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Xenobiotica
the fate of foreign compounds in biological systems
Volume 7, 1977 - Issue 7
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Research Article

Enzymic Dealkylation of a Substituted Aminoacetamidobenzophenone and Cyclization to the Corresponding Benzodiazepine in vitro

H. P. A. Illing Drug Development, Hoechst Pharmaceutical Research Laboratories, Walton Manor, Walton Milton Keynes, MK7 7AJ, UK
,
M. A. Yeomaxs Drug Development, Hoechst Pharmaceutical Research Laboratories, Walton Manor, Walton Milton Keynes, MK7 7AJ, UK
,
P. A. Rising Drug Development, Hoechst Pharmaceutical Research Laboratories, Walton Manor, Walton Milton Keynes, MK7 7AJ, UK
&
P. Johnson Drug Development, Hoechst Pharmaceutical Research Laboratories, Walton Manor, Walton Milton Keynes, MK7 7AJ, UK
Pages 439-454 | Received 24 Aug 1976, Published online: 22 Sep 2008

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Gábor Maksay & László Ötvös. (1983) Bioactivation of Prodrugs: Structure-Pharmacokinetic Correlations of Benzodiazepine Esters. Drug Metabolism Reviews 14:6, pages 1165-1192.
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H. P. A. Illing, K. V. Watson & J. Chamberlain. (1983) Metabolism of loprazolam in rat- and dog-liver preparations. Xenobiotica 13:9, pages 531-538.
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T. Sato, M. Konishi, T. Ago, Y. Nakagawa, K. Iwatani & Y. Mori. (1980) Metabolism of peptido-aminobenzophenone (2-o-chlorobenzoyl-4-chloro-N-methyl-N′-glycyl-glycinanilide) in dogs. Xenobiotica 10:2, pages 125-133.
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P. A. Rising, H. P. A. Illing, P. Johnson & M. A. Yeomans. (1977) The Metabolism of a Substituted Aminoacetamido-benzophenone and Cyclization to the Corresponding Benzodiazepine in the Rat in vivo. Xenobiotica 7:7, pages 425-437.
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