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Xenobiotica
the fate of foreign compounds in biological systems
Volume 6, 1976 - Issue 8
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Original Article

Metronidazole (Flagyl): Degradation by the Intestinal Flora

A. J. F. Searle Department of Biochemistry, Brunei University, Uxbridge, Middlesex, UK
&
R. L. Willson Department of Biochemistry, Brunei University, Uxbridge, Middlesex, UK
Pages 457-464 | Received 12 Nov 1975, Published online: 30 Sep 2009

Citations (19)

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H. P. A. Illing. (1981) Techniques for microfloral and associated metabolic studies in relation to the absorption and enterohepatic circulation of drugs. Xenobiotica 11:12, pages 815-830.
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Articles from other publishers (18)

M. Wlodarska, B. Willing, K. M. Keeney, A. Menendez, K. S. Bergstrom, N. Gill, S. L. Russell, B. A. Vallance & B. B. Finlay. (2011) Antibiotic Treatment Alters the Colonic Mucus Layer and Predisposes the Host to Exacerbated Citrobacter rodentium -Induced Colitis . Infection and Immunity 79:4, pages 1536-1545.
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Kenneth F. Ilett, Lisa B.G. Tee, Philip T. Reeves & Rodney F. Minchin. (1990) Mebolism of drugs and other xenobiotics in the gut lumen and wall. Pharmacology & Therapeutics 46:1, pages 67-93.
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M. J. Kendall. (1989) METOPROLOL—CONTROLLED RELEASE, ZERO ORDER KINETICS. Journal of Clinical Pharmacy and Therapeutics 14:3, pages 159-179.
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R. L. Willson. 1989. Zinc in Human Biology. Zinc in Human Biology 147 172 .
PETER GOLDMAN, RONALD L. KOCH, TIN-CHUEN YEUNG, EWAN J.T. CHRYSTAL, BERNARD B. BEAULIEUJR.JR., MARTHA A. MCLAFFERTY & GILLIAN SUDLOW. 1986. Bioreduction in the Activation of Drugs. Bioreduction in the Activation of Drugs 43 51 .
Peter Goldman, Ronald L. Koch, Tin-Chuen Yeung, Ewan J.T. Chrystal, Bernard B. BeaulieuJr.Jr., Martha A. McLafferty & Gillian Sudlow. (1986) Comparing the reduction of nitroimidazoles in bacteria and mammalian tissues and relating it to biological activity. Biochemical Pharmacology 35:1, pages 43-51.
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C Astier, K Elmorjani, I Meyer, F Joset & M Herdman. (1984) Photosynthetic mutants of the cyanobacteria Synechocystis sp. strains PCC 6714 and PCC 6803: sodium p-hydroxymercuribenzoate as a selective agent. Journal of Bacteriology 158:2, pages 659-664.
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H.R. Rabin & D.L. Lockerby. 1984. Antimicrobial Drug Resistance. Antimicrobial Drug Resistance 317 344 .
Steven B. Neal & Gregory S. Probst. 1984. Sister Chromatid Exchanges. Sister Chromatid Exchanges 613 628 .
Marilyn Olson Robbie & Richard L. Sweet. (1983) Metronidazole use in obstetrics and gynecology: A review. American Journal of Obstetrics and Gynecology 145:7, pages 865-881.
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I.R. Rowland, A. Wise & A.K. Mallett. (1983) Metabolic profile of caecal micro-organisms from rats fed indigestible plant cell-wall components. Food and Chemical Toxicology 21:1, pages 25-29.
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D. E. Schwartz & W. Hofheinz. 1982. Nitroimidazoles. Nitroimidazoles 91 104 .
J. R. Dunlop, J. S. Mahood & R. L. Willson. 1982. Nitroimidazoles. Nitroimidazoles 171 179 .
C.E. Voogd. (1981) On the mutagenicity of nitroimidazoles. Mutation Research/Reviews in Genetic Toxicology 86:3, pages 243-277.
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James A. Guikema & Louis A. Sherman. (1980) Metronidazole and the isolation of temperature-sensitive photosynthetic mutants in cyanobacteria. Journal of Bioenergetics and Biomembranes 12:3-4, pages 277-295.
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Anders Heimdahl, Carl Erik Nord & Katsuji Okuda. (1980) Effect of tinidazole on the oral, throat, and colon microflora of man. Medical Microbiology and Immunology 168:1, pages 1-10.
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Nicholas F. Larusso, Donald G. Lindmark & Miklós Müller. (1978) Biliary and renal excretion, hepatic metabolism, and hepatic subcellular distribution of metronidazole in the rat. Biochemical Pharmacology 27:18, pages 2247-2254.
Crossref
R. L. Willson. 1977. Ciba Foundation Symposium 51 - Iron Metabolism. Ciba Foundation Symposium 51 - Iron Metabolism 331 369 .

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