Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 7, 1977 - Issue 8
21
Views
53
CrossRef citations to date
0
Altmetric
Research Article

Absorption, Excretion and Metabolism of a New Dihydropyridine Diester Cerebral Vasodilator in Rats and Dogs

, , &
Pages 469-479 | Published online: 22 Sep 2008

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (18)

M. Öjzyazici, F. Sevgi & G. Ertan. (1997) Sustained-Release Dosage Form of Nicardipine Hydrochloride: Application of Factorial Design and Effect of Surfactant on Release Kinetics. Drug Development and Industrial Pharmacy 23:8, pages 761-770.
Read now
H. Nakabeppu, M. Asada, T. Oda, Y. Shinozaki & T. Yajima. (1996) Plasma and urinary metabolites of efonidipine hydrochloride in man. Xenobiotica 26:2, pages 229-239.
Read now
T. Teramura, T. Tokunaga, H. Matsumoto, T. Watanabe & S. Higuchi. (1996) Metabolism of barnidipine hydrochloride, a potent calcium antagonist, in rat and dog. Xenobiotica 26:2, pages 177-187.
Read now
N. Ogawa, K. Mizuno, K. Fukushima, T. Suwa & T. Satoh. (1993) Metabolic fate of a new dihydropyridine calcium antagonist, CD-349, in rat and dog. Xenobiotica 23:7, pages 747-759.
Read now
P. Grossi, M. Pellegatti, G. Vigelli, J. Ayrton, B. A. Duncan & J. Maltas. (1992) Lacidipine metabolism in rat and dog: identification and synthesis of main metabolites. Xenobiotica 22:8, pages 899-916.
Read now
M. Pellegatti, P. Grossi, J. Ayrton, G. L. Evans & A. J. Harker. (1990) Absorption, distribution and excretion of lacidipine, a dihydropyridine calcium antagonist, in rat and dog. Xenobiotica 20:8, pages 765-777.
Read now
F. Takayama, Y. Iwasawa, K. Saito, K. Shiratori & M. Ohtawa. (1989) Metabolism of a new dihydropyridine calcium antagonist in rats and dogs. Xenobiotica 19:12, pages 1407-1420.
Read now
S. Terashita, Y. Tokuma, M. Sekiguchi & H. Noguchi. (1989) Sex differences in the metabolism and excretion of nilvadipine, a new dihydropyridine calcium antagonist, in rats. Xenobiotica 19:11, pages 1221-1229.
Read now
G. C. Visor, B. Schuessler, J. Thompson & T. Ling. (1987) Nasal Absorption of the Calcium Antagonist Nicardipine in Rats and Rhesus Monkeys. Drug Development and Industrial Pharmacy 13:8, pages 1329-1343.
Read now
S. Terashita, Y. Tokuma, T. Fujiwara, Y. Shiokawa, K. Okumura & H. Noguchi. (1987) Metabolism of nilvadipine, a new dihydropyridine calcium antagonist, in rats and dogs. Xenobiotica 17:12, pages 1415-1425.
Read now
W. R. Rush, O. Alexander, D. J. Hall, L. Cairncross, R. J. Dow & D. J. G. Graham. (1986) The metabolism of nicardipine hydrochloride in healthy male volunteers. Xenobiotica 16:4, pages 341-349.
Read now
I. Midgley, L. F. Chasseaud, I. W. Taylor, L. M. Walmsley, A. G. Fowkes, A. Darragh, R. F. Lambe & R. Bonn. (1985) Metabolism and pharmacokinetics of the dihydropyridine calcium antagonist, ryosidine, in man. Xenobiotica 15:11, pages 965-977.
Read now
C. Bäärnhielm, I. Skånberg & K. O. Borg. (1984) Cytochrome P-450-dependent oxidation of felodipine—a 1,4-dihydropyridine—to the corresponding pyridine. Xenobiotica 14:9, pages 719-726.
Read now
L. Weidolf, K. O. Borg & K. J. Hoffmann. (1984) Urinary metabolites of felodipine, a new vasodilator drug, in man, dog, rat and mouse. Xenobiotica 14:8, pages 657-666.
Read now
S. Higuchi & Y. Shiobara. (1980) Metabolic fate of nicardipine hydrochloride, a new vasodilator, by various species in vitro. Xenobiotica 10:12, pages 889-896.
Read now

Articles from other publishers (35)

Liang Li. 2014. Handbook of Metabolic Pathways of Xenobiotics. Handbook of Metabolic Pathways of Xenobiotics 1 4 .
Junko Mizumura, Nobutoshi Watari & Shigesada Higuchi. (1998) Possibility of Partial Absorption of Nicardipine by Routes Other Than the Hepato-portal System After Oral Administration in Rats. Journal of Pharmacy and Pharmacology 50:7, pages 775-781.
Crossref
Naoe Yamane, Tomonori Takami, Zenzaburo Tozuka, Yuichi Sugiyama, Akira Yamazaki & Yuji Kumagai. (2009) Microdose Clinical Trial: Quantitative Determination of Nicardipine and Prediction of Metabolites in Human Plasma. Drug Metabolism and Pharmacokinetics 24:4, pages 389-403.
Crossref
Nobuyuki Tanaka, Keiji Imai, Kazuto Okimoto, Satoshi Ueda, Yuji Tokunaga, Rinta Ibuki, Kazutaka Higaki & Toshikiro Kimura. (2006) Development of novel sustained-release system, disintegration-controlled matrix tablet (DCMT) with solid dispersion granules of nilvadipine (II): In vivo evaluation. Journal of Controlled Release 112:1, pages 51-56.
Crossref
Yumi Ohtake, Takashi Sakamoto, Ryota Nishioka, Kazuo Uno & Shigeru Tabata. (2012) Metabolic Fate of Felodipine in Man. Drug Investigation 4:6, pages 528-534.
Crossref
Fiorenzo Dagani, Rosaria Ferrari, Pietro Tosca & Laura Canevari. (1992) Effects of calcium antagonists on glycolysis of rat brain synaptosomes. Biochemical Pharmacology 43:2, pages 371-374.
Crossref
JH Ahmed, AC Grant, RS Rodger, GR Murray & HL Elliott. (2012) Inhibitory effect of uraemia on the hepatic clearance and metabolism of nicardipine.. British Journal of Clinical Pharmacology 32:1, pages 57-62.
Crossref
Howard Parnes & Glenn T. Huan. (1991) Synthesis of high specific activity tritiated dihydropyridines: Nicardipine-3H. Journal of Labelled Compounds and Radiopharmaceuticals 29:1, pages 87-93.
Crossref
P. O. Greiner, S. Weber, J. Angignard & B. Berbey. (1990) Evaluation of first pass effect and biliary excretion of diperdipine in the dog. European Journal of Drug Metabolism and Pharmacokinetics 15:3, pages 185-190.
Crossref
Fredric B. Meyer, Robert E. Anderson & Thoralf M. SundtJr.Jr.. (2007) Anticonvulsant Effects of Dihydropyridine Ca 2+ Antagonists in Electrocortical Shock Seizures . Epilepsia 31:1, pages 68-74.
Crossref
Bramah N. Singh & Martin A. Josephson. (1990) Clinical pharmacology, pharmacokinetics, and hemodynamic effects of nicardipine. American Heart Journal 119:2, pages 427-434.
Crossref
Nobutoshi Watari, Junko Mizumura & Shigesada Higuchi. (1990) Simultanous microdetermination of nicardipine and its pyridine metabolite in body fluids by capillary column gas chromatography with electron-capture detection. Journal of Chromatography B: Biomedical Sciences and Applications 530, pages 438-446.
Crossref
Kenji Morishima, Ritsuko Tahara & Masato Horiuchi. (1990) Determination of a new calcium antagonist, sesamodil fumarate (SD-3211), and its metabolite in plasma by liquid chromatography with electrochemical detection. Journal of Chromatography B: Biomedical Sciences and Applications 527, pages 381-388.
Crossref
Jerry J. Zimmerman, Susan M. Zuk & June R. Millard. (1989) In vitro modulation of human neutrophil superoxide anion generation by various calcium channel antagonists used in ischemia-reperfusion resuscitation. Biochemical Pharmacology 38:20, pages 3601-3610.
Crossref
Howard Parnes, Glenn T. Huang & Emma J. Shelton. (2006) Synthesis of [ 14 C]‐labelled dihydropyridine calcium channel entry blockers: Nicardipine‐[4‐ 14 C] and RS‐93522‐[4‐ 14 C] . Journal of Labelled Compounds and Radiopharmaceuticals 25:6, pages 621-626.
Crossref
J. C. Delchier, M. Guerret, N. Vidon, C. Dubray & D. Lavene. (1988) Influence of digestive secretions and food on intestinal absorption of nicardipine. European Journal of Clinical Pharmacology 34:2, pages 165-171.
Crossref
F. B. Meyer, R. E. Anderson & T. M. Sundt. 1988. The Calcium Channel: Structure, Function and Implications. The Calcium Channel: Structure, Function and Implications 503 519 .
A. G. Odynets, V. Ya. Parinov, A. A. Kimenis & G. Ya. Dubur. (1987) Study of the biotransformation of 1,4-dihydropyridines in experiments in vitro. Pharmaceutical Chemistry Journal 21:8, pages 551-554.
Crossref
James C. Grotta, L. Creed Pettigrew, Alan H. Lockwood & Catherine Reich. (2004) Brain extraction of a calcium channel blocker. Annals of Neurology 21:2, pages 171-175.
Crossref
Shin-Ichiro Kobayashi. (1987) Simple method for the determination of nicardipine in plasma using high-performance liquid chromatography. Journal of Chromatography B: Biomedical Sciences and Applications 420, pages 439-444.
Crossref
STANLEY M. LEE, ROGER WILLIAMS, DAVID WARNOCK, MICHAEL EMMETT & ROBERT A. WOLBACH. (1986) The effects of nicardipine in hypertensive subjects with impaired renal function. British Journal of Clinical Pharmacology 22, pages 297S-306S.
Crossref
R. J. DOW & D. J. M. GRAHAM. (1986) A review of the human metabolism and pharmacokinetics of nicardipine hydrochloride. British Journal of Clinical Pharmacology 22, pages 195S-202S.
Crossref
J Grotta, J Spydell, C Pettigrew, P Ostrow & D Hunter. (1986) The effect of nicardipine on neuronal function following ischemia.. Stroke 17:2, pages 213-219.
Crossref
B. Silke, D. J. M. Graham, S. P. Verma, G. Reynolds, M. A. Frais, J. R. Finlayson & S. H. Taylor. (1986) Pharmacokinetic, haemodynamic and radionuclide studies with nicardipine in coronary artery disease. European Journal of Clinical Pharmacology 29:6, pages 651-657.
Crossref
G.C. Visor, E. Bajka & E. Benjamin. (1986) Intranasal Delivery of Nicardipine in the Rat. Journal of Pharmaceutical Sciences 75:1, pages 44-46.
Crossref
Kurt-J. Hoffmann & Lars Weidolf. (1985) Identification of felodipine metabolites in rat urine. Biological Mass Spectrometry 12:8, pages 414-423.
Crossref
Martin Ahnoff, Magnar Ervik, Per-Olof Lagerström, Bengt-Arne Persson & Jörgen Vessman. (1985) Drug level monitoring: cardiovascular drugs. Journal of Chromatography B: Biomedical Sciences and Applications 340, pages 73-138.
Crossref
Sherrin H. Baky. (2007) Nicardipine Hydrochloride. Cardiovascular Drug Reviews 3:1, pages 153-172.
Crossref
BJ Alps, C. Calder & A. Wilson. (2012) Nicardipine in models of myocardial infarction.. British Journal of Clinical Pharmacology 20:S1.
Crossref
DJ Graham, RJ Dow, DJ Hall, OF Alexander, EJ Mroszczak & D. Freedman. (2012) The metabolism and pharmacokinetics of nicardipine hydrochloride in man.. British Journal of Clinical Pharmacology 20:S1.
Crossref
P.R. Ortiz de Montellano, H.S. Beilan & K.L. Kunze. (1981) N-Alkylprotoporphyrin IX formation in 3,5-dicarbethoxy-1,4-dihydrocollidine-treated rats. Transfer of the alkyl group from the substrate to the porphyrin.. Journal of Biological Chemistry 256:13, pages 6708-6713.
Crossref
S. Higuchi & S. Kawamura. (1981) Specific determination of plasma nicardipine hydrochloride levels by gas chromatography—mass spectrometry. Journal of Chromatography B: Biomedical Sciences and Applications 223:2, pages 341-349.
Crossref
S. Higuchi & Y. Shiobara. (1980) Application of the stable isotope technique to the elucidation of the saturation phenomenon of nicardipine hydrochloride metabolizing enzyme activity in dogs. Biological Mass Spectrometry 7:8, pages 339-344.
Crossref
W. Lesley Matier & William T. Comer. 1978. 71 81 .
Nobuo Sakamoto, Michio Terai, Toichi Takenaka & Hiroo Maeno. (1978) Inhibition of cyclic amp phosphodiesterase by 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-[2-(N-benzyl-N-methylamino)] ethyl ester 5-methyl ester hydrochloride (YC-93), a potent vasodilator. Biochemical Pharmacology 27:8, pages 1269-1274.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.