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Xenobiotica
the fate of foreign compounds in biological systems
Volume 5, 1975 - Issue 7
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Research Article

Glutathione Conjugates as Metabolites of Benz[a]anthracene

G. R. Keysell Chester Beatty Research Institute, Institute of Cancer Research: Royal Cancer Hospital, Fulham Road, London, UK, SW3 6JB
,
J. Booth Chester Beatty Research Institute, Institute of Cancer Research: Royal Cancer Hospital, Fulham Road, London, UK, SW3 6JB
&
P. Sims Chester Beatty Research Institute, Institute of Cancer Research: Royal Cancer Hospital, Fulham Road, London, UK, SW3 6JB
Pages 439-448 | Received 03 Dec 1974, Published online: 22 Sep 2008

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Bernard Testa & Peter Jenner. (1978) Novel Drug Metabolites Produced by Functionalization Reactions: Chemistry and Toxicology. Drug Metabolism Reviews 7:2, pages 325-369.
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Articles from other publishers (15)

Peter A. Van Veld, John S. Patton & Richard F. Lee. (1988) Effect of preexposure to dietary benzo[a]pyrene (BP) on the first-pass metabolism of BP by the intestine of toadfish (Opsanus tau): in vivo studies using portal vein-catheterized fish. Toxicology and Applied Pharmacology 92:2, pages 255-265.
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NOBUO NEMOTO. 1981. Polycyclic Hydrocarbons and Cancer. Polycyclic Hydrocarbons and Cancer 213 258 .
PETER SIMS & PHILIP L. GROVER. 1981. Polycyclic Hydrocarbons and Cancer. Polycyclic Hydrocarbons and Cancer 117 181 .
F.F. Kadlubar, B. Ketterer, T.J. Flammang & Lucia Christodoulides. (1980) Formation of 3-(glutathion-S-yl)-N-methyl-4-aminoazobenzene and inhibition of aminoazo dye-nucleic acid binding in vitro by reaction of glutathione with metabolically-generated N-methyl-4-aminoazobenzene-N-sulfate. Chemico-Biological Interactions 31:3, pages 265-278.
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C.S. Cooper, A. Hewer, O. Ribeiro, P.L. Grover & P. Sims. (1980) The enzyme-catalysed conversion of a non-‘bay-region’ diol-epoxide of benz[a] anthracene into a glutathione conjugate. FEBS Letters 118:1, pages 39-42.
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Peter Sims. 1980. Carcinogenesis: Fundamental Mechanisms and Environmental Effects. Carcinogenesis: Fundamental Mechanisms and Environmental Effects 33 42 .
. (1979) Inhibition of rat liver glutathione S -transferase activity by aprotic solvents . FEBS Letters 101:1, pages 187-190.
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SHEN K. YANG, JOSEPH DEUTSCH & HARRY V. GELBOIN. 1978. Environment, Chemistry, and Metabolism. Environment, Chemistry, and Metabolism 205 231 .
D.M. JERINA, H. YAGI, R.E. LEHR, D.R. THAKKER, M. SCHAEFER-RIDDER, J.M. KARLE, W. LEVIN, A.W. WOOD, R.L. CHANG & A.H. CONNEY. 1978. Environment, Chemistry, and Metabolism. Environment, Chemistry, and Metabolism 173 188 .
H. Marquardt, S. Baker, B. Tierney, P. L. Grover & P. Sims. (2006) The metabolic activation of 7‐methylbenz(a)anthracene: The induction of malignant transformation and mutation in mammalian cells by non‐K‐region dihydrodiols. International Journal of Cancer 19:6, pages 828-833.
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Antonia Flaks & Peter Sims. (1977) The activity of 7-methylbenz(a)anthracene metabolites in an in vitro-in vivo carcinogenicity test using mouse lung tissue. Cancer Letters 3, pages 163-167.
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Leila Diamond & William M. Baird. 1977. Growth, Nutrition, and Metabolism of Cells in Culture. Growth, Nutrition, and Metabolism of Cells in Culture 421 470 .
Peter Sims. 1977. Biological Reactive Intermediates. Biological Reactive Intermediates 358 370 .
P. L. Grover, A. Hewer, K. Pal & P. Sims. (2006) The involvement of a diol‐epoxide in the metabolic activation of benzo( a )pyrene in human bronchial mucosa and in mouse skin . International Journal of Cancer 18:1, pages 1-6.
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Joan Booth & Peter Sims. (1976) Different pathways involved in the metabolism of the 7.8- and 9, 10-dihydrodiols of benzo(a)pyrene. Biochemical Pharmacology 25:8, pages 979-980.
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