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Xenobiotica
the fate of foreign compounds in biological systems
Volume 7, 1977 - Issue 6
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Research Article

Reduction of Levopropoxyphene N-Oxide to Propoxy-phene by Dogs in vivo and Rat Liver Microsomal Fraction in vitro

Robert E. McMahon The Lilly Research Laboratories, Indianapolis, Indiana, 46206, USA
&
Hugh R. Sullivan The Lilly Research Laboratories, Indianapolis, Indiana, 46206, USA
Pages 377-382 | Received 26 Aug 1976, Published online: 22 Sep 2008

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T. J. Jaworski, E. M. Hawes, G. McKay & K. K. Midha. (1990) The metabolism of chlorpromazine N-oxide in man and dog. Xenobiotica 20:1, pages 107-115.
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Peter Hlavica & John W. Gorrod. (1982) Biological Oxidation of Nitrogen in Organic Compounds and Disposition of N-Oxidized Product. Critical Reviews in Biochemistry 12:1, pages 39-101.
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N. P. E. Vermeulen, D. D. Breimer, J. Holthuis, C. Mol, B. H. Bakker & A. Van Der Gen. (1981) The metabolic fate of 1′,2′-epoxyhexobarbital in the rat. Xenobiotica 11:8, pages 547-557.
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A. L. Misra, R. B. Pontani & N. L. Vadlamani. (1979) Metabolism of norcocaine, N-hydroxy norcocaine and cocaine-N-oxide in the rat. Xenobiotica 9:3, pages 189-199.
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Articles from other publishers (5)

G. Lin, G. McKay & K.K. Midha. (1996) Characterization of metabolites of clozapine N-oxide in the rat by micro-column high performance liquid chromatography/mass spectrometry with electrospray interface. Journal of Pharmaceutical and Biomedical Analysis 14:11, pages 1561-1577.
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Haiyung Cheng & William J. Jusko. (2006) Pharmacokinetics of reversible metabolic systems. Biopharmaceutics & Drug Disposition 14:9, pages 721-766.
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E. M. Hawes, T. J. Jaworski, K. K. Midha, G. McKay, J. W. Hubbard & E. D. Korchinski. 1991. N-Oxidation of Drugs. N-Oxidation of Drugs 263 286 .
BJÖRN LINDEKE & ARTHUR K. CHO. 1982. Metabolic Basis of Detoxication. Metabolic Basis of Detoxication 105 126 .
S.Y. Yeh, H.A. Krebs & C.W. Gorodetzky. (1979) Isolation and Identification of Morphine N-Oxide α- and β-Dihydromorphines, β- or γ-Isomorphine, and Hydroxylated Morphine as Morphine Metabolites in Several Mammalian Species. Journal of Pharmaceutical Sciences 68:2, pages 133-140.
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