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Xenobiotica
the fate of foreign compounds in biological systems
Volume 5, 1975 - Issue 12
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Research Article

Identification of Cyclobenzaprine-10, 11-Epoxide and other Metabolites after Incubation of Cyclobenzaprine with Rat Liver Microsomes

G. Belvedere Istituto di Ricerche Farmacologiche “Mario Negri”, Via Eritrea, 62-20157, Milan, Italy
,
V. Rovei Istituto di Ricerche Farmacologiche “Mario Negri”, Via Eritrea, 62-20157, Milan, Italy
,
C. Pantarotto Istituto di Ricerche Farmacologiche “Mario Negri”, Via Eritrea, 62-20157, Milan, Italy
&
A. Frigerio Istituto di Ricerche Farmacologiche “Mario Negri”, Via Eritrea, 62-20157, Milan, Italy
Pages 765-771 | Received 08 Apr 1975, Published online: 14 Oct 2008

Citations (13)

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G. Bellucci, C. Chiappe, F. Marioni & C. Simonelli. (1989) The low reactivity of 5H-dibenzo[a, cflcycloheptene 10,ll-oxide in microsomal epoxide hydrolase catalysed hydration. Xenobiotica 19:3, pages 279-285.
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A. Frigerio, M. Cavo-briones & G. Belvedere. (1976) Formation of Stable Epoxides in the Metabolism of Tricyclic Drugs. Drug Metabolism Reviews 5:2, pages 197-218.
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J. Pachecka, M. Salmona, L. Cantoni, E. Mussini, C. Pantarotto, A. Frigerio & G. Belvedere. (1976) Activity of liver microsomal mono-oxygenases on some epoxide-forming tricyclic drugs. I. Kinetics in vitro. Xenobiotica 6:10, pages 593-598.
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Articles from other publishers (10)

Yan Liu, Dantong Zhao & Zhongxi (Zack) Zhao. (2014) Study of degradation mechanisms of cyclobenzaprine by LC-MS/MS. Anal. Methods 6:7, pages 2320-2330.
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Jinghua Yu. 2014. Handbook of Metabolic Pathways of Xenobiotics. Handbook of Metabolic Pathways of Xenobiotics 1 5 .
Meredith L Cotton & G.R. Brian Down. 1988. 41 72 .
M. H. Bickel. 1980. Psychotropic Agents. Psychotropic Agents 551 572 .
A. Frigerio, P. Negrini, L. Cappellini, D. Rotilio, A. De Pascale & E. Rossi. (1979) In vitro studies on the metabolism of dibenzo[c,f]-[1,2]diazepine. European Journal of Drug Metabolism and Pharmacokinetics 4:1, pages 35-41.
Crossref
A. Frigerio, P. Negrini, D. Rotilio, A. De Pascale & E. Rossi. 1979. Recent Developments in Mass Spectrometry in Biochemistry and Medicine. Recent Developments in Mass Spectrometry in Biochemistry and Medicine 9 25 .
Neal CastagnoliJr.Jr.. 1978. Stimulants. Stimulants 335 387 .
A. Frigerio, J. Lanzoni, C. Pantarotto, E. Rossi, V. Rovei & M. Zanol. (1977) Epoxide-diol metabolic pathway of cytenamide in the rat. Journal of Chromatography A 134:2, pages 299-305.
Crossref
C. Pantarotto, L. Cappellini, P. Negrini & A. Frigerio. (1977) “Epoxide-diol” metabolic pathway of 5H-dibenzo[a,d]cycloheptene in the rat. Journal of Chromatography A 131, pages 430-436.
Crossref
A. Frigerio & C. Pantarotto. 1977. Mass Spectrometry in Drug Metabolism. Mass Spectrometry in Drug Metabolism 251 276 .

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