Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 7, 1977 - Issue 3
60
Views
33
CrossRef citations to date
0
Altmetric
Original Article

Epoxidation of the Stilbene Double Bond, a Major Pathway in Aminostilbene Metabolism

&
Pages 117-132 | Received 29 Apr 1976, Published online: 30 Sep 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Jun Abe, Yoshitaka Tomigahara, Hirokazu Tarui, Hirohisa Nagahori, Motohiro Kurosawa, Kenji Sugimoto & Naohiko Isobe. (2018) Metabolism of metofluthrin in rats: II. Excretion, distribution and amount of metabolites. Xenobiotica 48:11, pages 1113-1127.
Read now
Jun Abe, Hirohisa Nagahori, Hirokazu Tarui, Yoshitaka Tomigahara & Naohiko Isobe. (2018) Metabolism of metofluthrin in rats: I. Identification of metabolites. Xenobiotica 48:2, pages 157-169.
Read now
K.-J. Hoffmann, A. Arfwidsson, K. O. Borg & I. Skånberg. (1979) Identification of Urinary and Biliary Metabolites of Alprenolol in the Rat. Xenobiotica 9:2, pages 93-106.
Read now

Articles from other publishers (29)

Asim A. Balakit, Rajab Abu-El-Halawa, Ali H. Alsadoon, Rana A. Ghaleb, Sanad Alfadhel, Nabel B. Ayrim & Elaf S. Alsultan. (2023) Synthesis, Antiproliferative, and Molecular Docking Studies of 3-Mercapto-1,2,4-Triazole Derivatives as Combretastatin A-4 Analogs. Pharmaceutical Chemistry Journal.
Crossref
Momen R. Fareed, Mai E. Shoman, Mohammed I. A. Hamed, Mohamed Badr, Hanin A. Bogari, Sameh S. Elhady, Tarek S. Ibrahim, Gamal El-Din A. Abuo-Rahma & Taha F. S. Ali. (2021) New Multi-Targeted Antiproliferative Agents: Design and Synthesis of IC261-Based Oxindoles as Potential Tubulin, CK1 and EGFR Inhibitors. Pharmaceuticals 14:11, pages 1114.
Crossref
Roberto Romeo, Salvatore V. Giofrè, Maria A. Chiacchio, Lucia Veltri, Consuelo Celesti & Daniela Iannazzo. (2021) Synthesis and Biological Evaluation of 2,3,4-Triaryl-1,2,4-oxadiazol-5-ones as p38 MAPK Inhibitors. Molecules 26:6, pages 1745.
Crossref
Muhamad Mustafa, Sirajudheen Anwar, Firgani Elgamal, Esam R. Ahmed & Omar M. Aly. (2019) Potent combretastatin A-4 analogs containing 1,2,4-triazole: Synthesis, antiproliferative, anti-tubulin activity, and docking study. European Journal of Medicinal Chemistry 183, pages 111697.
Crossref
Kishore Mullagiri, V. Lakshma Nayak, Satish Sunkari, Geeta Sai Mani, Sravanthi Devi Guggilapu, Burri Nagaraju, Abdullah Alarifi & Ahmed Kamal. (2018) New (3-(1 H -benzo[ d ]imidazol-2-yl))/(3-(3 H -imidazo[4,5- b ]pyridin-2-yl))-(1 H -indol-5-yl)(3,4,5-trimethoxyphenyl)methanone conjugates as tubulin polymerization inhibitors . MedChemComm 9:2, pages 275-281.
Crossref
A.V. Subba Rao, Konderu Swapna, Siddiq Pasha Shaik, V. Lakshma Nayak, T. Srinivasa Reddy, Satish Sunkari, Thokhir Basha Shaik, Chandrakant Bagul & Ahmed Kamal. (2017) Synthesis and biological evaluation of cis -restricted triazole/tetrazole mimics of combretastatin-benzothiazole hybrids as tubulin polymerization inhibitors and apoptosis inducers. Bioorganic & Medicinal Chemistry 25:3, pages 977-999.
Crossref
Md. Ashraf, Thokhir B. Shaik, M. Shaheer Malik, Riyaz Syed, Prema L. Mallipeddi, M.V.P.S. Vishnu Vardhan & Ahmed Kamal. (2016) Design and synthesis of cis-restricted benzimidazole and benzothiazole mimics of combretastatin A-4 as antimitotic agents with apoptosis inducing ability. Bioorganic & Medicinal Chemistry Letters 26:18, pages 4527-4535.
Crossref
Germano Castelli, Federica Bruno, Fabrizio Vitale, Marinella Roberti, Claudia Colomba, Elisa Giacomini, Laura Guidotti, Antonio Cascio & Manlio Tolomeo. (2016) In vitro antileishmanial activity of trans-stilbene and terphenyl compounds. Experimental Parasitology 166, pages 1-9.
Crossref
Rossella Fioravanti, Ignacio Celestino, Roberta Costi, Giuliana Cuzzucoli Crucitti, Luca Pescatori, Leonardo Mattiello, Ettore Novellino, Paola Checconi, Anna Teresa Palamara, Lucia Nencioni & Roberto Di Santo. (2012) Effects of polyphenol compounds on influenza A virus replication and definition of their mechanism of action. Bioorganic & Medicinal Chemistry 20:16, pages 5046-5052.
Crossref
Simone Bertini, Vincenzo Calderone, Isabella Carboni, Roberta Maffei, Alma Martelli, Adriano Martinelli, Filippo Minutolo, Mehdi Rajabi, Lara Testai, Tiziano Tuccinardi, Riccardo Ghidoni & Marco Macchia. (2010) Synthesis of heterocycle-based analogs of resveratrol and their antitumor and vasorelaxing properties. Bioorganic & Medicinal Chemistry 18:18, pages 6715-6724.
Crossref
Gian Cesare Tron, Tracey Pirali, Giovanni Sorba, Francesca Pagliai, Sara Busacca & Armando A. Genazzani. (2006) Medicinal Chemistry of Combretastatin A4:  Present and Future Directions. Journal of Medicinal Chemistry 49:11, pages 3033-3044.
Crossref
Marinella Roberti, Daniela Pizzirani, Maurizio Recanatini, Daniele Simoni, Stefania Grimaudo, Di Cristina, Vincenzo Abbadessa, Nicola Gebbia & Manlio Tolomeo. (2006) Identification of a Terphenyl Derivative that Blocks the Cell Cycle in the G 0 −G 1 Phase and Induces Differentiation in Leukemia Cells . Journal of Medicinal Chemistry 49:10, pages 3012-3018.
Crossref
Filippo Minutolo, Giusy Sala, Annalisa Bagnacani, Simone Bertini, Isabella Carboni, Giorgio Placanica, Giovanni Prota, Simona Rapposelli, Nicoletta Sacchi, Marco Macchia & Riccardo Ghidoni. (2005) Synthesis of a Resveratrol Analogue with High Ceramide-Mediated Proapoptotic Activity on Human Breast Cancer Cells. Journal of Medicinal Chemistry 48:22, pages 6783-6786.
Crossref
M. Wildschütte, R. Franz & H.-G. Neumann. (1990) The tentative identification of DNA-adducts generated by trans-4-dimethylaminostilbene and trans-4-acetylaminostilbene in rats. Chemico-Biological Interactions 76:1, pages 47-62.
Crossref
R. Franz & H.-G. Neumann. (1987) Reaction of trans-4-N-acetoxy-N-acetylaminostilbene with guanosine, deoxyguanosine, RNA and DNA in vitro: predominant product is a cyclic N2,N3-guanine adduct. Chemico-Biological Interactions 62:2, pages 143-155.
Crossref
R. Franz, H.-R. Schulten & H.-G. Neumann. (1986) Identification of nucleic acid adducts from trans-4acetylaminostilbene. Chemico-Biological Interactions 59, pages 281-293.
Crossref
Peter H. Jellinck, Jane Løvsted & Anne-Marie Newcombe. (1983) Oxidation of [14C]diethylstilbestrol epoxide by uterine peroxidase: a possible protective mechanism. Biochemical Pharmacology 32:21, pages 3247-3249.
Crossref
P. J. G. Cornelissen. (1981) Fotochemische en fotobiologische activiteit van enige 1,4-benzodiazepinen. Pharmaceutisch weekblad 3:1, pages 1205-1211.
Crossref
M. Metzler. (1981) Studies on the mechanism of carcinogenicity of diethylstilboestrol: Role of metabolic activation. Food and Cosmetics Toxicology 19, pages 611-615.
Crossref
P. J. G. Cornelissen & G. M. J. Beijersbergen van Henegouwen. (1980) Photochemical decomposition of 1,4-benzodiazepines. Pharmaceutisch Weekblad Scientific Edition 2:1, pages 547-556.
Crossref
B.J.M. Gaugler, H.-G. Neumann, Norma K. Scribner & J.D. Scribner. (1979) Identification of some products from the reaction of trans-4-aminostilbene metabolites and nucleic acids in vivo. Chemico-Biological Interactions 27:2-3, pages 335-342.
Crossref
Norma K. Scribner, John D. Scribner, David L. Smith, Karl H. Schram & James A. Mccloskey. (1979) Reactions of the carcinogen N-acetoxy-4-acetamidostilbene with nucleosides. Chemico-Biological Interactions 26:1, pages 27-46.
Crossref
Bernhard J.M. Gaugler & Hans-Gunter Neumann. (1979) The binding of metabolites formed from aminostilbene derivatives to nucleic acids in the liver of rats. Chemico-Biological Interactions 24:3, pages 355-372.
Crossref
L.F. Chasseaud. 1979. 175 274 .
Hans-Günter Neumann & Manfred Metzler. 1979. Toxicology. Toxicology 113 122 .
Gisela H. Degen & Hans-Günter Neumann. (1978) The major metabolite of aflatoxin B1 in the rat is a glutathione conjugate. Chemico-Biological Interactions 22:2-3, pages 239-255.
Crossref
M.S.F. Ross, D.S. Lines, K.R. Brain & R.G. Stevens. (1978) Monooxygenase and epoxide hydratase analysis by high-performance liquid chromatography. Analytical Biochemistry 87:1, pages 267-271.
Crossref
E. Wieland & H. -G. Neumann. (1978) Methemoglobin formation and binding to blood constituents as indicators for the formation, availability and reactivity of activated metabolites derived from trans-4-aminostilbene and related aromatic amines. Archives of Toxicology 40:1, pages 17-35.
Crossref
H. -G. Neumann, M. Metzler & W. T�pner. (1977) Metabolic activation of diethylstilbestrol and aminostilbene-derivatives. Archives of Toxicology 39-39:1-2, pages 21-30.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.