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Xenobiotica
the fate of foreign compounds in biological systems
Volume 5, 1975 - Issue 11
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Research Article

Microsomal N-Hydroxylation of Dibenzylamine

A. H. Beckett Department of Pharmacy, Chelsea College (University of London), Manresa Road, London, UK, SW3 6LX
&
G. G. Gibson Department of Pharmacy, Chelsea College (University of London), Manresa Road, London, UK, SW3 6LX
Pages 677-686 | Received 05 May 1975, Published online: 22 Sep 2008

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Peter Hlavica. (2002) N-OXIDATIVE TRANSFORMATION OF FREE AND N-SUBSTITUTED AMINE FUNCTIONS BY CYTOCHROME P450 AS MEANS OF BIOACTIVATION AND DETOXICATION. Drug Metabolism Reviews 34:3, pages 451-477.
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Peter Hlavica. (1994) Regulatory Mechanisms in the Activation of Nitrogenous Compounds by Mammalian Cytochrome P-450 Isozymes. Drug Metabolism Reviews 26:1-2, pages 325-348.
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Peter Hlavica & John W. Gorrod. (1982) Biological Oxidation of Nitrogen in Organic Compounds and Disposition of N-Oxidized Product. Critical Reviews in Biochemistry 12:1, pages 39-101.
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A. H. Beckett & K. Haya. (1978) The Stereoselective Metabolism of Ethylamphetamine with Fortified Rabbit Liver Homogenates. Xenobiotica 8:2, pages 85-96.
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Arnold H. Beckett & G. Gordon Gibson. (1978) Stereochemistry of the Metabolic Incorporation of Oxygen into (+)- and (-)-N-Benzylamphetamine. Xenobiotica 8:2, pages 73-83.
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R. T. Coutts & A. H. Beckett. (1977) Metabolic N-Oxidation of Primary and Secondary Aliphatic Medicinal Amines. Drug Metabolism Reviews 6:1, pages 51-104.
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H. P. A. Illing, M. A. Yeomaxs, P. A. Rising & P. Johnson. (1977) Enzymic Dealkylation of a Substituted Aminoacetamidobenzophenone and Cyclization to the Corresponding Benzodiazepine in vitro. Xenobiotica 7:7, pages 439-454.
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Shayne Cox Gad & Dexter SullivanJr.Jr.. 2023. Drug Safety Evaluation. Drug Safety Evaluation 293 330 .
Shayne Gad, Charlie Clifford & Dawn Goodman. 2015. Animal Models in Toxicology, Third Edition. Animal Models in Toxicology, Third Edition 21 151 .
A H Beckett & G G Gibson. (1977) Identification of the in vitro N -oxidized metabolites of (+)- and (−)- N -benzylamphetamine . Journal of Pharmacy and Pharmacology 29:1, pages 756-760.
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A H Beckett & G R Jones. (1977) Metabolic oxidation of aralkyl oximes to nitro compounds by fortified 9000 g liver supernatants from various species . Journal of Pharmacy and Pharmacology 29:1, pages 416-421.
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Peter Hlavica & Michael Lehnerer. (2006) Some aspects of the role of cytochrome P‐450 isozymes in the n‐oxidative transformation of secondary and tertiary amine compounds. Journal of Biochemical Toxicology 10:5, pages 275-285.
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M. B. Calvo, J. L. Pedraz & A. Dominguez‐Gil. (2006) Pharmacokinetics of dibenzylamine administered in a sustained drug delivery system with cefazolin. Biopharmaceutics & Drug Disposition 11:9, pages 797-806.
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B. Clement. (1989) STRUCTURAL REQUIREMENTS OF MICROSOMAL N-OXYGENATIONS DERIVED FROM STUDIES ON AMIDINES. Drug Metabolism and Drug Interactions 7:1.
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Antonio Morandi, Pierluigi Gambetti, Pramod K. Arora & Lawrence M. Sayre. (1987) Mechanism of neurotoxic action of β,β′-iminodipropionitrile (IDPN): N-hydroxylation enhances neurotoxic potency. Brain Research 437:1, pages 69-76.
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PETER G. WISLOCKI, GERALD T. MIWA & ANTHONY Y.H. LU. 1980. Enzymatic Basis of Detoxication. Enzymatic Basis of Detoxication 135 182 .
R. Kato. (1979) Characteristics and differences in the hepatic mixed function oxidase of different species. Pharmacology & Therapeutics 6:1, pages 41-98.
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Neal CastagnoliJr.Jr.. 1978. Stimulants. Stimulants 335 387 .

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