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Xenobiotica
the fate of foreign compounds in biological systems
Volume 6, 1976 - Issue 4
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Original Article

Comparative Metabolic Studies of Phenacetin and Structurally-related Compounds in the Rat

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Pages 217-236 | Received 14 Sep 1975, Published online: 30 Sep 2009

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A. W. NICHOLLS, J. C. LINDON, S. CADDICK, R. D. FARRANT, I. D. WILSON & J. K. NICHOLSON. (1997) NMR spectroscopic studies on the metabolism and futile deacetylation of phenacetin in the rat. Xenobiotica 27:11, pages 1175-1186.
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A. P. Glazier, G. O. Kokwaro, S. Ismail & G. Edwards. (1994) Effect of an experimental malaria infection on the metabolism of phenacetin in the rat isolated perfused liver. Xenobiotica 24:8, pages 785-793.
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D. Hesk, D. H. Hutson & C. J. Logan. (1988) The fate of 4-cyanoacetanilide in rats and mice; mechanism of formation of a novel electrophilic metabolite. Xenobiotica 18:8, pages 955-966.
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Glenn F. Rush, Jacqueline H. Smith, John F. Newton, Jerry B. Hook & William O. Berndt. (1984) Chemically Induced Nephrotoxicity: Role of Metabolic Activation. CRC Critical Reviews in Toxicology 13:2, pages 99-160.
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Herman A. J. Schut & Andre Castonguay. (1984) Metabolism of Carcinogenic Amino Derivatives in Various Species and DNA Alkylation by Their Metabolites. Drug Metabolism Reviews 15:4, pages 753-839.
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R. H. Clothier, Jane R. Dewar, Maria Ana Santos, A. D. North, Susan Foster & M. Balls. (1981) A comparative study of the deacetylation of paracetamol by urodele and anuran amphibian organ cultures. Xenobiotica 11:3, pages 149-157.
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P. H. Grantham, T. Benjamin, L. C. Tahan, P. P. Roller, J. R. Miller & E. K. Weisburger. (1979) Metabolism of the dyestuff intermediate 2,4-diaminoanisole in the rat. Xenobiotica 9:6, pages 333-341.
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Articles from other publishers (30)

H. Bahrami & H. Salehabadi. (2015) Experimental and theoretical investigation of para-aminophenol ionization in corona discharge. Journal of Molecular Structure 1083, pages 330-335.
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A J M Seegers, L P Jager & J van Noordwijk. (1979) Effects of phenacetin, paracetamol and caffeine on the erosive activity of acetylsalicylic acid in the rat stomach: dose-response relationships, time course of erosion development and effects on acid secretion. Journal of Pharmacy and Pharmacology 31:1, pages 840-848.
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Rie Yoshida, Shinji Oikawa, Yasutaka Ogawa, Yuichi Miyakoshi, Motoi Ooida, Kazunari Asanuma & Hidesuke Shimizu. (1998) Mutagenicity of p-aminophenol in E. coli WP2uvrA/pKM101 and its relevance to oxidative DNA damage. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 415:1-2, pages 139-150.
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Andrew W Nicholls, R Duncan Farrant, John P Shockcor, Steve E Unger, Ian D Wilson, John C Lindon & Jeremy K Nicholson. (1997) NMR and HPLC-NMR spectroscopic studies of futile deacetylation in paracetamol metabolites in rat and man. Journal of Pharmaceutical and Biomedical Analysis 15:7, pages 901-910.
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Suk K. Hong, Monica A. Valentovic, Dianne K. Anestis, John G. Ball, Patrick I. Brown & Gary O. Rankin. (1996) Nephrotoxicity of 4-amino-2-chlorophenol and 2-amino-4-chlorophenol in the Fischer 344 rat. Toxicology 110:1-3, pages 47-58.
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Lynn M. Fowler, John R. Foster & Edward A. Lock. (1993) Effect of ascorbic acid, acivicin and probenecid on the nephrotoxicity of 4-aminophenol in the Fischer 344 rat. Archives of Toxicology 67:9, pages 613-621.
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Chung-Li J. Li & Margaret O. James. (1993) Glucose and sulfate conjugations of phenol, β-naphthol and 3-hydroxybenzo[a]pyrene by the American lobster (Homarus americanus). Aquatic Toxicology 26:1-2, pages 57-71.
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Lynn M. Fowler, Richard B. Moore, John R. Foster & Edward A. Lock. (2016) Nephrotoxicity of 4-Aminophenol Glutathione Conjugate. Human & Experimental Toxicology 10:6, pages 451-459.
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Kevin P. R. Gartland, Frank W. Bonner, John A. Timbrell & Jeremy K. Nicholson. (1989) Biochemical characterisation of para-aminophenol-induced nephrotoxic lesions in the F344 rat. Archives of Toxicology 63:2, pages 97-106.
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Steven P. Djordjevic, Nicholas K. Hayward & Martin F. Lavin. (1986) Effect of N-hydroxyparacetamol on cell cycle progression. Biochemical Pharmacology 35:20, pages 3511-3516.
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N.K. Hayward & M.F. Lavin. (1985) p-Aminophenol induced DNA damage and cytotoxicity enhanced by autoxidation. Life Sciences 36:21, pages 2039-2046.
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BOJAN FLAKS, ANTONIA FLAKS & ANDREW P. W. SHAW. (2009) INDUCTION BY PARACETAMOL OF BLADDER AND LIVER TUMOURS IN THE RAT. Acta Pathologica Microbiologica Scandinavica Series A :Pathology 93A:1-6, pages 367-377.
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Humeida A. El-Obeid & Abdullah A. Al-Badr. 1985. 551 596 .
Rolf Mentlein & Eberhard Heymann. (1984) Hydrolysis of ester- and amide-type drugs by the purified isoenzymes of nonspecific carboxylesterase from rat liver. Biochemical Pharmacology 33:8, pages 1243-1248.
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H.-J. Altman & W. Grunow. (1983) Distribution and excretion of orally administered oleic acid anilide in the rat. Toxicology 27:3-4, pages 321-326.
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M. Balls & R. Clothier. (2009) Differentiated cell and organ culture in toxicity testing.. Acta Pharmacologica et Toxicologica 52, pages 115-137.
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Joachim Baumann, Franz V. Bruchhausen & Gotthard Wurm. (1983) Inhibition of prostaglandin synthetases derived from neuronal and glial cells and rat renal medulla by ortho-, meta- and para-substituted aminophenolic compounds. Prostaglandins, Leukotrienes and Medicine 10:3, pages 319-329.
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E. Kunze, H.-H. W�ltjen, B. Hartmann & W. Engelhardt. (1983) Animal experiments regarding a possible carcinogenic effect of phenacetin on the resting and proliferating urothelium stimulated by cyclophosphamide. Journal of Cancer Research and Clinical Oncology 105:1, pages 38-47.
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J.F. Newton, C.-H. Kuo, M.W. Gemborys, G.H. Mudge & J.B. Hook. (1982) Nephrotoxicity of p-aminophenol, a metabolite of acetaminophen, in the Fischer 344 rat. Toxicology and Applied Pharmacology 65:2, pages 336-344.
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S. J. Hart, I. C. Calder & J. D. Tange. (1982) The metabolism and toxicity of paracetamol in Sprague-Dawley and wistar rats. European Journal of Drug Metabolism and Pharmacokinetics 7:3, pages 203-222.
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Michael BallsSteven Horner. (2020) Cell and Organ Cultures as Alternatives in Toxicity Testing. Alternatives to Laboratory Animals 10:1, pages 16-26.
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Nicholas K. Hayward, Martin F. Lavin & Peter W. Craswell. (1982) Inhibition of DNA synthesis and alteration to DNA structure by the phenacetin analog p-aminophenol. Biochemical Pharmacology 31:7, pages 1425-1429.
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Richard H. Clothier, Michael Balls, Gary S. Hostry, Neil J. Robertson & Steven A. Horner. (1982) Amphibian organ culture in experimental toxicology: The effects of paracetamol and phenacetin on cultured tissues from urodele and anuran amphibians. Toxicology 25:1, pages 31-40.
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S.J. Hart, R. Tontodonati & I.C. Calder. (1981) Reversed-phase chromatography of urinary metabolites of paracetamol using ion suppression and ion pairing. Journal of Chromatography B: Biomedical Sciences and Applications 225:2, pages 387-405.
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Lowie P. Jager, Ad J. M. Seegers & J. van Noordwijk. 1981. The Prostaglandin System. The Prostaglandin System 401 415 .
A. J. M. Seegers. (1980) Zijn combinaties van niet-narcotische analgetica rationeel?Are non-narcotic analgesic drug mixtures rational?. Pharmaceutisch Weekblad Scientific Edition 2:1, pages 1133-1142.
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Roland Grafström, Kari Ormstad, Peter Moldéus & Stem Orrenius. (1979) Paracetamol metabolism in the isolated perfused rat liver with further metabolism of a biliary paracetamol conjugate by the small intestine. Biochemical Pharmacology 28:24, pages 3573-3579.
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Stuart McLean. (1978) Metabolism of phenacetin and N-hydroxyphenacetin in isolated rat hepatocytes. Naunyn-Schmiedeberg's Archives of Pharmacology 305:2, pages 173-180.
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. 1978. 21 44 .
G. E. Smith & L. A. Griffiths. (1976) Metabolism of a biliary metabolite of phenacetin and other acetanilides by the intestinal microflora. Experientia 32:12, pages 1556-1557.
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