Advanced search
Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 8, 1978 - Issue 2
Submit an article Journal homepage
14
Views
42
CrossRef citations to date
0
Altmetric
Original Article

A Comparison of Drug-Metabolizing Capability in Isolated Viable Rat Hepatocytes and Renal Tubule Fragments

Jeffrey R. Fry Department of Biochemistry, University of Surrey, Guildford, Surrey, GU 2 5XH, UK
,
Philip Wiebkin Department of Biochemistry, University of Surrey, Guildford, Surrey, GU 2 5XH, UK
,
John Kao Department of Biochemistry, University of Surrey, Guildford, Surrey, GU 2 5XH, UK
,
Carol A. Jones Department of Biochemistry, University of Surrey, Guildford, Surrey, GU 2 5XH, UK
,
Jennie Gwynn Department of Biochemistry, University of Surrey, Guildford, Surrey, GU 2 5XH, UK
&
James W. Bridges Department of Biochemistry, University of Surrey, Guildford, Surrey, GU 2 5XH, UK
Pages 113-120 | Received 18 Apr 1977, Published online: 30 Sep 2009

Citations (42)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (7)

Peter H. Bach & Enoch N. Kwizera. (1988) Nephrotoxicity: A rational approach to target cell injury in vitro in the kidney. Xenobiotica 18:6, pages 685-698.
Read now
Peter H. Bach, James W. Bridges & Gilbert H. Mudge. (1985) Chemically Induced Renal Papillary Necrosis and Upper Urothelial Carcinoma. Part 1. CRC Critical Reviews in Toxicology 15:3, pages 217-329.
Read now
Peter H. Bach, James W. Bridges & Gilbert H. Mudge. (1985) Chemically Induced Renal Papillary Necrosis and Upper Urothelial Carcinoma. Part 2. CRC Critical Reviews in Toxicology 15:4, pages 331-439.
Read now
Glenn F. Rush, Jacqueline H. Smith, John F. Newton, Jerry B. Hook & William O. Berndt. (1984) Chemically Induced Nephrotoxicity: Role of Metabolic Activation. CRC Critical Reviews in Toxicology 13:2, pages 99-160.
Read now
T. C. Orton, A. E. Sorman, D. N. Crisp & A. P. Sturdee. (1983) Dynamics of xenobiotic metabolism by isolated rat hepatocytes using a multichannel perifusion system. Xenobiotica 13:12, pages 743-753.
Read now
K. R. Emslie, M. C. Smail, I. C. Calder, S. J. Hart & J. D. Tange. (1981) Paracetamol and the isolated perfused kidney: Metabolism and functional effects. Xenobiotica 11:1, pages 43-50.
Read now
L. L. Szinicz & N. Weger. (1980) Effects of 4-dimethylaminophenol in rat kidneys, isolated rat kidney tubules and hepatocytes. Xenobiotica 10:7-8, pages 611-620.
Read now

Articles from other publishers (35)

Teresa M. DesRochers, Erica Palma & David L. Kaplan. (2014) Tissue-engineered kidney disease models. Advanced Drug Delivery Reviews 69-70, pages 67-80.
Crossref
Peter Greaves. 2012. Histopathology of Preclinical Toxicity Studies. Histopathology of Preclinical Toxicity Studies 537 614 .
Peter Greaves. 2007. Histopathology of Preclinical Toxicity Studies. Histopathology of Preclinical Toxicity Studies 570 660 .
Peter Greaves. 2000. Histopathology of Preclinical Toxicity Studies. Histopathology of Preclinical Toxicity Studies 545 626 .
W. G. Guder & Francois Morel. 2011. Comprehensive Physiology. Comprehensive Physiology 2119 2164 .
Martin F. Wilks & Peter H. Bach. 1992. Urinary Enzymes. Urinary Enzymes 299 317 .
Pieter J. Boogaard, J.Fred Nagelkerke & Gerard J. Mulder. (1990) Renal proximal tubular cells in suspension or in primary culture as in vitro models to study nephrotoxicity. Chemico-Biological Interactions 76:3, pages 251-291.
Crossref
E. A. Lock. 1987. Nephrotoxicity in the experimental and clinical situation. Nephrotoxicity in the experimental and clinical situation 429 461 .
Angela M. Mitchell, Jean-Claude Lhuguenot, James W. Bridges & Clifford R. Elcombe. (1985) Identification of the proximate peroxisome proliferator(s) derived from Di(2-ethylhexyl) phthalate. Toxicology and Applied Pharmacology 80:1, pages 23-32.
Crossref
Q.Y. Chen & L.R. Schwarz. (1985) Sulfation in isolated kidney tubule fragments of rats dependence of inorganic sulfate. Biochemical Pharmacology 34:9, pages 1363-1366.
Crossref
H. J. Burger, G. Hauber, W. Schlote & M. Schwenk. (1985) Comparison of isolated cells from liver, colon, and kidney of guinea pig. American Journal of Physiology-Cell Physiology 248:3, pages C271-C278.
Crossref
Michael Schwenk & Mathias Locher. (1985) 1-Naphthol conjugation in isolated cells from liver, jejunum, ileum, colon and kidney of the guinea pig. Biochemical Pharmacology 34:5, pages 697-701.
Crossref
I. C. Hsu, M. M. Lipsky, K. E. Cole, C. H. Su & B. F. Trump. (1985) Isolation and culture of hepatocytes from human liver of immediate autopsy. In Vitro Cellular & Developmental Biology 21:3, pages 154-160.
Crossref
Constantin Cojocel, Keizo Maita, Dale A. Pasino, Chao-Hen Kuo & Jerry B. Hook. (1983) Metabolic heterogeneity of the proximal and distal kidney tubules. Life Sciences 33:9, pages 855-861.
Crossref
A.P. Sturdee, J.M. Beirne, A.E. Sörman, T.C. Orton & D.M. Crisp. (1983) Metabolic capability of rat hepatocytes isolated by perfusion and tissue slice techniques. Life Sciences 32:13, pages 1463-1469.
Crossref
Philip Wiebkin, Marianne S. Sieg, R.Earl Nelson, Ronald N. Hines & Russell A. Prough. (1982) Inhibition of metabolism-mediated cytotoxicity by 1,1-disubstituted hydrazines in mouse mastocytoma (line p815) cells. Biochemical Pharmacology 31:18, pages 2921-2928.
Crossref
Philip Wiebkin, Russell A. Prough & James W. Bridges. (1982) The metabolism and toxicity of some organotin compounds in isolated rat hepatocytes. Toxicology and Applied Pharmacology 62:3, pages 409-420.
Crossref
Jeffrey R. Fry. (1982) THE METABOLISM OF DRUGS BY ISOLATED HEPATOCYTES. Drug Metabolism and Drug Interactions 4:2-3.
Crossref
Bettie Sue Siler Masters, Richard T. Okita, Yukio Yasukochi, Linda K. Parkhill & Jane H. Dees. 1982. Proteins in Biology and Medicine. Proteins in Biology and Medicine 183 199 .
David J. Bates, Allan B. Foster & Michael Jarman. (1981) The metabolism of cyclophosphamide by isolated rat hepatocytes. Biochemical Pharmacology 30:22, pages 3055-3063.
Crossref
Jeffrey R. Fry & Nicholas K. Perry. (1981) The effect of aroclor 1254 pretreatment on the phase I and phase II metabolism of 7-ethoxycoumarin in isolated viable rat kidney cells. Biochemical Pharmacology 30:11, pages 1197-1201.
Crossref
Kari Ormstad, Sten Orrenius & Dean P. Jones. 1981. Detoxication and Drug Metabolism: Conjugation and Related Systems. Detoxication and Drug Metabolism: Conjugation and Related Systems 137 146 .
Jeffrey R. Fry. 1981. Detoxication and Drug Metabolism: Conjugation and Related Systems. Detoxication and Drug Metabolism: Conjugation and Related Systems 130 137 .
Vernon L. Singleton. 1981. 149 242 .
William M. Kluwe & Jerry B. Hook. (1981) Comparative induction of xenobiotic metabolism in rodent kidney, testis and liver by commercial mixtures of polybrominated biphenyls and polychlorinated biphenyls, phenobarbital and 3-methylcholanthrene: Absolute and temporal effects. Toxicology 20:2-3, pages 259-273.
Crossref
Annalaura Paganuzzi Stammati, Vittorio Silano & Flavia Zucco. (1981) Toxicology investigations with cell culture systems. Toxicology 20:2-3, pages 91-153.
Crossref
M.W. Anders. (1980) Metabolism of drugs by the kidney. Kidney International 18:5, pages 636-647.
Crossref
Jeffrey R. Fry & James W. Bridges. (1980) The metabolism of 7-ethoxycoumarin in primary maintenance cultures of adult rat hepatocytes. Naunyn-Schmiedeberg's Archives of Pharmacology 311:1, pages 85-90.
Crossref
James W. Bridges. (1980) Monooxygenase reactions glucuronic acid and sulphate conjugation in isolated hepatocytes. Toxicology 18:3, pages 195-204.
Crossref
J.W. Sear & J.D. McGivan. (1980) The metabolism of alphaxalone by isolated rat hepatocytes. Biochemical Pharmacology 29:2, pages 248-250.
Crossref
F. J. Wiebel, M. Lambiotte, K.-H. Summer & T. Wolff. 1980. Carcinogenesis: Fundamental Mechanisms and Environmental Effects. Carcinogenesis: Fundamental Mechanisms and Environmental Effects 347 361 .
Philip Wiebkin, Gerald L. Parker, Jeffrey R. Fry & James W. Bridges. (1979) Effect of various metabolic inhibitors on biphenyl metabolism in isolated rat hepatocytes. Biochemical Pharmacology 28:22, pages 3315-3321.
Crossref
Dean P. Jones, Gun-Britt Sundby, Kari Ormstad & Sten Orrenius. (1979) Use of isolated kidney cells for study of drug metabolism. Biochemical Pharmacology 28:6, pages 929-935.
Crossref
D.P. Jones, H. Thor, B. Andersson & S. Orrenius. (1978) Detoxification reactions in isolated hepatocytes. Role of glutathione peroxidase, catalase, and formaldehyde dehydrogenase in reactions relating to N-demethylation by the cytochrome P-450 system.. Journal of Biological Chemistry 253:17, pages 6031-6037.
Crossref
John Kao, Carol A. Jones, Jeffrey R. Fry & James W. Bridges. (1978) Species differences in the metabolism of benzoic acid by isolated hepatocytes and kidney tubule fragments. Life Sciences 23:12, pages 1221-1228.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.