrine N-demethylation and enhancement of aniline hydroxylation by benzoxazole derivatives. Biochemical Pharmacology 31:9, pages 1795-1798.
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Maurice Dickins & James W. Bridges. (1982) The relationship between the binding of 2-n-alkylbenzimidazoles to rat hepatic microsomal cytochrome P-450 and the inhibition of monooxygenation. Biochemical Pharmacology 31:7, pages 1315-1320.
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Peter J. Little, Margeret O. James, John R. Bend & Adrian J. Ryan. (1981) Imidazole derivatives as inhibitors of cytochrome P-450-dependent oxidation and activators of epoxide hydrolase in hepatic microsomes from a marine fish. Biochemical Pharmacology 30:20, pages 2876-2880.
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Robert Snyder & Herbert Remmer. (1979) Classes of hepatic microsomal mixed function oxidase inducers. Pharmacology & Therapeutics 7:2, pages 203-244.
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Leverett R. Smith & C.F. Wilkinson. (1978) Inhibition of microsomal oxidation by some bis(imidazolyl) derivatives. Biochemical Pharmacology 27:9, pages 1383-1384.
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T.D. Rogerson, C.F. Wilkinson & Krystyna Hetarski. (1977) Steric factors in the inhibitory interaction of imidazoles with microsomal enzymes. Biochemical Pharmacology 26:11, pages 1039-1042.
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Gerald M. Holder, Peter J. Little, Adrian J. Ryan & Thomas R. Watson. (1976) Inhibitors of hepatic mixed function oxidases—II Some benzimidazole, benzoxazole and benzothiazole derivatives. Biochemical Pharmacology 25:24, pages 2747-2750.
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Michael N. Eakins, Peter J. Conroy, Andrew J. Searle, Trevor F. Slater & Robin L. Willson. (1976) Metronidazole (flagyl), a radiosensitiser of possible clinical use in cancer chemotherapy: Some biochemical and pharmacological considerations. Biochemical Pharmacology 25:10, pages 1151-1156.
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