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Xenobiotica
the fate of foreign compounds in biological systems
Volume 6, 1976 - Issue 7
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Original Article

Metabolism of Debrisoquine Sulphate in Rat, Dog and Man

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Pages 405-409 | Received 28 Sep 1975, Published online: 30 Sep 2009

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Jie Cheng, Yueying Zhen, Sharon Miksys, Diren Beyoğlu, Kristopher W. Krausz, Rachel F. Tyndale, Aiming Yu, Jeffrey R. Idle & Frank J. Gonzalez. (2013) Potential role of CYP2D6 in the central nervous system. Xenobiotica 43:11, pages 973-984.
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Chi Chen, Frank J. Gonzalez & Jeffrey R. Idle. (2007) LC-MS-Based Metabolomics in Drug Metabolism. Drug Metabolism Reviews 39:2-3, pages 581-597.
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B. Clark, D. A. Smith, C. T. Eason & D. V. Parke. (1982) Metabolism and excretion of a chromone carboxylic acid (FPL 52757) in various animal species. Xenobiotica 12:3, pages 147-153.
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J. R. Idle & R. L. Smith. (1979) Polymorphisms of Oxidation at Carbon Centers of Drugs and Their Clinical Significance. Drug Metabolism Reviews 9:2, pages 301-317.
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Articles from other publishers (11)

Brian R. Cooke, S. W. Annie Bligh, Z. Richard Cybulski, Costas Ioannides & Michael Hall. (2012) Debrisoquine Metabolism and CYP2D Expression in Marmoset Liver Microsomes. Drug Metabolism and Disposition 40:1, pages 70-75.
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Hidetaka Kamimura, Naoyuki Nakada, Katsuhiro Suzuki, Ayako Mera, Kinya Souda, Yuichi Murakami, Kohichiro Tanaka, Takafumi Iwatsubo, Akio Kawamura & Takashi Usui. (2010) Assessment of Chimeric Mice with Humanized Liver as a Tool for Predicting Circulating Human Metabolites. Drug Metabolism and Pharmacokinetics 25:3, pages 223-235.
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Yueying Zhen, Ondřej Slanař, Kristopher W. Krausz, Chi Chen, Josef Slavík, Kerry L. McPhail, T. Mark Zabriskie, František Perlík, Frank J. Gonzalez & Jeffrey R. Idle. (2006) 3,4-Dehydrodebrisoquine, a Novel Debrisoquine Metabolite Formed from 4-Hydroxydebrisoquine That Affects the CYP2D6 Metabolic Ratio. Drug Metabolism and Disposition 34:9, pages 1563-1574.
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Javier Corchero, Camille P. Granvil, Taro E. Akiyama, Graham P. Hayhurst, Satish Pimprale, Lionel Feigenbaum, Jeffrey R. Idle & Frank J. Gonzalez. (2001) The CYP2D6 Humanized Mouse: Effect of the Human CYP2D6 Transgene and HNF4α on the Disposition of Debrisoquine in the Mouse . Molecular Pharmacology 60:6, pages 1260-1267.
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C. Goubier, I. Girard & S. Ferry. (1991) High-performance liquid chromatographic assay of debrisoquine and its 4-hydroxy metabolite in human urine. Chromatographia 32:11-12, pages 523-526.
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M Eichelbaum, L Bertilsson, A Kupfer, E Steiner & CO Meese. (2012) Enantioselectivity of 4‐hydroxylation in extensive and poor metabolizers of debrisoquine.. British Journal of Clinical Pharmacology 25:4, pages 505-508.
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BK Park. (2012) Assessment of the drug metabolism capacity of the liver.. British Journal of Clinical Pharmacology 14:5, pages 631-651.
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S. Murray & K. A. Waddell. (1982) The electron capture negative ion chemical ionization mass spectra of 2-(4′,6′-bistrifluoromethyl-2′-pyrimidinyl)-tetrahydroisoquinoline and 4-substituted analogues. Biological Mass Spectrometry 9:11, pages 466-472.
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GC Kahn, AR Boobis, S Murray, MJ Brodie & DS Davies. (2012) Assay and characterisation of debrisoquine 4‐hydroxylase activity of microsomal fractions of human liver.. British Journal of Clinical Pharmacology 13:5, pages 637-645.
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A. J. Smith & G. T. Tucker. 1981. Adrenergic Activators and Inhibitors. Adrenergic Activators and Inhibitors 417 504 .
JR Idle, A Mahgoub, MM Angelo, LG Dring, R Lancaster & RL Smith. (2012) The metabolism of [14C]‐debrisoquine in man.. British Journal of Clinical Pharmacology 7:3, pages 257-266.
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