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Xenobiotica
the fate of foreign compounds in biological systems
Volume 5, 1975 - Issue 8
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Research Article

Enzymic N-Acetylation of 2,4-Toluenediamine by Liver Cytosols from Various Species

Thirayudh Glinsukon Carcinogen Metabolism and Toxicology Branch, National Cancer Institute, Bethesda, Maryland, 20014, USA; Carcinogen Metabolism and Toxicology Branch, National Cancer Institute, Physiology Department, Faculty of Science, Rama 6th Rd., Bangkok, Thailand
,
Timothy Benjamin Carcinogen Metabolism and Toxicology Branch, National Cancer Institute, Bethesda, Maryland, 20014, USA
,
Preston H. Grantham Carcinogen Metabolism and Toxicology Branch, National Cancer Institute, Bethesda, Maryland, 20014, USA
,
Elizabeth K. Weisburger Carcinogen Metabolism and Toxicology Branch, National Cancer Institute, Bethesda, Maryland, 20014, USA
&
Peter P. Roller Carcinogen Metabolism and Toxicology Branch, National Cancer Institute, Bethesda, Maryland, 20014, USA
Pages 475-483 | Received 02 Jan 1975, Published online: 14 Oct 2008

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A. I. Loureiro & P. Soares-da-Silva. (2015) Distribution and pharmacokinetics of etamicastat and its N-acetylated metabolite (BIA 5-961) in dog and monkey. Xenobiotica 45:10, pages 903-911.
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ElizabethK. Weisburger. (1996) 1986 Herbert Stokinger Lecture Family Ties: Scientific Ancestors and Scientific Associations. Applied Occupational and Environmental Hygiene 11:10, pages 1195-1197.
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L. A. Bums, S. G. Bradley, K. L. White, J. A. McCay, B. A. Fuchs, M. Stern, R. D. Brown, D. L. Musgrove, M. P. Holsapple, M. I. Luster & A. E. Munson. (1994) Immunotoxicity of 2,4-Diaminotoluene in Female B6C3F1 Mice. Drug and Chemical Toxicology 17:3, pages 401-436.
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M. K. Baldwin & D. H. Hutson. (1980) The metabolism of 3-chloro-4-fluoro-aniline in dog and rat. Xenobiotica 10:2, pages 135-144.
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PeterD. Unger, AnthonyJ. Salerno, WilliamC. Ness & MarvinA. Friedman. (1980) Tissue distribution and excretion of 2,4‐[14C] toluenediamine in the mouse. Journal of Toxicology and Environmental Health 6:1, pages 107-114.
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R. H. Waring & A. E. Pheasant. (1976) Some Phenolic Metabolites of 2, 4-Diaminotoluene in the Rabbit, Rat and Guinea-pig. Xenobiotica 6:4, pages 257-262.
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Lisa Grohmann, Daniel Becker, Jörg Rademann, Nan Ma, Monika Schäfer-Korting & Günther Weindl. (2017) Biotransformation of 2,4-toluenediamine in human skin and reconstructed tissues. Archives of Toxicology 91:10, pages 3307-3316.
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Nuno Miguel Pires, Ana Isabel Loureiro, Bruno Igreja, Pierre Lacroix & Patrício Soares-da-Silva. (2015) Cardiovascular safety pharmacology profile of etamicastat, a novel peripheral selective dopamine-ß-hydroxylase inhibitor. European Journal of Pharmacology 750, pages 98-107.
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Ana I. Loureiro, Carlos Fernandes-Lopes, Maria João Bonifácio, Lyndon C. Wright & Patrício Soares-da-Silva. (2013) N -Acetylation of Etamicastat, a Reversible Dopamine- β -Hydroxylase Inhibitor . Drug Metabolism and Disposition 41:12, pages 2081-2086.
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Michio Sayama, Takashi Kondo & Masa-aki Mori. (2002) Cytosolic Acetyl Transfer and N-Deacetylation Associated with the Metabolism of Carcinogenic 2,4-Diaminotoluene in Rat Liver.. Journal of Health Science 48:6, pages 485-492.
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Lauren A. Trepanier, Kunal Ray, Nena J. Winand, Stephen P. Spielberg & Alastair E. Cribb. (1997) Cytosolic arylamine n-acetyltransferase (NAT) deficiency in the dog and other canids due to an absence of NAT genes. Biochemical Pharmacology 54:1, pages 73-80.
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D.L. Freedman, R.S. Shanley & R.J. Scholze. (1996) Aerobic biodegradation of 2,4-dinitrotoluene, aminonitrotoluene isomers, and 2,4-diaminotoluene. Journal of Hazardous Materials 49:1, pages 1-14.
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Michael J. Bartels, Charles Timchalk & Fred. A. Smith. (1993) Gas chromatographic/tandem mass spectrometric identification and quantitation of metabolic 4-acetyltoluene-2,4-diamine from the F344 rat. Biological Mass Spectrometry 22:3, pages 194-200.
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Gunnar Skarping, Torhj�rn Brorson & Carsten Sang�. (1991) Biological monitoring of isocyanates and related amines. International Archives of Occupational and Environmental Health 63:2, pages 83-88.
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Douglas E. Rickert, James A. Bond, Rochelle M. Long & John P. Chism. (1983) Metabolism and excretion of nitrobenzene by rats and mice. Toxicology and Applied Pharmacology 67:2, pages 206-214.
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A. De Pascale, L. Cobelli, R. Paladino, L. Pastorello, A. Frigerio & C. Sala. (1983) Quantitative determination of airborne 2,4-toluene diisocyanate. Journal of Chromatography A 256, pages 352-358.
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C. V. Eadsforth. 1983. Drug Metabolite Isolation and Determination. Drug Metabolite Isolation and Determination 119 133 .
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Thirayudh Glinsukon, Auranuch Lookyee, Chaivat Toskulkao & Ronald C. Shank. (1980) N-Deacetylase activity in subcellular fractions of mouse liver. Biochemical Pharmacology 29:8, pages 1189-1191.
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Peter D. Unger & Marvin A. Friedman. (1979) High-performance liquid chromatography of 2,6- and 2,4-diaminotoluene, and its application to the determination of 2,4-diaminotoluene in urine and plasma. Journal of Chromatography A 174:2, pages 379-384.
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Tore Aune, Sidney D. Nelson & Erik Dybing. (1979) Mutagenicity and irreversible binding of the hepatocarcinogen, 2,4-diaminotoluene. Chemico-Biological Interactions 25:1, pages 23-33.
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Jane B. Idoine, Jerry M. Elliott, Mary J. Wilson & Elizabeth K. Weisburger. (1976) Ratliver cells in culture: Effect of storage, long-term culture, and transformation on some enzyme levels. In Vitro 12:8, pages 541-553.
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