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Xenobiotica
the fate of foreign compounds in biological systems
Volume 6, 1976 - Issue 6
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Original Article

The Binding of Trichlorofluoromethane and other Haloalkanes to Cytochrome P-450 under Aerobic and Anaerobic Conditions

Peter J. Cox Department of Biochemistry, University of Surrey, Guildford, Surrey, UK
,
Laurence J. King Department of Biochemistry, University of Surrey, Guildford, Surrey, UK
&
Dennis V. Parke Department of Biochemistry, University of Surrey, Guildford, Surrey, UK
Pages 363-375 | Received 25 Sep 1975, Published online: 30 Sep 2009

Citations (18)

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Read on this site (3)

Dennis V. Parke. (1997) A History of Drug Metabolism in the United Kingdom. Drug Metabolism Reviews 29:3, pages 801-851.
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W. M. H. Heijbroek, D. F. Muggleton & D. V. Parke. (1984) Metabolism of the carbamate herbicide, asulam, in the rat. Xenobiotica 14:3, pages 235-247.
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Sonja Poplawski-Tabarelli & H. Uehleke. (1982) Inhibition of microsomal drug oxidations by aliphatic halohydrocarbons: correlation with vapour pressure. Xenobiotica 12:1, pages 55-61.
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Articles from other publishers (15)

Jon B. Reid & Custodio V. Muianga. 2003. Patty's Toxicology. Patty's Toxicology 61 127 .
Maria Almira Correia & Paul R. Ortiz de Montellano. 2005. Cytochrome P450. Cytochrome P450 247 322 .
Jon B. Reid. 2003. Patty's Toxicology. Patty's Toxicology.
Paul R. Ortiz de Montellano & Maria Almira Correia. 1995. Cytochrome P450. Cytochrome P450 305 364 .
Sumsullah Khan, Christian Sood & Peter J. O'Brlen. (1993) Molecular mechanisms of dibromoalkane cytotoxicity in isolated rat hepatocytes. Biochemical Pharmacology 45:2, pages 439-447.
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Paul R. Ortiz de Montellano. (1990) Free radical modification of prosthetic heme groups. Pharmacology & Therapeutics 48:1, pages 95-120.
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Emanuela Testai & Luciano Vittozzi. (1986) Biochemical alterations elicited in rat liver microsomes by oxidation and reduction products of chloroform metabolism. Chemico-Biological Interactions 59, pages 157-171.
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Paul R. Ortiz de Montellano & Norbert O. Reich. 1986. Cytochrome P-450. Cytochrome P-450 273 314 .
Brian T. Luke & Gilda H. Loew. (2009) A theoretical investigation of the first step in the metabolic reduction of halogenated methanes by cytochrome P-450. International Journal of Quantum Chemistry 28:S12, pages 99-112.
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Paul R. Ortiz de Montellano. 1984. 201 211 .
Sally N. McCall, Peter Jurgens & Kathryn M. Ivanetich. (1983) Hepatic microsomal metabolism of the dichloroethanes. Biochemical Pharmacology 32:2, pages 207-213.
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W. Nastainczyk, H.J. Ahr & V. Ullrich. (1982) The reductive metabolism of halogenated alkanes by liver microsomal cytochrome P450. Biochemical Pharmacology 31:3, pages 391-396.
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M.W. ANDERS. 1982. Metabolic Basis of Detoxication. Metabolic Basis of Detoxication 29 49 .
William M. Kluwe, Robert McNish, Kenneth Smithson & Jerry B. Hook. (1981) Depletion by 1,2-dibromoethane, 1,2-dibromo-3-chloropropane, tris(2,3-dibromopropyl)phosphate,and hexachloro-1,3-butadiene of reduced non-protein sulfhydryl groups in target and non-target organs. Biochemical Pharmacology 30:16, pages 2265-2271.
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C.Roland Wolf, Laurence J. King & Dennis V. Parke. (1978) The anaerobic dechlorination of trichlorofluoro-methane by rat liver preparations in vitro. Chemico-Biological Interactions 21:2-3, pages 277-288.
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