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Xenobiotica
the fate of foreign compounds in biological systems
Volume 6, 1976 - Issue 1
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Original Article

Effects of Insecticide Synergists on Microsomal Oxidation of Estradiol and Ethynylestradiol and on Microsomal Drug Metabolism

Hermann M. Bolt Institute of Toxicology, University of Tubingen, D-74, Tubingen, Germany
&
Helmut Kassel Institute of Toxicology, University of Tubingen, D-74, Tubingen, Germany
Pages 33-38 | Received 24 Jun 1975, Published online: 30 Sep 2009

Citations (16)

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Bernard Testa & Peter Jenner. (1981) Inhibitors of Cytochrome P-450s and Their Mechanism of Action. Drug Metabolism Reviews 12:1, pages 1-117.
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Articles from other publishers (15)

Hsia-lien Lin, Ute M. Kent & Paul F. Hollenberg. (2002) Mechanism-Based Inactivation of Cytochrome P450 3A4 by 17α-Ethynylestradiol: Evidence for Heme Destruction and Covalent Binding to Protein. Journal of Pharmacology and Experimental Therapeutics 301:1, pages 160-167.
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F. Peter Guengerich. (1990) Inhibition of oral contraceptive steroid—metabolizing enzymes by steroids and drugs. American Journal of Obstetrics and Gynecology 163:6, pages 2159-2163.
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F. Peter Guengerich. (1990) Metabolism of 17 α-ethynylestradiol in humans. Life Sciences 47:22, pages 1981-1988.
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HS Purba, JL Maggs, ML Orme, DJ Back & BK Park. (2012) The metabolism of 17 alpha‐ethinyloestradiol by human liver microsomes: formation of catechol and chemically reactive metabolites.. British Journal of Clinical Pharmacology 23:4, pages 447-453.
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Harpal S. Purba, David J. Back & Alasdair M. Breckenridge. (1986) Inhibition of estrogen 2-hydroxylase. Journal of Steroid Biochemistry 24:5, pages 1091-1093.
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Judith H. Riviere & D.J. Back. (1986) Inhibition of ethinyloestradiol and tolbutamide metabolism by quinoline derivatives in vitro. Chemico-Biological Interactions 59, pages 301-308.
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H. M. Bolt. (1985) Arzneimittelinteraktionen bei der Anwendung von Steroidhormonen, insbesondere von oralen Kontrazeptive. Archives of Gynecology 238:1-4, pages 717-723.
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Judith H. Riviere & D.J. Back. (1985) Effect of mefloquine on hepatic drug metabolism in the rat: Comparative study with primaquine. Biochemical Pharmacology 34:4, pages 567-571.
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DJ Back, JL Maggs, HS Purba, S Newby & BK Park. (2012) 2‐Hydroxylation of ethinyloestradiol in relation to the oxidation of sparteine and antipyrine.. British Journal of Clinical Pharmacology 18:4, pages 603-607.
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H.M. Bolt. (1979) Effects on endocrine systems by influencing hepatic metabolism of steroid hormones. Pharmacology & Therapeutics 5:1-3, pages 365-368.
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H.M. Bolt. (1979) Metabolism of estrogens—natural and synthetic. Pharmacology & Therapeutics 4:1, pages 155-181.
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C.-P. Siegers, J.G. Filser & H.M. Bolt. (1978) Effect of dithiocarb on metabolism and covalent binding of carbon tetrachloride. Toxicology and Applied Pharmacology 46:3, pages 709-716.
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H.M. Bolt, R.J. Laib, H. Kappus & A. Buchter. (1977) Pharmacokinetics of vinyl chloride in the rat. Toxicology 7:2, pages 179-188.
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H. M. Bolt, A. Buchter, L. Wolowski, D. L. Gil & W. Bolt. (1977) Incubation of 14C-trichloroethylene vapor with rat liver microsomes: Uptake of radioactivity and covalent protein binding of metabolites. International Archives of Occupational and Environmental Health 39:2, pages 103-111.
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H. M. Bolt, H. Kappus, A. Buchter & W. Bolt. (1976) Disposition of [1,2-14C] vinyl chloride in the rat. Archives of Toxicology 35:3, pages 153-162.
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