Citations (79)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (8)
Timothy R. Fennell, James M. Mathews, Rodney W. Snyder, Yan Hong, Scott L. Watson, Sherry R. Black, Barry S. McIntyre & Suramya Waidyanatha. (2018) Metabolism and disposition of 2-ethylhexyl-p-methoxycinnamate following oral gavage and dermal exposure in Harlan Sprague Dawley rats and B6C3F1/N mice and in hepatocytes in vitro. Xenobiotica 48:11, pages 1142-1156.
Read now
Read now
J. C. ENGLISH, P. J. DEISINGER & D. GUEST. (1998) Metabolism of 2-ethylhexanoic acid administered orally or dermally to the female Fischer 344 rat1. Xenobiotica 28:7, pages 699-714.
Read now
Read now
E. D. Barber, J. A. Fox & C. J. Giordano. (1994) Hydrolysis, absorption and metabolism of di(2-ethylhexyl) terephthalate in the rat. Xenobiotica 24:5, pages 441-450.
Read now
Read now
P. J. Deisinger, R. J. Boatman & D. Guest. (1994) Metabolism of 2-ethylhexanol administered orally and dermally to the female Fischer 344 rat. Xenobiotica 24:5, pages 429-440.
Read now
Read now
Phillip W. Albro & Steven R. Lavenhar. (1989) Metabolism of DI(2=Ethylhexyl)Phthalate. Drug Metabolism Reviews 21:1, pages 13-34.
Read now
Read now
P. Schmid & Ch. Schlatter. (1985) Excretion and metabolism of di(2-ethylhexyl)-phthalate in man. Xenobiotica 15:3, pages 251-256.
Read now
Read now
P. W. Albro, Jean T. Corbett, D. Marbury & Carol Parker. (1984) Urinary metabolites of orally administered di-(5-hexenyl) phthalate and di-(9-decenyl) phthalate in the rat. Xenobiotica 14:5, pages 389-398.
Read now
Read now
S. Northup, L. Martis, R. Ulbricht, J. Garber, J. Miripol & T. Schmitz. (1982) Comment on the carcinogenic potential of Di(2‐ethylhexyl) phthalate. Journal of Toxicology and Environmental Health 10:3, pages 493-518.
Read now
Read now
Articles from other publishers (71)
Yu-Ning Hu, Jin-Tao Zhan, Pei-Rong Bai, Na An, Jun-Jie Tan, Yan-Zhen Wang, Quan-Fei Zhu & Yu-Qi Feng. (2023) In-depth profiling of di(2-ethylhexyl) phthalate metabolic footprints in rats using click chemistry-mass spectrometry probes. Journal of Hazardous Materials 452, pages 131190.
Crossref
Crossref
David Hala, Lene H. Petersen, Duane B. Huggett, Michelle A. Puchowicz, Henri Brunengraber & Guo-Fang Zhang. (2021) Overcompensation of CoA Trapping by Di(2-ethylhexyl) Phthalate (DEHP) Metabolites in Livers of Wistar Rats. International Journal of Molecular Sciences 22:24, pages 13489.
Crossref
Crossref
Alexandra Nehring, Daniel Bury, Benedikt Ringbeck, Hans-Willi Kling, Rainer Otter, Tobias Weiss, Thomas Brüning & Holger M. Koch. (2020) Metabolism and urinary excretion kinetics of di(2-ethylhexyl) adipate (DEHA) in four human volunteers after a single oral dose. Toxicology Letters 321, pages 95-102.
Crossref
Crossref
Takanari Wakayama, Yuki Ito, Kiyoshi Sakai, Mio Miyake, Eiji Shibata, Hiroyuki Ohno & Michihiro Kamijima. (2019) Comprehensive review of 2‐ethyl‐1‐hexanol as an indoor air pollutant. Journal of Occupational Health 61:1, pages 19-35.
Crossref
Crossref
Terry W. Schultz, Katarzyna R. Przybylak, Andrea-Nicole Richarz, Claire L. Mellor, Steven P. Bradbury & Mark T.D. Cronin. (2017) Read-across of 90-day rat oral repeated-dose toxicity: A case study for selected 2-alkyl-1-alkanols. Computational Toxicology 2, pages 28-38.
Crossref
Crossref
A.M. Api, D. Belsito, S. Bhatia, M. Bruze, P. Calow, M.L. Dagli, W. Dekant, A.D. Fryer, L. Kromidas, S. La Cava, J.F. Lalko, A. Lapczynski, D.C. Liebler, Y. Miyachi, V.T. Politano, G. Ritacco, D. Salvito, T.W. Schultz, J. Shen, I.G. Sipes, B. Wall & D.K. Wilcox. (2016) RIFM fragrance ingredient safety assessment, 2-ethyl-1-butanol, CAS Registry Number 97-95-0. Food and Chemical Toxicology 97, pages S157-S167.
Crossref
Crossref
A.M. Api, D. Belsito, S. Bhatia, M. Bruze, P. Calow, M.L. Dagli, W. Dekant, A.D. Fryer, L. Kromidas, S. La Cava, J.F. Lalko, A. Lapczynski, D.C. Liebler, T.M. Penning, V.T. Politano, G. Ritacco, D. Salvito, T.W. Schultz, J. Shen, I.G. Sipes, B. Wall & D.K. Wilcox. (2016) RIFM fragrance ingredient safety assessment, 2-ethyl-1-hexanol, CAS registry number 104-76-7. Food and Chemical Toxicology 97, pages S147-S156.
Crossref
Crossref
A.M. Api, D. Belsito, S. Bhatia, M. Bruze, P. Calow, M.L. Dagli, W. Dekant, A.D. Fryer, L. Kromidas, S. La Cava, J.F. Lalko, A. Lapczynski, D.C. Liebler, T.M. Penning, V.T. Politano, G. Ritacco, D. Salvito, T.W. Schultz, J. Shen, I.G. Sipes, B. Wall & D.K. Wilcox. (2016) RIFM fragrance ingredient safety assessment, 2-methylundecanol, CAS Registry Number 10522-26-6. Food and Chemical Toxicology 97, pages S119-S128.
Crossref
Crossref
. (2013) Scientific Opinion on Flavouring Group Evaluation 06, Revision 4 (FGE.06Rev4): Straight‐ and branched‐chain aliphatic unsaturated primary alcohols, aldehydes, carboxylic acids and esters from chemical groups 1, 3 and 4. EFSA Journal 11:2.
Crossref
Crossref
Helmut Bahrmann, Heinz‐Dieter Hahn, Dieter Mayer & Guido D. Frey. 2003. Ullmann's Encyclopedia of Industrial Chemistry. Ullmann's Encyclopedia of Industrial Chemistry.
Chris Bevan. 2003. Patty's Toxicology. Patty's Toxicology
1
54
.
. (2012) Scientific Opinion on Flavouring Group Evaluation 10, Revision 3 (FGE.10Rev3): Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30. EFSA Journal 10:3.
Crossref
Crossref
. (2011) Scientific Opinion on Flavouring Group Evaluation 06, Revision 3 (FGE.06Rev3): Straight‐ and branched‐chain aliphatic unsaturated primary alcohols, aldehydes, carboxylic acids, and esters from chemical groups 1 and 4. EFSA Journal 9:11.
Crossref
Crossref
Helmut Bahrmann, Heinz-Dieter Hahn & Dieter Mayer. 2000. Ullmann's Encyclopedia of Industrial Chemistry. Ullmann's Encyclopedia of Industrial Chemistry.
. (2011) Scientific Opinion on Flavouring Group Evaluation 10, Revision 2 (FGE.10Rev2): Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30. EFSA Journal 9:7.
Crossref
Crossref
. (2011) Scientific Opinion on Flavouring Group Evaluation 06, Revision 2 (FGE.06Rev2): Straight‐ and branched‐chain aliphatic unsaturated primary alcohols, aldehydes, carboxylic acids, and esters from chemical groups 1 and 4. EFSA Journal 9:3.
Crossref
Crossref
. (2010) Flavouring Group Evaluation 01 Rev2 (FGE.01 Rev2): Branched-chain aliphatic saturated aldehydes, carboxylic acids and related esters of primary alcohols and branched-chain carboxylic acids from chemical groups 1 and 2. EFSA Journal 8:11, pages 1843.
Crossref
Crossref
. (2010) Flavouring Group Evaluation 5, Revision 2 (FGE.05Rev2): Branched- and straight-chain unsaturated carboxylic acids and esters of these with aliphatic saturated alcohols from chemical groups 1, 2, 3 and 5. EFSA Journal 8:10, pages 1400.
Crossref
Crossref
D. Belsito, D. Bickers, M. Bruze, P. Calow, H. Greim, J.M. Hanifin, A.E. Rogers, J.H. Saurat, I.G. Sipes & H. Tagami. (2010) A safety assessment of branched chain saturated alcohols when used as fragrance ingredients. Food and Chemical Toxicology 48, pages S1-S46.
Crossref
Crossref
D. McGinty, J. Scognamiglio, C.S. Letizia & A.M. Api. (2010) Fragrance material review on 2-ethyl-1-hexanol. Food and Chemical Toxicology 48, pages S115-S129.
Crossref
Crossref
. (2009) Flavouring Group Evaluation 10, Revision 1 (FGE10 Rev1) - Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical g. EFSA Journal 7:1, pages 934.
Crossref
Crossref
. (2009) Flavouring Group Evaluation 04 −2-Ethylhexyl derivatives from chemical group 2 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC). EFSA Journal 7:1, pages 929.
Crossref
Crossref
Takashi Yamada, Duk-Young Jung, Rumi Sawada & Toshie Tsuchiya. (2008) Intracerebral microinjection of stannous 2-ethylhexanoate affects dopamine turnover in cerebral cortex and locomotor activity in rats. Journal of Biomedical Materials Research Part B: Applied Biomaterials 87B:2, pages 381-386.
Crossref
Crossref
. (2008) Flavouring Group Evaluation 2, Revision 1 (FGE.02) : Branched- and straight-chain aliphatic saturated primary alcohols and related esters of primary alcohols and straight-chain carboxylic acids and one straight-chain aldehyde from chemical groups 1 and 2. EFSA Journal 6:5, pages 709.
Crossref
Crossref
. (2008) Flavouring Group Evaluation 6, Revision 1 (FGE.06Rev1) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC). EFSA Journal 6:5, pages 616.
Crossref
Crossref
. (2008) Flavouring Group Evaluation 5, Revision 1 (FGE.05Rev1):Esters of branched‐ and straight‐chain aliphatic saturated primary alcohols and of one secondary alcohol, and branched‐ and straight‐chain unsaturated carboxylic acids from chemical groups 1, 2, and 5 (Commission Regulation (EC) No 1565/2000 of 18 July 2000) ‐ Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC). EFSA Journal 6:3.
Crossref
Crossref
Dana Stingel, Peter Feldmeier, Elke Richling, Michael Kempf, Sandra Elss, Samira Labib & Peter Schreier. (2007) Urinary 2‐ethyl‐3‐oxohexanoic acid as major metabolite of orally administered 2‐ethylhexanoic acid in human. Molecular Nutrition & Food Research 51:3, pages 301-306.
Crossref
Crossref
. (2005) Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) on a request from the Commission related to - Flavouring Group Evaluation 10: Aliphatic primary and secondary saturated and unsaturate. EFSA Journal 3:12, pages 246.
Crossref
Crossref
. (2005) Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Flavouring Group Evaluation 5 (FGE.05); Esters of 23 branched- and straight-chain aliphatic saturated primary alcohols and. EFSA Journal 3:7, pages 204.
Crossref
Crossref
Paula J. Lapinskas, Sherri Brown, Lisa M. Leesnitzer, Steven Blanchard, Cyndi Swanson, Russell C. Cattley & J. Christopher Corton. (2005) Role of PPARα in mediating the effects of phthalates and metabolites in the liver. Toxicology 207:1, pages 149-163.
Crossref
Crossref
. (2004) Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Flavouring Group Evaluation 6 (FGE.06): Straight-and branched-chain aliphatic unsatured primary alcohols, aldehydes, carbox. EFSA Journal 2:11, pages 108.
Crossref
Crossref
H. G. Wahl, Q. Hong, S. Hildenbrand, T. Risler, D. Luft & H. Liebich. (2004) 4-Heptanone is a metabolite of the plasticizer di(2-ethylhexyl) phthalate (DEHP) in haemodialysis patients. Nephrology Dialysis Transplantation 19:10, pages 2576-2583.
Crossref
Crossref
Robert Kavlock, Kim Boekelheide, Robert Chapin, Michael Cunningham, Elaine Faustman, Paul Foster, Mari Golub, Rogene Henderson, Irwin Hinberg, Ruth Little, Jennifer Seed, Katherine Shea, Sonia Tabacova, Rochelle Tyl, Paige Williams & Timothy Zacharewski. (2002) NTP Center for the Evaluation of Risks to Human Reproduction: phthalates expert panel report on the reproductive and developmental toxicity of di(2-ethylhexyl) phthalate. Reproductive Toxicology 16:5, pages 529-653.
Crossref
Crossref
Hans Günther Wahl, Qunfa Hong, Dolores Stübe, Martin E Maier, Hans-Ulrich Häring & Hartmut M Liebich. (2001) Simultaneous analysis of the di(2-ethylhexyl)phthalate metabolites 2-ethylhexanoic acid, 2-ethyl-3-hydroxyhexanoic acid and 2-ethyl-3-oxohexanoic acid in urine by gas chromatography–mass spectrometry. Journal of Chromatography B: Biomedical Sciences and Applications 758:2, pages 213-219.
Crossref
Crossref
C. Bevan Ph.D. 2003. Patty's Toxicology. Patty's Toxicology.
Valerie Walker & Graham A Mills. (2001) Urine 4-heptanone: a β-oxidation product of 2-ethylhexanoic acid from plasticisers. Clinica Chimica Acta 306:1-2, pages 51-61.
Crossref
Crossref
Sirpa M.A Pennanen, Kaisa M Heiskanen, Kai M Savolainen & Hannu Komulainen. (2000) Effects of 2-ethylhexanoic acid on the production of reactive oxygen species in human polymorphonuclear leukocytes in vitro. Toxicology Letters 117:1-2, pages 79-84.
Crossref
Crossref
Helmut Bahrmann & Hanswilhelm Bach. 2000. Ullmann's Encyclopedia of Industrial Chemistry. Ullmann's Encyclopedia of Industrial Chemistry.
W. Aulmann, W. Pittermann, F. Bartnik, W. Sterzel, W. K?stner & M. Potokar. (2000) Developmental toxicity of 2-ethylhexyl stearate. Food and Chemical Toxicology 38:1, pages 57-63.
Crossref
Crossref
Eugene D Barber, Karen R Miller, Marcy I Banton & M Vijayaraj Reddy. (1999) The lack of binding of methyl-n-amyl ketone (MAK) to rat liver DNA as demonstrated by direct binding measurements, and -postlabeling techniques. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 442:2, pages 133-147.
Crossref
Crossref
Klaus-Peter Rothenbacher, Reiner Kimmel, Sibylle Hildenbrand, Friedrich W Schmahl & Peter C Dartsch. (2016) Nephrotoxic effects of di-(2-ethylhexyl)phthalate (DEHP) hydrolysis products on cultured kidney epithelial cells. Human & Experimental Toxicology 17:6, pages 336-342.
Crossref
Crossref
D.R. Juberg, R.M. David, G.V. Katz, L.G. Bernard, D.R. Gordon, M.S. Vlaovic & D.C. Topping. (1998) 2-Ethylhexanoic Acid: Subchronic Oral Toxicity Studies in the Rat and Mouse. Food and Chemical Toxicology 36:5, pages 429-436.
Crossref
Crossref
T.B. Adams, D.B. Greer, J. Doull, I.C. Munro, P. Newberne, P.S. Portoghese, R.L. Smith, B.M. Wagner, C.S. Weil, L.A. Woods & R.A. Ford. (1998) The FEMA GRAS Assessment of Lactones Used as Flavour Ingredients. Food and Chemical Toxicology 36:4, pages 249-278.
Crossref
Crossref
H.-J. Klimisch, K. Deckardt, C. Gembardt & B. Hildebrand. (1998) Subchronic inhalation toxicity study of 2-ethylhexanol vapour in rats. Food and Chemical Toxicology 36:3, pages 165-168.
Crossref
Crossref
Brian G Lake, Roger J Price, Morag E Cunninghame & David G Walters. (1997) Comparison of the effects of di-(2-ethylhexyl)adipate on hepatic peroxisome proliferation and cell replication in the rat and mouse1Presented in part at the Annual Meeting of the Society of Toxicology, Dallas, Texas, March 13–17, 1994.1. Toxicology 123:3, pages 217-226.
Crossref
Crossref
S. Pennanen, A. Kojo, M. Pasanen, J. Liesivuori, RO Juvonen & H. Komulainen. (2016) CYP enzymes catalyze the formation of a terminal olefin from 2-ethylhexanoic acid in rat and human liver. Human & Experimental Toxicology 15:5, pages 435-442.
Crossref
Crossref
Lloyd D. Winberg & Mostafa Z. Badr. (1995) Mechanism of phthalate-induced inhibition of hepatic mitochondrial β-oxidation. Toxicology Letters 76:1, pages 63-69.
Crossref
Crossref
S.L. Plonait, H. Nau, R.F. Maier, W. Wittfoht & M. Obladen. (2003) Exposure of newborn infants to di‐(2‐ethylhexyl)‐phthalate and 2‐ ethylhexanoic acid following exchange transfusion with polyvinylchloride catheters. Transfusion 33:7, pages 598-605.
Crossref
Crossref
Richard B Moore. (2006) Preparation of di‐(2‐ethylhexyl) adipate and some of its metabolites labelled with deuterium. Journal of Labelled Compounds and Radiopharmaceuticals 31:10, pages 821-828.
Crossref
Crossref
M.C. Cornu, J.C. Lhuguenot, A.M. Brady, R. Moore & C.R. Elcombe. (1992) Identification of the proximate peroxisome proliferator(S) derived from DI (2-ethylhexyl) adipate and species differences in response. Biochemical Pharmacology 43:10, pages 2129-2134.
Crossref
Crossref
Y. Keith, M. C. Cornu, P. M. Canning, J. Foster, J. C. Lhuguenot & C. R. Elcombe. (1992) Peroxisome proliferation due to di (2-ethylhexyl) adipate, 2-ethylhexanol and 2-ethylhexanoic acid. Archives of Toxicology 66:5, pages 321-326.
Crossref
Crossref
S. Pennanen, S. Auriola, A. Manninen & H. Komulainen. (1991) Identification of the main metabolites of 2-ethylhexanoic acid in rat urine using gas chromatography—mass spectrometry. Journal of Chromatography B: Biomedical Sciences and Applications 568:1, pages 125-134.
Crossref
Crossref
Mostafa Z. Badr, Jeffrey A. Handler, Michael Whittaker, Frederick C. Kauffman & Ronald G. Thurman. (1990) Interactions between plasticizers and fatty acid metabolism in the perfused rat liver and in vivo. Biochemical Pharmacology 39:4, pages 715-721.
Crossref
Crossref
Tadeusz Górski, Thomas J. Goehl, C.W. Jameson, Bradley J. Collins, Joan Bursey & Robert Moseman. (1990) Gas chromatographic determination of 2-ethylhexanol and 2-ethylhexanoic acid as derivatives suitable for electroncapture and nitrogen-phosphorus detection after single reaction with heptafluorobutyrylimidazole. Journal of Chromatography A 509:2, pages 383-389.
Crossref
Crossref
. 1990. Toxicological Evaluations. Toxicological Evaluations
181
205
.
Y. Keith, M. C. Cornu, C. R. Elcombe & J. C. Lhuguenot. 1988. The Target Organ and the Toxic Process. The Target Organ and the Toxic Process
274
277
.
M. C. Cornu, Y. Keith, C. R. Elcombe & J. C. Lhuguenot. 1988. The Target Organ and the Toxic Process. The Target Organ and the Toxic Process
265
268
.
K. Bergman & L. Albanus. (1987) Di-(2-ethylhexyl) adipate: Absorption, autoradiographic distribution and elimination in mice and rats. Food and Chemical Toxicology 25:4, pages 309-316.
Crossref
Crossref
P W Albro. (1986) Absorption, metabolism, and excretion of di(2-ethylhexyl) phthalate by rats and mice.. Environmental Health Perspectives 65, pages 293-298.
Crossref
Crossref
P. Sjöberg, U. Bondesson, T. J. B. Gray & L. Plöen. (2009)
Effects of Di‐(2‐ethylhexyl) Phthalate and Five of its Metabolites on Rat Testis
in Vivo
and in
in Vitro
. Acta Pharmacologica et Toxicologica 58:3, pages 225-233.
Crossref
Crossref
G.D. Divincenzo, M.L. Hamilton, K.R. Mueller, W.H. Donish & E.D. Barber. (1985) Bacterial mutagenicity testing of urine from rats dosed with 2-ethylhexanol derived plasticizers. Toxicology 34:3, pages 247-259.
Crossref
Crossref
Phillip W. Albro, J.T. Corbett & J.L. Schroeder. (1984) Metabolism of methyl n-amyl ketone (2-heptanone) and its binding to DNA of rat liver in vivo and in vitro. Chemico-Biological Interactions 51:3, pages 295-308.
Crossref
Crossref
Phillip W. Albro, Ives Tondeur, Dean Marbury, Sandra Jordan, Joanna Schroeder & Jean T. Corbett. (1983) Polar metabolites of Di-(2-ethylhexyl)phthalate in the rat. Biochimica et Biophysica Acta (BBA) - General Subjects 760:2, pages 283-292.
Crossref
Crossref
Phillip W. Albro, Jean T. Corbett, Joanna L. Schroeder & Sandra T. Jordan. (1983) Incorporation of radioactivity from labeled di-(2-ethylhexyl)phthalate into DNA of rat liver in vivo. Chemico-Biological Interactions 44:1-2, pages 1-16.
Crossref
Crossref
Frank P. Bell. (1983) Effect of the plasticizer di(2-ethylhexyl) adipate (dioctyladipate, DOA) on lipid metabolism in the rat: I. Inhibition of cholesterolgenesis and modification of phospholipid synthesis. Lipids 18:3, pages 211-215.
Crossref
Crossref
Deepak K. Agarwal, Sarita Agarwal & Prahlad K. Seth. (1982) Interaction of di-(2-ethylhexyl) phthalate with the pharmacological response and metabolic aspects of ethanol in mice. Biochemical Pharmacology 31:21, pages 3419-3423.
Crossref
Crossref
Beverley A. Mangham, John R. Foster & Brian G. Lake. (1981) Comparison of the hepatic and testicular effects of orally administered Di(2-ethylhexyl) phthalate and dialkyl 79 phthalate in the rat. Toxicology and Applied Pharmacology 61:2, pages 205-214.
Crossref
Crossref
Terue Takahashi, Akira Tanaka & Tsutomu Yamaha. (1981) Elimination, distribution and metabolism of di-(2-ethylhexyl)adipate (deha) in rats. Toxicology 22:3, pages 223-233.
Crossref
Crossref
. (1979) 2-Ethylhexanol. Food and Cosmetics Toxicology 17, pages 775-777.
Crossref
Crossref
Göran Dave & Ulf Lidman. (1978) Biological and toxicological effects of solvent extraction chemicals. Hydrometallurgy 3:3, pages 201-216.
Crossref
Crossref
R.W.R. Baker. (1978) Diethylhexyl phthalate as a factor in blood tranfusion and haemodialysis. Toxicology 9:4, pages 319-329.
Crossref
Crossref