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Xenobiotica
the fate of foreign compounds in biological systems
Volume 5, 1975 - Issue 3
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Research Article

The Metabolism of 3-Chloro-, 3-Bromo- and 3-Iodopropan-1,2-diol in Rats and Mice

Pages 155-165 | Received 01 Jul 1974, Published online: 22 Sep 2008

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C. Crews, A. Chiodini, M. Granvogl, C. Hamlet, K. Hrnčiřík, J. Kuhlmann, A. Lampen, G. Scholz, R. Weisshaar, T. Wenzl, P.R. Jasti & W. Seefelder. (2013) Analytical approaches for MCPD esters and glycidyl esters in food and biological samples: a review and future perspectives. Food Additives & Contaminants: Part A 30:1, pages 11-45.
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AminA. Nomeir, DeniseM. Silveira, NicholasF. Ferrala, PeterM. Markham, MadelineF. McComish, BurhanI. Ghanayem & Marjory Chadwick. (1995) Comparative disposition of 2,3‐epoxy‐1‐propanol (glycidol) in rats following oral and intravenous administration. Journal of Toxicology and Environmental Health 44:2, pages 203-217.
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M. J. Bartels & C. Timchalk. (1990) 1,2-Dichloropropane: investigation of the mechanism of mercapturic acid formation in the rat. Xenobiotica 20:10, pages 1035-1042.
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A. R. Jones & Jennifer Gibson. (1980) 1,2-Dichloropropane: metabolism and fate in the rat. Xenobiotica 10:11, pages 835-846.
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A. R. Jones & D. A. Walsh. (1980) The fate of S-propylcysteine in the rat. Xenobiotica 10:11, pages 827-834.
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A. R. Jones & R. W. O'brien. (1980) Metabolism of three active analogues of the male antifertility agent α-chlorohydrin in the rat. Xenobiotica 10:5, pages 365-370.
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A. R. Jones & D. A. Walsh. (1979) The Oxidative Metabolism of 1-Bromopropane in the Rat. Xenobiotica 9:12, pages 763-772.
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A. R. Jones & G. Fakhouri. (1979) Epoxides as Obligatory Intermediates in the Metabolism of α-Halohydrins. Xenobiotica 9:10, pages 595-599.
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A. R. Jones, P. M. Mashford & C. Murcott. (1979) The metabolism of 3-amino-1-chloropropan-2-ol in relation to its antifertility activity in male rats. Xenobiotica 9:4, pages 253-261.
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A. R. Jones, D. H. Milton & Carole Murcott. (1978) The Oxidative Metabolism of α-Chlorohydrin in the Male Rat and the Formation of Spermatocoeles. Xenobiotica 8:9, pages 573-582.
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Märeen J. Crawford, D. H. Hutson & Päline A. King. (1976) Metabolic Demethylation of the Insecticide Dimethyl-vinphos in Rats, in Dogs, and in vitro. Xenobiotica 6:12, pages 745-762.
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Andreas Eisenreich, Bernhard H. Monien, Mario E. Götz, Thorsten Buhrke, Axel Oberemm, Katharina Schultrich, Klaus Abraham, Albert Braeuning & Bernd Schäfer. (2023) 3-MCPD as contaminant in processed foods: State of knowledge and remaining challenges. Food Chemistry 403, pages 134332.
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Katharina Schultrich, Fulya Oez, Nick Bergau, Thorsten Buhrke & Albert Braeuning. (2021) Absorption and metabolism of 3-MCPD in hepatic and renal cell lines. Toxicology in Vitro 70, pages 105042.
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Nick Bergau, Zhiyong Zhao, Klaus Abraham & Bernhard H. Monien. (2021) Metabolites of 2‐ and 3‐Monochloropropanediol (2‐ and 3‐MCPD) in Humans: Urinary Excretion of 2‐Chlorohydracrylic Acid and 3‐Chlorolactic Acid after Controlled Exposure to a Single High Dose of Fatty Acid Esters of 2‐ and 3‐MCPD. Molecular Nutrition & Food Research 65:4, pages 2000736.
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Ryo Inagaki, Kohei Uchino, Yuko Shimamura & Shuichi Masuda. (2019) Investigation of DNA damage of glycidol and glycidol fatty acid esters using Fpg-modified comet assay. Fundamental Toxicological Sciences 6:1, pages 9-14.
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Ivonne M. C. M. Rietjens, P. Dussort, Helmut Günther, Paul Hanlon, Hiroshi Honda, Angela Mally, Sue O’Hagan, Gabriele Scholz, Albrecht Seidel, James Swenberg, Justin Teeguarden & Gerhard Eisenbrand. (2018) Exposure assessment of process-related contaminants in food by biomarker monitoring. Archives of Toxicology 92:1, pages 15-40.
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Jenny Aasa, Margareta Törnqvist & Lilianne Abramsson-Zetterberg. (2017) Measurement of micronuclei and internal dose in mice demonstrates that 3-monochloropropane-1,2-diol (3-MCPD) has no genotoxic potency in vivo. Food and Chemical Toxicology 109, pages 414-420.
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Jenny Aasa, Lilianne Abramsson-Zetterberg, Henrik Carlsson & Margareta Törnqvist. (2017) The genotoxic potency of glycidol established from micronucleus frequency and hemoglobin adduct levels in mice. Food and Chemical Toxicology 100, pages 168-174.
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Renata Kowalczyk, Paul W. R. Harris, Geoffrey M. Williams, Sung-Hyun Yang & Margaret A. Brimble. 2017. Peptides and Peptide-based Biomaterials and their Biomedical Applications. Peptides and Peptide-based Biomaterials and their Biomedical Applications 185 227 .
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Saeko Onami, Young-Man Cho, Takeshi Toyoda, Jun-ichi Akagi, Satoshi Fujiwara, Ryosuke Ochiai, Kazushige Tsujino, Akiyoshi Nishikawa & Kumiko Ogawa. (2015) Orally administered glycidol and its fatty acid esters as well as 3-MCPD fatty acid esters are metabolized to 3-MCPD in the F344 rat. Regulatory Toxicology and Pharmacology 73:3, pages 726-731.
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Bai Qin Lee & Sook Mei Khor. (2015) 3-Chloropropane-1,2-diol (3-MCPD) in Soy Sauce: A Review on the Formation, Reduction, and Detection of This Potential Carcinogen. Comprehensive Reviews in Food Science and Food Safety 14:1, pages 48-66.
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Elisabeth Eckert, Gabriele Leng, Wolfgang Gries & Thomas Göen. (2013) Excretion of mercapturic acids in human urine after occupational exposure to 2-chloroprene. Archives of Toxicology 87:6, pages 1095-1102.
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Naohiro Ikeda, Kenkichi Fujii, Miko Sarada, Hitoshi Saito, Masayoshi Kawabata, Kiyoko Naruse, Katsuyuki Yuki, Hideaki Nakagiri, Hiroshi Honda, Yasushi Tamaki, Naohiro Nishiyama & Toshio Kasamatsu. (2012) Genotoxicity studies of glycidol fatty acid ester (glycidol linoleate) and glycidol. Food and Chemical Toxicology 50:11, pages 3927-3933.
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Hiroshi Honda, Kenkichi Fujii, Tohru Yamaguchi, Naohiro Ikeda, Naohiro Nishiyama & Toshio Kasamatsu. (2012) Glycidol exposure evaluation of humans who have ingested diacylglycerol oil containing glycidol fatty acid esters using hemoglobin adducts. Food and Chemical Toxicology 50:11, pages 4163-4168.
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Elisabeth Eckert, Klaus Schmid, Barbara Schaller, Kerstin Hiddemann-Koca, Hans Drexler & Thomas Göen. (2011) Mercapturic acids as metabolites of alkylating substances in urine samples of German inhabitants. International Journal of Hygiene and Environmental Health 214:3, pages 196-204.
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Nadiya Bakhiya, Klaus Abraham, Rainer Gürtler, Klaus Erich Appel & Alfonso Lampen. (2011) Toxicological assessment of 3-chloropropane-1,2-diol and glycidol fatty acid esters in food. Molecular Nutrition & Food Research 55:4, pages 509-521.
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