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Xenobiotica
the fate of foreign compounds in biological systems
Volume 6, 1976 - Issue 4
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Original Article

Paracetamol Metabolism in the Rat: Relationship to Covalent Binding and Hepatic Damage

M. Davis The Liver Unit, King's College Hospital and Medical School, Denmark Hill, London, SE5 8RX, UK
,
N. G. Harrison The Liver Unit, King's College Hospital and Medical School, Denmark Hill, London, SE5 8RX, UK
,
G. Ideo The Liver Unit, King's College Hospital and Medical School, Denmark Hill, London, SE5 8RX, UK
,
B. Portmann The Liver Unit, King's College Hospital and Medical School, Denmark Hill, London, SE5 8RX, UK
,
D. Labadarios The Liver Unit, King's College Hospital and Medical School, Denmark Hill, London, SE5 8RX, UK
&
Roger Williams The Liver Unit, King's College Hospital and Medical School, Denmark Hill, London, SE5 8RX, UK
Pages 249-255 | Received 25 Jul 1975, Published online: 30 Sep 2009

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A. A. Horton, Steven Fairhurst & James S. Bus. (1987) Lipid Peroxidation and Mechanisms of Toxicity. CRC Critical Reviews in Toxicology 18:1, pages 27-79.
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J. Michael Tredger, H. M. Smith, R. B. Read & R. Williams. (1986) Effects of ethanol ingestion on the metabolism of a hepatotoxic dose of paracetamol in mice. Xenobiotica 16:7, pages 661-670.
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E. J. Ariëns. (1984) Domestication of Chemistry by Design of Safer Chemicals: Structure-Activity Relationships. Drug Metabolism Reviews 15:3, pages 425-504.
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K. Healey, I. C. Calder, A. C. Yong, C. A. Crowe, C. C. Funder, K. N. Ham & J. D. Tange. (1978) Liver and Kidney Damage Induced by N-Hydroxyparacetamol. Xenobiotica 8:7, pages 403-411.
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Articles from other publishers (20)

Mira Merdas, Mélanie Lagarrigue, Thierry Umbdenstock, Antoine Lhumeau, Françoise Dartiguelongue, Quentin Vanbellingen, Georges Da Violante & Charles Pineau. (2021) Study of the Distribution of Acetaminophen and Its Metabolites in Rats, from the Whole-Body to Isolated Organ Levels, by Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging after On-Tissue Chemical Derivatization. Analytical Chemistry 93:39, pages 13242-13250.
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Q. Sun, T. W. Harper, E. A. Dierks, L. Zhang, S. Chang, A. D. Rodrigues & P. Marathe. (2011) 1-Aminobenzotriazole, a Known Cytochrome P450 Inhibitor, Is a Substrate and Inhibitor of N -Acetyltransferase . Drug Metabolism and Disposition 39:9, pages 1674-1679.
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Y.B. Solanki & S.M. Jain. (2010) Hepatoprotective Effects of Clitoria ternatea and Vigna mungo against Acetaminophen and Carbon tetrachloride-induced Hepatotoxicity in Rats. Journal of Pharmacology and Toxicology 6:1, pages 30-48.
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Hadi Shafiei, Mohammad Haqgu, Davood Nematollahi & Mohammad R. Gholami. (2008) An Experimental and Computational Study on the Rate Constant of Electrochemically Generated N-Acetyl-p-Quinoneimine with Dimethylamine. International Journal of Electrochemical Science 3:10, pages 1092-1107.
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Hiroshi Takada, Emmanuel Mawet, Yasushi Shiratori, Yohko Hikiba, Ryo Nakata, Haruhiko Yoshida, Ken'ichi Okano, Kazuo Kamii & Masao Omata. (1995) Chemotactic factors released from hepatocytes exposed to acetaminophen. Digestive Diseases and Sciences 40:8, pages 1831-1836.
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Timothy L. Dunn, Robert A. Gardiner, Gregory J. Seymour & Martin F. Lavin. (1987) Genotoxicity of analgesic compounds assessed by an in vitro micronucleus assay. Mutation Research/Genetic Toxicology 189:3, pages 299-306.
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BOJAN FLAKS, ANTONIA FLAKS & ANDREW P. W. SHAW. (2009) INDUCTION BY PARACETAMOL OF BLADDER AND LIVER TUMOURS IN THE RAT. Acta Pathologica Microbiologica Scandinavica Series A :Pathology 93A:1-6, pages 367-377.
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Christopher H. Linden & Barry H. Rumack. (1984) Acetaminophen Overdose. Emergency Medicine Clinics of North America 2:1, pages 103-119.
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Barry H. Rumack. (1983) Acetaminophen overdose. The American Journal of Medicine 75:5, pages 104-112.
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Nobutoshi Watari, Masuaki Iwai & Nobuyoshi Kaneniwa. (1983) Pharmacokinetic study of the fate of acetaminophen and its conjugates in rats. Journal of Pharmacokinetics and Biopharmaceutics 11:3, pages 245-272.
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S. J. Hart, I. C. Calder & J. D. Tange. (1982) The metabolism and toxicity of paracetamol in Sprague-Dawley and wistar rats. European Journal of Drug Metabolism and Pharmacokinetics 7:3, pages 203-222.
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K.Sandy Pang & Julia A. Terrell. (1981) Conjugation kinetics of acetaminophen by the perfused rat liver preparation. Biochemical Pharmacology 30:14, pages 1959-1965.
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J. de Vries. (1981) Hepatotoxic metabolic activation of paracetamol and its derivatives phenacetin and benorilete: Oxygenation or electron transfer?. Biochemical Pharmacology 30:5, pages 399-402.
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W. Bolanowska & T. Gessner. (1980) Drug interactions with acetaminophen. Biochemical Pharmacology 29:8, pages 1167-1175.
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Roland Grafström, Kari Ormstad, Peter Moldéus & Stem Orrenius. (1979) Paracetamol metabolism in the isolated perfused rat liver with further metabolism of a biliary paracetamol conjugate by the small intestine. Biochemical Pharmacology 28:24, pages 3573-3579.
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Kay E. Porter & Anthony G. Dawson. (1979) Inhibition of respiration and gluconeogenesis by paracetamol in rat kidney preparations. Biochemical Pharmacology 28:20, pages 3057-3062.
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Bruce H. Migdalof. 1978. 196 205 .
Peter Moldéus. (1978) Paracetamol metabolism and toxicity in isolated hepatocytes from rat and mouse. Biochemical Pharmacology 27:24, pages 2859-2863.
Crossref
Neal CastagnoliJr.Jr.. 1978. Stimulants. Stimulants 335 387 .
D. Labadarios, M. Davis, B. Portmann & Roger Williams. (1977) Paracetamol-induced hepatic necrosis in the mouse—Relationship between covalent binding, hepatic glutathione depletion and the protective effect of α-mercaptopropionylglycine. Biochemical Pharmacology 26:1, pages 31-35.
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