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Xenobiotica
the fate of foreign compounds in biological systems
Volume 5, 1975 - Issue 4
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Research Article

Comparative Metabolic Study of Nimetazepam and its Desmethyl Derivative (Nitrazepam) in Rats

Yoshikazu Yanagi Pharmaceuticals Division, Sumitomo Chemical Co., Ltd., 4-2-1, Takatsukasa, Takarazuka, Hyogo, 665, Japan
,
Fumie Haga Pharmaceuticals Division, Sumitomo Chemical Co., Ltd., 4-2-1, Takatsukasa, Takarazuka, Hyogo, 665, Japan
,
Michio Endo Pharmaceuticals Division, Sumitomo Chemical Co., Ltd., 4-2-1, Takatsukasa, Takarazuka, Hyogo, 665, Japan
&
Sumio Kitagawa Pharmaceuticals Division, Sumitomo Chemical Co., Ltd., 4-2-1, Takatsukasa, Takarazuka, Hyogo, 665, Japan
Pages 245-257 | Received 05 Jun 1974, Published online: 22 Sep 2008

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Shiuan-Woei LinWu, Andrew H-J Wang & Fu-Chuo Peng. (2010) Flavin-containing reductase: new perspective on the detoxification of nitrobenzodiazepine. Expert Opinion on Drug Metabolism & Toxicology 6:8, pages 967-981.
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G. W. Elmer & R. P. Remmel. (1984) Role of the intestinal microflora in clonazepam metabolism in the rat. Xenobiotica 14:11, pages 829-840.
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H. P. A. Illing, M. A. Yeomaxs, P. A. Rising & P. Johnson. (1977) Enzymic Dealkylation of a Substituted Aminoacetamidobenzophenone and Cyclization to the Corresponding Benzodiazepine in vitro. Xenobiotica 7:7, pages 439-454.
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P. A. Rising, H. P. A. Illing, P. Johnson & M. A. Yeomans. (1977) The Metabolism of a Substituted Aminoacetamido-benzophenone and Cyclization to the Corresponding Benzodiazepine in the Rat in vivo. Xenobiotica 7:7, pages 425-437.
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Yoshikazu Yanagi, Fumie Haga, Michio Endo & Sumio Kitagawa. (1976) Comparative Metabolic Study of Nimetazepam and its Desmethyl Derivative (Nitrazepam) in Dogs. Xenobiotica 6:2, pages 101-112.
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Articles from other publishers (9)

Hei Hwa Lee, Jong Feng Lee, Sin Yu Lin, Yan Yin Lin, Chia Fang Wu, Ming Tsang Wu & Bai Hsiun Chen. (2013) Simultaneous quantification of urine flunitrazepam, nimetazepam and nitrazepam by using liquid chromatography tandem mass spectrometry. Clinica Chimica Acta 420, pages 134-139.
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D S Hewick & V Shaw. (1978) Tissue distribution of radioactivity after injection of [14C]nitrazepam in young and old rats. Journal of Pharmacy and Pharmacology 30:1, pages 318-319.
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Satoshi Takeno & Takeshi Sakai. (2005) Involvement of the intestinal microflora in nitrazepam‐induced teratogenicity in rats and its relationship to nitroreduction. Teratology 44:2, pages 209-214.
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Sylvia A. Wilson, Roger Tavendale & David S. Hewick. (1985) The biliary elimination of amaranth, indocyanine green and nitrazepam in germ-free rats. Biochemical Pharmacology 34:6, pages 857-863.
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N. Ya. Golovenko & M. Yu. Totrova. (1985) Strategy of the search for physiologically active substances according to their metabolites (survey). Pharmaceutical Chemistry Journal 19:3, pages 163-170.
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Iwao Nakatsuka, Hiroshi Shimizu, Yukio Asami, Terufumi Katoh, Akira Hirose & Akira Yoshitake. (1985) Benzodiazepines and their metabolites: Relationship between binding affinity to the benzodiazepine receptor and pharmacological activity. Life Sciences 36:2, pages 113-119.
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. (1978) PROCEEDINGS OF THE British Pharmacological Society. British Journal of Pharmacology 62:3, pages 373P-472P.
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Lauri Kangas. (1977) Comparison of two gas-liquid chromatographic methods for the determination of nitrazepam in plasma. Journal of Chromatography A 136:2, pages 259-270.
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W. Dieterle, J. W. Faigle, C. Montigel, M. Sulc & W. Theobald. (1977) Biotransformation and pharmacokinetics of acenocoumarol (Sintrom�) in man. European Journal of Clinical Pharmacology 11:5, pages 367-375.
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