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Xenobiotica
the fate of foreign compounds in biological systems
Volume 5, 1975 - Issue 5
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Research Article

Nephrotoxicity and Molecular Structure

I. C. Calder Departments of Chemistry and Pathology, University of Melbourne, Parkville, Victoria, 3052, Australia
,
P. J. Williams Departments of Chemistry and Pathology, University of Melbourne, Parkville, Victoria, 3052, Australia
,
R. A. Woods Departments of Chemistry and Pathology, University of Melbourne, Parkville, Victoria, 3052, Australia
,
C. C. Funder Departments of Chemistry and Pathology, University of Melbourne, Parkville, Victoria, 3052, Australia
,
C. R. Green Departments of Chemistry and Pathology, University of Melbourne, Parkville, Victoria, 3052, Australia
,
K. N. Ham Departments of Chemistry and Pathology, University of Melbourne, Parkville, Victoria, 3052, Australia
&
J. D. Tange Departments of Chemistry and Pathology, University of Melbourne, Parkville, Victoria, 3052, Australia
 show all
Pages 303-307 | Received 17 Feb 1974, Accepted 10 Jan 1975, Published online: 22 Sep 2008

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Glenn F. Rush, Jacqueline H. Smith, John F. Newton, Jerry B. Hook & William O. Berndt. (1984) Chemically Induced Nephrotoxicity: Role of Metabolic Activation. CRC Critical Reviews in Toxicology 13:2, pages 99-160.
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Robert P. Hanzlik. (1982) Effects of Substituents on Reactivity and Toxicity of Chemically Reactive Intermediates. Drug Metabolism Reviews 13:2, pages 207-234.
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R. H. Clothier, Jane R. Dewar, Maria Ana Santos, A. D. North, Susan Foster & M. Balls. (1981) A comparative study of the deacetylation of paracetamol by urodele and anuran amphibian organ cultures. Xenobiotica 11:3, pages 149-157.
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Articles from other publishers (25)

George E. Burrows & Ronald J. Tyrl. 2012. Toxic Plants of North America. Toxic Plants of North America 675 689 .
Suk K. Hong, Dianne K. Anestis, John G. Ball, Monica A. Valentovic, Patrick I. Brown & Gary O. Rankin. (1997) 4-Amino-2,6-Dichlorophenol Nephrotoxicity in the Fischer 344 Rat: Protection by Ascorbic Acid, AT-125, and Aminooxyacetic Acid. Toxicology and Applied Pharmacology 147:1, pages 115-125.
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Suk K. Hong, Monica A. Valentovic, Dianne K. Anestis, John G. Ball, Patrick I. Brown & Gary O. Rankin. (1996) Nephrotoxicity of 4-amino-2-chlorophenol and 2-amino-4-chlorophenol in the Fischer 344 rat. Toxicology 110:1-3, pages 47-58.
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P. J. O’Brien, S. Jatoe, L. G. McGirr & S. Khan. 1991. N-Oxidation of Drugs. N-Oxidation of Drugs 217 236 .
L Staerk Laursen, M Stokholm, K Bukhave, J Rask-Madsen & K Lauritsen. (1990) Disposition of 5-aminosalicylic acid by olsalazine and three mesalazine preparations in patients with ulcerative colitis: comparison of intraluminal colonic concentrations, serum values, and urinary excretion.. Gut 31:11, pages 1271-1276.
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C.M. Burnett, T.A. Re, S. Rodriguez, R.F. Loehr & W.E. Dressler. (1989) The toxicity of p-Aminophenol in the Sprague-Dawley rat: Effects on growth, reproduction and foetal development. Food and Chemical Toxicology 27:10, pages 691-698.
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STIG BONDESEN, STEN NØRBY RASMUSSEN, JØRGEN RASK‐MADSEN, OLE HAAGEN NIELSEN, KARSTEN LAURITSEN, VIBEKE BINDER, STEEN HONORÉ HANSEN & EIGILL F. HVIDBERG. (2009) 5‐Aminosalicylic Acid in the Treatment of Inflammatory Bowel Disease. Acta Medica Scandinavica 221:3, pages 227-242.
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Ulrich Diener, Hans-Volker Tuczek, Christine Fischer, Karlernst Maier & Ulrich Klotz. (1984) Renal function was not impaired by treatment with 5-aminosalicylic acid in rats and man. Naunyn-Schmiedeberg's Archives of Pharmacology 326:3, pages 278-282.
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Haagen O Nielsen & S Bondesen. (2012) Kinetics of 5‐aminosalicylic acid after jejunal instillation in man.. British Journal of Clinical Pharmacology 16:6, pages 738-740.
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S.N. Rasmussen, Vibeke Binder, K. Maier, S. Bondesen, Christine Fischer, U. Klotz, S. Honoré Hansen & E.F. Hvidberg. (1983) Treatment of Crohn's Disease With Peroral 5-Aminosalicylic Acid. Gastroenterology 85:6, pages 1350-1353.
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M. Balls & R. Clothier. (2009) Differentiated cell and organ culture in toxicity testing.. Acta Pharmacologica et Toxicologica 52, pages 115-137.
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S.N. Rasmussen, S. Bondesen, E.F. Hvidberg, S. Honoré Hansen, Vibeke Binder, S. Halskov & Helga Flachs. (1982) 5-Aminosalicylic Acid in a Slow-Release Preparation: Bioavailability, Plasma Level, and Excretion in Humans. Gastroenterology 83:5, pages 1062-1070.
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J.F. Newton, C.-H. Kuo, M.W. Gemborys, G.H. Mudge & J.B. Hook. (1982) Nephrotoxicity of p-aminophenol, a metabolite of acetaminophen, in the Fischer 344 rat. Toxicology and Applied Pharmacology 65:2, pages 336-344.
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Michael BallsSteven Horner. (2020) Cell and Organ Cultures as Alternatives in Toxicity Testing. Alternatives to Laboratory Animals 10:1, pages 16-26.
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J. Chayen. (1982) Concerning the possibility of redox drugs. Agents and Actions 12:4, pages 530-535.
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Richard H. Clothier, Michael Balls, Gary S. Hostry, Neil J. Robertson & Steven A. Horner. (1982) Amphibian organ culture in experimental toxicology: The effects of paracetamol and phenacetin on cultured tissues from urodele and anuran amphibians. Toxicology 25:1, pages 31-40.
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Gilbert H. Mudge. 1982. Nephrotoxic Mechanisms of Drugs and Environmental Toxins. Nephrotoxic Mechanisms of Drugs and Environmental Toxins 209 225 .
Vernon L. Singleton. 1981. 149 242 .
A.S.Krishna Murthy, Agnes B. Russfield, Miasnig Hagopian, Ruth Monson, Jane Snell & Elizabeth K. Weisburger. (1979) Carcinogenicity and nephrotoxicity of 2-amino-, 1-amino- 2-methyl-, and 2-methyl-1-nitro-anthraquinone. Toxicology Letters 4:2, pages 71-78.
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R.G. Price. (1979) Studies on the nephrotoxicity of p-nitrophenylarsonic acid: Changes in rat kidney and urinary enzyme activities following the administration of p-nitrophenylarsonic acid. Chemico-Biological Interactions 24:2, pages 241-255.
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Robert P. Hanzlik, Kamlesh P. Vyas & George J. Traiger. (1978) Substituent effects on the hepatotoxicity of thiobenzamide derivatives in the rat. Toxicology and Applied Pharmacology 46:3, pages 685-694.
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Harald Gaber, Manfred Kiese & Gerhard Renner. (1977) Biotransformation and some effects of 2-dimethylamino-4-(N-methylanilino)-phenol in dogs. Naunyn-Schmiedeberg's Archives of Pharmacology 298:3, pages 217-222.
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Jerry R. Mitchell, Randolph J. McMurtry, Charles N. Statham & Sidney D. Nelson. (1977) Molecular basis for several drug-induced nephropathies. The American Journal of Medicine 62:4, pages 518-526.
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J.R. Mitchell. 1976. Mechanisms of Toxicity and Metabolism. Mechanisms of Toxicity and Metabolism 99 108 .
M. Kiese, L. Szinicz, N. Thiel & N. Weger. (1975) Ferrihemoglobin and kidney lesions in rats produced by 4-aminophenol or 4-dimethylaminophenol. Archives of Toxicology 34:4, pages 337-340.
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