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Xenobiotica
the fate of foreign compounds in biological systems
Volume 7, 1977 - Issue 10
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Research Article

Spironolactone: Diversity in Metabolic Pathways

A. Karim Searle Laboratories, P.O. Box 5110, Chicago, Illinois, 60680, USA
,
J. Hribar Searle Laboratories, P.O. Box 5110, Chicago, Illinois, 60680, USA
,
M. Doherty Searle Laboratories, P.O. Box 5110, Chicago, Illinois, 60680, USA
,
W. Aksamit Searle Laboratories, P.O. Box 5110, Chicago, Illinois, 60680, USA
,
D. Chappelow Searle Laboratories, P.O. Box 5110, Chicago, Illinois, 60680, USA
,
E. Brown Searle Laboratories, P.O. Box 5110, Chicago, Illinois, 60680, USA
,
C. Markos Searle Laboratories, P.O. Box 5110, Chicago, Illinois, 60680, USA
,
L. J. Chinn Searle Laboratories, P.O. Box 5110, Chicago, Illinois, 60680, USA
,
D. Liang Searle Laboratories, P.O. Box 5110, Chicago, Illinois, 60680, USA
&
J. Zagarella Searle Laboratories, P.O. Box 5110, Chicago, Illinois, 60680, USA
 show all
Pages 585-600 | Received 08 Nov 1976, Published online: 22 Sep 2008

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F.W H.M. Merkus, J.W. P.M. Overdiek, J. Cilissen & J. Zuidema. (1983) Pharmacokinetics of Spironolactone After a Single Dose: Evaluation of the true Canrenone Serum Concentrations During 24 Hours. Clinical and Experimental Hypertension. Part A: Theory and Practice 5:2, pages 239-248.
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Aziz Karim. (1978) Spironolactone: Disposition, Metabolism, Pharmacodynamics, and Bioavailability. Drug Metabolism Reviews 8:1, pages 151-188.
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Articles from other publishers (18)

J.M. Sandall, J.S. Millership, P.S. Collier & J.C. McElnay. (2006) Development and validation of an HPLC method for the determination of spironolactone and its metabolites in paediatric plasma samples. Journal of Chromatography B 839:1-2, pages 36-44.
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Evanthia Diamanti-Kandarakis, George Tolis & Antoni J. Duleba. (2016) Androgens and Therapeutic Aspects of Antiandrogens in Women. Journal of the Society for Gynecologic Investigation 2:4, pages 577-592.
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W. Möhrke & F. Ullrich. 1995. Diuretics. Diuretics 173 200 .
J. Elks & C. R. Ganellin. 1990. Dictionary of Drugs. Dictionary of Drugs 1086 1144 .
Charles S. Markos, Clifford R. Dorn & Donald J. Zitzewitz. (2006) Synthesis of canrenone and related steroids labelled with tritium, carbon‐14, and sulfur‐35. Journal of Labelled Compounds and Radiopharmaceuticals 25:5, pages 515-529.
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N.Lynn Flowers, James H. Sherry, John P. O'donnell & Howard D. Colby. (1988) Adrenal mitochondrial metabolism of spironolactone. Biochemical Pharmacology 37:8, pages 1591-1595.
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H.W.P.M. Overdiek & F.W.H.M. Merkus. (1987) THE METABOLISM AND BIOPHARMACEUTICS OF SPIRONOLACTONE IN MAN. Drug Metabolism and Drug Interactions 5:4, pages 273-302.
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James H. Sherry, John P. O'Donnell & Howard D. Colby. (1986) Separation of spironolactone and its biologically active sulfur-containing metabolites by high-performance liquid chromatography. Journal of Chromatography B: Biomedical Sciences and Applications 374, pages 183-190.
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J.W.P.M. Overdiek, W.A.J.J. Hermens & F.W.H.M. Merkus. (1985) Determination of the serum concentration of spironolactone and its metabolites by high-performance liquid chromatography. Journal of Chromatography B: Biomedical Sciences and Applications 341, pages 279-285.
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D. Platt, U. Abshagen, W. Mühlberg, H.-J. Horn, R. Schmitt-Rüth & J. Vollmar. (1984) The influence of age and multimorbidity on the pharmacokinetics and metabolism of spironolactone. Archives of Gerontology and Geriatrics 3:2, pages 147-159.
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D.J. Tindall, C.H. Chang, T.J. Lobl & G.R. Cunningham. (1984) Androgen antagonists in androgen target tissues. Pharmacology & Therapeutics 24:3, pages 367-400.
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U. Weissenborn & H.C. Erbler. (1983) Metabolism of spirolactones by the rat testis in vitro. Steroids 42:4, pages 365-388.
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James H. Sherry, John P. O'Donnell & Howard D. Colby. (1981) Conversion of spironolactone to an active metabolite in target tissues: formation of 7α-thiospironolactone by microsomal preparations from guinea pig liver, adrenals, kidneys, and testes. Life Sciences 29:26, pages 2727-2736.
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D. R. Boreham, C. W. Vose, V. Balasubramanian & C. J. W. Brooks. (2005) Gas chromatography mass spectrometry of some steroidal spirolactones. Organic Mass Spectrometry 14:8, pages 442-447.
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R.H. Menard, T.M. Guenthner, H. Kon & J.R. Gillette. (1979) Studies on the destruction of adrenal and testicular cytochrome P-450 by spironolactone. Requirement for the 7alpha-thio group and evidence for the loss of the heme and apoproteins of cytochrome P-450.. Journal of Biological Chemistry 254:5, pages 1726-1733.
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Harkishan Singh, Vijay K. Kapoor & Dharam Paul. 1979. 35 149 .
U. Abshagen, E. Besenfelder, R. Endele, K. Koch & B. Neubert. (1979) Kinetics of canrenone after single and multiple doses of spironolactone. European Journal of Clinical Pharmacology 16:4, pages 255-262.
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Raymond H. Menard, D. Lynn Loriaux, Frederic C. Bartter & James R. Gillette. (1978) The effect of the administration of spironolactone on the concentration of plasma testosterone, estradiol and cortisol in male dogs. Steroids 31:6, pages 771-782.
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