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Xenobiotica
the fate of foreign compounds in biological systems
Volume 8, 1978 - Issue 8
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Original Article

Sex Differences in the Kinetic Constants of Ethylmorphine Demethylation and Type I Binding to Hepatic Microsomal Cytochrome P-450 in Mice. The Influence of Castration and Testosterone

J. Noordhoek Department of Pharmacology, Erasmus University, P.O. Box 1738, Rotterdam, The Netherlands
,
A. P. Van Den Berg Department of Pharmacology, Erasmus University, P.O. Box 1738, Rotterdam, The Netherlands
,
E. M. Savenije-chapel Department of Pharmacology, Erasmus University, P.O. Box 1738, Rotterdam, The Netherlands
&
E. Koopman-kool Department of Pharmacology, Erasmus University, P.O. Box 1738, Rotterdam, The Netherlands
Pages 515-522 | Received 07 Sep 1977, Published online: 30 Sep 2009

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R. F. Witkamp, S. M. Nijmeijer, W. C. Mennes, A. W. Rozema, J. Noordhoek & A. S. J. P. A. M. Van Miert. (1993) Regioselective O-demethylation of scoparone (6,7-dimethoxycoumarin) to assess cytochrome P450 activities in vitro in rat. Effects of gonadal steroids and the involvement of constitutive P450 enzymes. Xenobiotica 23:4, pages 401-410.
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B. P. W. Meesen, E. J. M. van Deurzen, C. T. M. van Duin, H. van Gogh & A. S. J. P. A. M. van Miert. (1986) The effect of testosterone on the plasma disappearance rates of sulphadimidine and antipyrine in castrated dwarf goats. Veterinary Quarterly 8:4, pages 343-345.
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Articles from other publishers (14)

R F Witkamp, S M Nijmeijer & A S van Miert. (1996) Cytochrome P-450 complex formation in rat liver by the antibiotic tiamulin. Antimicrobial Agents and Chemotherapy 40:1, pages 50-54.
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R. F. WITKAMP, S. M. NIJMEIJER & A. S. J. P. A. M. VAN MIERT. (2008) Tiamulin selectively inhibits oxidative hepatic steroid and drug metabolism in vitro in the pig. Journal of Veterinary Pharmacology and Therapeutics 17:4, pages 317-322.
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. 1994. Neglected Factors in Pharmacology and Neuroscience Research - Biopharmaceutics, Animal characteristics Maintenance, Testing conditions. Neglected Factors in Pharmacology and Neuroscience Research - Biopharmaceutics, Animal characteristics Maintenance, Testing conditions 154 183 .
R.F. Witkamp, H.J. Kolker, S.M. Nijmeijer, J. Noordhoek & A.S.J.P.A.M. van Miert. (1993) Selective changes in oxidative xenobiotic metabolism in vivo and in vitro after parenteral administration of recombinant bovine somatotrophin to rats. Research in Veterinary Science 55:1, pages 31-37.
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R. F. WITKAMP, S. M. NIJMEIJER, H.J. KOLKER, J. NOORDHOEK & A.S.J.P. A. M. VAN MIERT. (2008) Effect of gonadal hormones on the plasma clearance and metabolite formation of antipyrine in the dwarf goat. Journal of Veterinary Pharmacology and Therapeutics 16:2, pages 164-173.
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Gerben A.E. van 't Klooster, Felice M.A. Woutersen-van Nijnanten, Herman J. Kolker, Jan Noordhoek & Adelbert S.J.P.A.M. van Miert. (1992) Improved high-performance liquid chromatographic method for the determination of ethylmorphine and its metabolites in microsomal incubations and cell culture media. Journal of Chromatography B: Biomedical Sciences and Applications 579:1, pages 158-164.
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R. F. WITKAMP, S. M. NIJMEIJER, C. T. M. VAN DUIN, M. M. BEVERS, TH. WENSING, H. VAN GOGH & A.S.J.P.A.M. VAN MIERT. (2008) Has bovine somatotropin (BST) an effect upon drug disposition? Comparative studies in goats and cattle with sulphadimidine and antipyrine after parenteral administration of BST, zeranol and proligestone. Journal of Veterinary Pharmacology and Therapeutics 12:2, pages 163-178.
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Toshiaki Miura, Hitoshi Shimada, Hiroaki Ohi, Masayuki Komori, Takao Kodama & Tetsuya Kamataki. (1989) Interspecies Homology of Cytochrome P-450: Inhibition by Anti-P-450-Male Antibodies of Testosterone Hydroxylases in Liver Microsomes from Various Animal Species Including Man. Japanese Journal of Pharmacology 49:3, pages 365-373.
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J. F. M. NOUWS, B. P. W. MEESEN, H. VAN GOGH, C. KORSTANJE, A. S.J. P. A. M. VAN MIERT, T. B. VREE & M. DEGEN. (1988) The effect of testosterone and rutting on the metabolism and pharmacokinetics of sulphadimidine in goats. Journal of Veterinary Pharmacology and Therapeutics 11:2, pages 145-154.
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Alessandra Verdina, Giovanna De Angelis, Enzo Funari, Emanuela Testai & Luciano Vittozzi. (1987) Xenobiotic-metabolizing enzyme systems in test fish—II. The ethylmorphine activity of guppy (Poecilia reticulata) liver. Comparative Biochemistry and Physiology Part B: Comparative Biochemistry 88:2, pages 619-624.
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Y. Brandstetter, J. Kaplanski, V. Leibson & Z. Ben-Zvi. (1986) The effects of estrus cycle on drug metabolism in the rat. European Journal of Drug Metabolism and Pharmacokinetics 11:4, pages 251-254.
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Fr. Pasleau, P. Kremers & J.E. Gielen. (1980) Sex differences in the activity of different cytochrome p450 dependent steroid 16α-hydroxylases in rat liver. Journal of Steroid Biochemistry 13:7, pages 733-736.
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John J. Stegeman & Mordechai Chevioni. (1980) Sex differences in cytochrome P-450 and mixed-function oxygenase activity in gonadally mature trout. Biochemical Pharmacology 29:4, pages 553-558.
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Watanabe Minro, Tamura Yoshiko & Abe Tatsuya. (1980) Sex-dependent difference in aryl hydrocarbon hydroxylase activity in mouse liver. Toxicology Letters 5:1, pages 55-60.
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