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Xenobiotica
the fate of foreign compounds in biological systems
Volume 7, 1977 - Issue 1-2
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Research Article

Inhibition of 1,2-Dimethylhydrazine Metabolism by Disulfiram

E. S. Fiala Naylor Dana Institute for Disease Prevention, American Health Foundation, Valhalla, New York, 10595, USA
,
G. Bobotas Naylor Dana Institute for Disease Prevention, American Health Foundation, Valhalla, New York, 10595, USA
,
C. Kulakis Naylor Dana Institute for Disease Prevention, American Health Foundation, Valhalla, New York, 10595, USA
&
J. H. Weisburger Naylor Dana Institute for Disease Prevention, American Health Foundation, Valhalla, New York, 10595, USA
Pages 5-9 | Received 27 Feb 1976, Published online: 22 Sep 2008

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Thomas J. Haley. (1979) Disulfiram (Tetraethylthioperoxydicarbonic Diamide): A Reappraisal of Its Toxicity and Therapeutic Application. Drug Metabolism Reviews 9:2, pages 319-335.
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Articles from other publishers (19)

Zvi RappoportDerek V. Banthorpe. 2010. Patai's Chemistry of Functional Groups. Patai's Chemistry of Functional Groups.
Gregory P. Boivin, Kay Washington, Kan Yang, Jerrold M. Ward, Theresa P. Pretlow, Robert Russell, David G. Besselsen, Virginia L. Godfrey, Tom Doetschman, William F. Dove, Henry C. Pitot, Richard B. Halberg, Steven H. Itzkowitz, Joanna Groden & Robert J. Coffey. (2003) Pathology of mouse models of intestinal cancer: Consensus report and recommendations. Gastroenterology 124:3, pages 762-777.
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Joe M. Angel, Natasha Popova, N. Lanko, Vladimir S. Turusov & John DiGiovanni. (2000) A locus that influences susceptibility to 1,2-dimethylhydrazine-induced colon tumors maps to the distal end of mouse chromosome 3. Molecular Carcinogenesis 27:1, pages 47-54.
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Timothy F. McMahon, Michael L. Cunningham & M. J. Prival. (2006) Mutagenicity of methylazoxymethanol acetate in the presence of alcohol dehydrogenase, aldehyde dehydrogenase, and rat liver microsomes in Salmonella typhimurium his G46 . Environmental and Molecular Mutagenesis 18:3, pages 151-156.
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Tomáš Gichner & Jiří Velemínský. (1988) Mechanisms of inhibition of N-nitroso compounds-induced mutagenicity. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 202:2, pages 325-334.
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T. Gichner, J. Velemínský & R. Rieger. (1988) Antimutagenic effects of diethyldithiocarbamate towards maleic hydrazide- and N-nitrosodiethylamine-induced mutagenicity in theTradescantia mutagenicity assay. Biologia Plantarum 30:1, pages 14-19.
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D.E. Hathway. 1986. Mechanisms of Chemical Carcinogenesis. Mechanisms of Chemical Carcinogenesis 85 99 .
T. Gichner & Jiři Velemínský. (1984) Inhibition of dimethylnitrosamine-induced mutagenesis in Arabidopsis thaliana by diethyldithiocarbamate and carbon monoxide. Mutation Research Letters 139:1, pages 29-33.
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S. Wolter & N. Frank. (1982) Metabolism of 1,2-dimethylhydrazine in isolated perfused rat liver. Chemico-Biological Interactions 42:3, pages 335-344.
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I.R. Rowland, B.G. Lake, J.C. Phillips & S.D. Gangolli. (1980) Substrates and inhibitors of hepatic amine oxidase inhibit dimethylnitrosamine-induced mutagenesis in Salmonella typhimurium. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 72:1, pages 63-72.
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Richard C. Cottrell, Phillip J. Young, David G. Walters, John C. Phillips, Brian G. Lake & Sharat D. Gangolli. (1979) Studies of the metabolism of N-nitrosopyrrolidine in the rat. Toxicology and Applied Pharmacology 51:1, pages 101-106.
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Carol M. Schiller, Ramsey Walden & Thomas E. KeeJr.Jr.. (1979) Effects of hydrazine and its derivatives on the development of intestinal brush border enzymes. Toxicology and Applied Pharmacology 49:2, pages 305-311.
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J.Thomas LaMont & Thomas A. O'Gorman. (1978) Experimental colon cancer. Gastroenterology 75:6, pages 1157-1169.
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Anthony E. Pegg. (1978) Inhibition of the alkylation of nucleic acids and of the metabolism of 1,2-dimethylhydrazine by aminoacetonitrile. Chemico-Biological Interactions 23:2, pages 273-279.
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Norman D. Nigro & Robert L. Campbell. (1978) Inhibition of azoxymethane-induced intestinal cancer by disulfiram. Cancer Letters 5:2, pages 91-95.
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Emerich S. Fiala. (1977) Investigations into the metabolism and mode of action of the colon carcinogens 1,2-dimethylhydrazine and azoxymethane. Cancer 40:S5, pages 2436-2445.
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Emerich S. Fiala, George Bobotas, Callie Kulakis, Lee W. Wattenberg & John H. Weisburger. (1977) Effects of disulfiram and related compounds on the metabolism in vivo of the colon carcinogen, 1,2-dimethylhydrazine. Biochemical Pharmacology 26:19, pages 1763-1768.
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Herman Autrup, Curtis C. Harris, Steven Fugaro & James K. Selkirk. (1977) Effect of various chemicals on the metabolism of benzo(a)pyrene by cultured rat colon. Chemico-Biological Interactions 18:3, pages 337-347.
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