Advanced search
Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 6, 1976 - Issue 1
Submit an article Journal homepage
30
Views
32
CrossRef citations to date
0
Altmetric
Original Article

Reaction Pathways of in vivo Stereoselective Conversion of Ethylbenzene to (-)-Mandelic Acid

Hugh R. Sullivan The Lilly Research Laboratories, Indianapolis, Indiana, 46206, USA
,
Warren M. Miller The Lilly Research Laboratories, Indianapolis, Indiana, 46206, USA
&
Robert E. McMahon The Lilly Research Laboratories, Indianapolis, Indiana, 46206, USA
Pages 49-54 | Received 10 Jun 1975, Published online: 30 Sep 2009

Citations (32)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (6)

FrederickE. Goetz & HolgerW. Jannasch. (1993) Aromatic hydrocarbon‐degrading bacteria in the petroleum‐rich sediments of the guaymas basin hydrothermal vent site: Preference for aromatic carboxylic acids. Geomicrobiology Journal 11:1, pages 1-18.
Read now
L. Drummond, J. Caldwell & H. K. Wilson. (1990) The stereoselectivity of 1,2-phenylethanediol and mandelic acid metabolism and disposition in the rat. Xenobiotica 20:2, pages 159-168.
Read now
L. Drummond, J. Caldwell & H. K. Wilson. (1989) The metabolism of ethylbenzene and styrene to mandelic acid: Stereochemical considerations. Xenobiotica 19:2, pages 199-207.
Read now
E. Elovaara, K. Engström, J. Nickels, A. Aito & H. Vainio. (1985) Biochemical and morphological effects of long-term inhalation exposure of rats to ethylbenzene. Xenobiotica 15:4, pages 299-308.
Read now
Hugh R. Sullivan, Robert E. McMahon, Patrick Roffey, Donald G. Hoffman, Frederick J. Marshall, Ruth E. Billings, Donald N. Benslay & Winston S. Marshall. (1978) Isopropylbiphenyl Metabolism in the Rat. Relationships between Metabolism, Pharmacology and Toxicology. Xenobiotica 8:6, pages 333-340.
Read now
Märeen J. Crawford, D. H. Hutson & Päline A. King. (1976) Metabolic Demethylation of the Insecticide Dimethyl-vinphos in Rats, in Dogs, and in vitro. Xenobiotica 6:12, pages 745-762.
Read now

Articles from other publishers (26)

Elmira Meghrazi Ahadi, Fatemeh Hajipour & Loghman Firoozpour. 2024. Encyclopedia of Toxicology. Encyclopedia of Toxicology 275 279 .
John L. O'Donoghue. 2003. Patty's Toxicology. Patty's Toxicology 1 111 .
D. Belsito, D. Bickers, M. Bruze, P. Calow, M.L. Dagli, A.D. Fryer, H. Greim, Y. Miyachi, J.H. Saurat & I.G. Sipes. (2012) A toxicological and dermatological assessment of aryl alkyl alcohol simple acid ester derivatives when used as fragrance ingredients. Food and Chemical Toxicology 50, pages S269-S313.
Crossref
John L. O'Donoghue. 2003. Patty's Toxicology. Patty's Toxicology 807 914 .
. (2011) Scientific Opinion on Flavouring Group Evaluation 17, Revision 3 (FGE.17Rev3): Pyrazine derivatives from chemical group 24. EFSA Journal 9:11.
Crossref
. (2011) Scientific Opinion on Flavouring Group Evaluation 22, Revision 1 (FGE.22Rev1): Ring‐substituted phenolic substances from chemical groups 21 and 25. EFSA Journal 9:5.
Crossref
. (2011) Scientific Opinion on Flavouring Group Evaluation 17, Revision 2 (FGE.17Rev2): Pyrazine derivatives from chemical group 24. EFSA Journal 9:5.
Crossref
. (2009) Flavouring Group Evaluation 16, Revision 2 (FGE.16Rev2): Aromatic ketones from chemical group 21. EFSA Journal 7:12, pages 1022.
Crossref
. (2008) Flavouring Group Evaluation 16, Revision 1 (FGE.16Rev1): Aromatic ketones from chemical group 21‐ Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food. EFSA Journal 6:10.
Crossref
. (2008) Flavouring Group Evaluation 17, Revision 1 (FGE.17Rev1): Pyrazine derivatives from chemical group 24 - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC). EFSA Journal 6:9, pages 812.
Crossref
. (2008) Flavouring Group Evaluation 48: Aminoacetophenone from chemical group 33. EFSA Journal 6:9, pages 797.
Crossref
. (2007) Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Flavouring Group Evaluation 22 (FGE.22): Ring‐substituted phenolic substances from chemical groups 21 and 25 (Commission Regulation (EC) No 1565/2000 of 18 July 2000). EFSA Journal 5:5.
Crossref
T.B. Adams, M.M. McGowen, M.C. Williams, S.M. Cohen, V.J. Feron, J.I. Goodman, L.J. Marnett, I.C. Munro, P.S. Portoghese, R.L. Smith & W.J. Waddell. (2007) The FEMA GRAS assessment of aromatic substituted secondary alcohols, ketones, and related esters used as flavor ingredients. Food and Chemical Toxicology 45:2, pages 171-201.
Crossref
. (2006) Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Flavouring Group Evaluation 16 (FGE.16): Aromatic ketones from chemical group 21 (Commission Regulation (EC) No 1565/2000 o. EFSA Journal 4:8, pages 330.
Crossref
. (2006) Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the Commission related to Flavouring Group Evaluation 17 (FGE.17): Pyrazine derivatives from chemical group 24 (Comm. EFSA Journal 4:1, pages 295.
Crossref
Douglas C. Topping, David A. Morgott & John L. O'Donoghue. 2003. Patty's Toxicology. Patty's Toxicology.
M. Korn, W. Gfr�rer, R. Herz, I. Wodarz & R. Wodarz. (1992) Stereometabolism of ethylbenzene in man: gas chromatographic determination of urinary excreted mandelic acid enantiomers and phenylglyoxylic acid and their relation to the height of occupational exposure. International Archives of Occupational and Environmental Health 64:2, pages 75-78.
Crossref
Wolfgang Maret. 1991. Enzymology and Molecular Biology of Carbonyl Metabolism 3. Enzymology and Molecular Biology of Carbonyl Metabolism 3 327 336 .
Charles A. Fewson. (1988) Microbial metabolism of mandelate: a microcosm of diversity. FEMS Microbiology Letters 54:2, pages 85-110.
Crossref
Lawrence Fishbein. (1985) An overview of environmental and toxicological aspects of aromatic hydrocarbons IV. Ethylbenzene. Science of The Total Environment 44:3, pages 269-287.
Crossref
K. Engstr�m, V. Riihim�ki & A. Laine. (1984) Urinary disposition of ethylbenzene and m-xylene in man following separate and combined exposure. International Archives of Occupational and Environmental Health 54:4, pages 355-363.
Crossref
Eivor Elovaara, Kerstin Engström & Harri Vainio. (1984) Metabolism and disposition of simultaneously inhaled m-xylene and ethylbenzene in the rat. Toxicology and Applied Pharmacology 75:3, pages 466-478.
Crossref
ROBERT E. MCMAHON. 1982. Metabolic Basis of Detoxication. Metabolic Basis of Detoxication 91 104 .
Bernard Testa, Jean-Claude Bünzli & William P. Purcell. (1978) Regioelectronic factors in metabolic hydroxylation of aliphatic carbon atoms. Journal of Theoretical Biology 70:4, pages 339-344.
Crossref
E. Roseland Klein & Peter D. Klein. (1978) A selected bibliography of biomedical and environmental applications of stable isotopes. I—Deuterium 1971-1976. Biological Mass Spectrometry 5:2, pages 91-111.
Crossref
Lawrence K. Low & Neal CastagnoliJr.Jr.. 1978. 304 315 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.