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Xenobiotica
the fate of foreign compounds in biological systems
Volume 8, 1978 - Issue 8
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Original Article

Absorption of the β-Adrenergic-Blocking Agent, Nadolol, by Mice, Rats, Hamsters, Rabbits, Dogs, Monkeys, and Man: An Unusual Species Difference

Jacques Dreyfuss Department of Drug Metabolism, Division of Drug Safety Evaluation, The Squibb Institute for Medical Research, New Brunswick, New Jersey, 08903, USA
,
James M. Shaw Department of Drug Metabolism, Division of Drug Safety Evaluation, The Squibb Institute for Medical Research, New Brunswick, New Jersey, 08903, USA
&
John J. Ross Department of Drug Metabolism, Division of Drug Safety Evaluation, The Squibb Institute for Medical Research, New Brunswick, New Jersey, 08903, USA
Pages 503-508 | Received 16 Jul 1977, Published online: 30 Sep 2009

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S. Sakuda, T. Akabane & T. Teramura. (2006) Marked species differences in the bioavailability of midazolam in cynomolgus monkeys and humans. Xenobiotica 36:4, pages 331-340.
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Bruce Clark, Dennis A. Smith & John Caldwell. (1984) Pharmacokinetics and Toxicity Testing. CRC Critical Reviews in Toxicology 12:4, pages 343-385.
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Edward J. Calabrese. (1984) Gastrointestinal and Dermal Absorption: Interspecies Differences. Drug Metabolism Reviews 15:5-6, pages 1013-1032.
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A. A. Schiff & Alison Saxey. (1984) Autoradiography of nadolol and propranolol in the rat. Xenobiotica 14:9, pages 687-691.
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Articles from other publishers (21)

Safiyya Zaidi, Fatin Atrooz, Daniel Valdez, Hesong Liu, Camila Kochi, Richard A. Bond & Samina Salim. (2020) Protective effect of propranolol and nadolol on social defeat-induced behavioral impairments in rats. Neuroscience Letters 725, pages 134892.
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Karl K. Rozman, John Doull & Wayland J. HayesJr.Jr.. 2010. Hayes' Handbook of Pesticide Toxicology. Hayes' Handbook of Pesticide Toxicology 3 101 .
Amin A. Nomeir, Richard Morrison, Daniel Prelusky, Walter Korfmacher, Lisa Broske, David Hesk, Paul McNamara & Hong Mei. (2009) Estimation of the extent of oral absorption in animals from oral and intravenous pharmacokinetic data in drug discovery. Journal of Pharmaceutical Sciences 98:11, pages 4027-4038.
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David L. Pole. (2008) Physical and biological considerations for the use of nonaqueous solvents in oral bioavailability enhancement. Journal of Pharmaceutical Sciences 97:3, pages 1071-1088.
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Marc-Etienne Castella, Marianne Reist, Joachim M. Mayer, Jean-Jacques Turban, Bernard Testa, Claire Boursier-Neyret, Bernard Walther, Jean-Marie Delbos & Pierre-Alain Carrupt. (2006) Development of an in Vitro Rat Intestine Segmental Perfusion Model to Investigate Permeability and Predict Oral Fraction Absorbed. Pharmaceutical Research 23:7, pages 1543-1553.
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Ichiro Morioka, Ronald J Wong, Aida Abate, Hendrik J Vreman, Christopher H Contag & David K Stevenson. (2006) Systemic Effects of Orally-Administered Zinc and Tin (IV) Metalloporphyrins on Heme Oxygenase Expression in Mice. Pediatric Research 59:5, pages 667-672.
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Yuan H Zhao, Michael H Abraham, Joelle Le, Anne Hersey, Chris N Luscombe, Gordon Beck, Brad Sherborne & Ian Cooper. (2003) Evaluation of rat intestinal absorption data and correlation with human intestinal absorption. European Journal of Medicinal Chemistry 38:3, pages 233-243.
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Yuan H. Zhao, Joelle Le, Michael H. Abraham, Anne Hersey, Peter J. Eddershaw, Chris N. Luscombe, Darko Boutina, Gordon Beck, Brad Sherborne, Ian Cooper & James A. Platts. (2001) Evaluation of human intestinal absorption data and subsequent derivation of a quantitative structure–activity relationship (QSAR) with the Abraham descriptors. Journal of Pharmaceutical Sciences 90:6, pages 749-784.
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Karl K. Rozman, John Doull & Wayland J. HayesJr.Jr.. 2001. Handbook of Pesticide Toxicology. Handbook of Pesticide Toxicology 1 93 .
Yan-Ling He, Susan Murby, Geoffrey Warhurst, Larry Gifford, David Walker, John Ayrton, Richard Eastmond & Malcolm Rowland. (1998) Species Differences in Size Discrimination in the Paracellular Pathway Reflected by Oral Bioavailability of Poly(ethylene glycol) and d-Peptides. Journal of Pharmaceutical Sciences 87:5, pages 626-633.
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M. SCHÄFER-KORTING & E. MUTSCHLER. 1989. Determination of Beta-Blockers in Biological Material. Determination of Beta-Blockers in Biological Material 189 224 .
Karl Rozman. (2016) Disposition of Xenobiotics: Species Differences. Toxicologic Pathology 16:2, pages 123-129.
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Toshikazu Yamaguchi, Chisato Ikeda & Yutaka Sekine. (1987) Intestinal absorption of a β-adrenergic blocking agent nadolol. Enhancement of in situ and in vivo absorption of nadolol in rats. International Journal of Pharmaceutics 37:1-2, pages 127-134.
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A. V. Poteshnykh, V. K. Piotrovskii, S. A. Valevko & V. I. Metelitsa. (1986) Kinetics of the release of nadolol from the drug form and modeling of absorption in vitro. Pharmaceutical Chemistry Journal 20:12, pages 805-809.
Crossref
J.D. Fitzgerald. 1984. Pharmacology of Antihypertensive Drugs. Pharmacology of Antihypertensive Drugs 249 306 .
M. Sch�fer-Korting, N. Bach, H. Knauf & E. Mutschler. (1984) Pharmacokinetics of nadolol in healthy subjects. European Journal of Clinical Pharmacology 26:1, pages 125-127.
Crossref
Harold C. Grice. 1984. Interpretation and Extrapolation of Chemical and Biological Carcinogenicity Data to Establish Human Safety Standards. Interpretation and Extrapolation of Chemical and Biological Carcinogenicity Data to Establish Human Safety Standards 1 152 .
Monika Schäfer-Korting & Ernst Mutschler. (1982) Fluorodensitometric determination of nadolol in plasma and urine. Journal of Chromatography B: Biomedical Sciences and Applications 230:2, pages 461-465.
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PJ Cadigan, DR London, BL Pentecost, G Bianchetti, R Gomeni, JR Kilborn & PL Morselli. (2012) Cardiovascular effects of single oral doses of the new beta‐ adrenoceptor blocking agents betaxolol (SL 75212) in healthy volunteers.. British Journal of Clinical Pharmacology 9:6, pages 569-575.
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Anders Arfwidsson, Göran Hallhagen & Kurt‐Jürgen Hoffmann. (2006) A convenient method for the specific tritium labelling of beta‐adrenoceptor antagonists. Journal of Labelled Compounds and Radiopharmaceuticals 17:3, pages 369-382.
Crossref
Bruce H. Migdalof, Kishin J. Kripalani & Sampat M. Singhvi. 1979. Annual Reports in Medicinal Chemistry Volume 14. Annual Reports in Medicinal Chemistry Volume 14 188 197 .

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