Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 8, 1978 - Issue 3
39
Views
39
CrossRef citations to date
0
Altmetric
Research Article

Disposition and Metabolism of Benoxaprofen in Laboratory Animals and Man

&
Pages 133-144 | Received 12 Apr 1977, Published online: 22 Sep 2008

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

Yurong Lai. (2009) Identification of interspecies difference in hepatobiliary transporters to improve extrapolation of human biliary secretion. Expert Opinion on Drug Metabolism & Toxicology 5:10, pages 1175-1187.
Read now
Christian Skonberg, Jrgen Olsen, Kim Grimstrup Madsen, Steen Honor Hansen & Mark P Grillo. (2008) Metabolic activation of carboxylic acids. Expert Opinion on Drug Metabolism & Toxicology 4:4, pages 425-438.
Read now
Urs A. Boelsterli, Hyman J. Zimmerman & Anke Kretz-Rommel. (1995) Idiosyncratic Liver Toxicity of Nonsteroidal Antiinflammatory Drugs: Molecular Mechanisms and Pathology. Critical Reviews in Toxicology 25:3, pages 207-235.
Read now
Bruce Clark, Dennis A. Smith & John Caldwell. (1984) Pharmacokinetics and Toxicity Testing. CRC Critical Reviews in Toxicology 12:4, pages 343-385.
Read now
Jeffrey S. Fleitman, Charles S. Lee & John H. Perrin. (1980) A Rapid High Pressure Liquid Chromatographic Assay of Benoxaprofen in Plasma. Journal of Liquid Chromatography 3:8, pages 1165-1172.
Read now
D. H. Chatfield, J. N. Green, J. C. Kao, W. J. Ross & T. J. Woodage. (1979) The Metabolism of Isamoxole in the Rat and Guinea-Pig. Xenobiotica 9:10, pages 585-594.
Read now

Articles from other publishers (33)

Dennis A. Smith, Kevin Beaumont, Tristan S. Maurer & Li Di. (2017) Relevance of Half-Life in Drug Design. Journal of Medicinal Chemistry 61:10, pages 4273-4282.
Crossref
Alexander V. LyubimovMark P. Grillo. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 56 .
Andrew J Hutt & John Caldwell. (1983) The metabolic chiral inversion of 2-arylpropionic acids—a novel route with pharmacological consequences. Journal of Pharmacy and Pharmacology 35:11, pages 693-704.
Crossref
S C R Meacock & E Ann Kitchen. (1979) Effects of the non-steroidal anti-inflammatory drug benoxaprofen on leucocyte migration. Journal of Pharmacy and Pharmacology 31:1, pages 366-370.
Crossref
Sophie L. Regan, James L. Maggs, Thomas G. Hammond, Craig Lambert, Dominic P. Williams & B. Kevin Park. (2010) Acyl glucuronides: the good, the bad and the ugly. Biopharmaceutics & Drug Disposition 31:7, pages 367-395.
Crossref
R. Scott Obach. (2009) Glycerolysis of Acyl Glucuronides as an Artifact of in Vitro Drug Metabolism Incubations. Drug Metabolism and Disposition 37:8, pages 1581-1586.
Crossref
K. N. Woodward. 2009. Veterinary Pharmacovigilance. Veterinary Pharmacovigilance 715 748 .
K. N. Woodward. 2009. Veterinary Pharmacovigilance. Veterinary Pharmacovigilance 297 345 .
Jonathon N. Bauman, Joan M. Kelly, Sakambari Tripathy, Sabrina X. Zhao, Wing W. Lam, Amit S. Kalgutkar & R. Scott Obach. (2009) Can In Vitro Metabolism-Dependent Covalent Binding Data Distinguish Hepatotoxic from Nonhepatotoxic Drugs? An Analysis Using Human Hepatocytes and Liver S-9 Fraction. Chemical Research in Toxicology 22:2, pages 332-340.
Crossref
. (2005) Effect of Probenecid on the Pharmacokinetic Behavior of Pranoprofen in Rats. Journal of Korean Pharmaceutical Sciences 35:6, pages 397-402.
Crossref
Jennifer Q. Dong, Jianhua Liu & Philip C. Smith. (2005) Role of benoxaprofen and flunoxaprofen acyl glucuronides in covalent binding to rat plasma and liver proteins in vivo. Biochemical Pharmacology 70:6, pages 937-948.
Crossref
K. N. WOODWARD. (2005) Veterinary pharmacovigilance. Part 6. Predictability of adverse reactions in animals from laboratory toxicology studies. Journal of Veterinary Pharmacology and Therapeutics 28:2, pages 213-231.
Crossref
Kiminori Mohri, Kenji Okada & Leslie Z. Benet. (2005) Stereoselective Taurine Conjugation of (R)-Benoxaprofen Enantiomer in Rats: In Vivo and in Vitro Studies Using Rat Hepatic Mitochondria and Microsomes. Pharmaceutical Research 22:1, pages 79-85.
Crossref
Maria Shipkova, Victor William Armstrong, Michael Oellerich & Eberhard Wieland. (2003) Acyl Glucuronide Drug Metabolites: Toxicological and Analytical Implications. Therapeutic Drug Monitoring 25:1, pages 1-16.
Crossref
Kalpana Krishnaswami, Alexander Tropsha & Philip C. Smith. (1995) Semi-empirical calculations of intramolecular acyl transfer in cis-enols of O-aroyl acetylacetones. Journal of Molecular Structure: THEOCHEM 332:1-2, pages 85-91.
Crossref
Ching-Shih Chen, Woan-Ru Shieh, Pei-Heng Lu, Shawn Harriman & Ching-Yu Chen. (1991) Metabolic stereoisomeric inversion of ibuprofen in mammals. Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology 1078:3, pages 411-417.
Crossref
Andrew D. Ayrton, Costas Ioannides & Dennis V. Parke. (1991) Induction of the cytochrome P450 I and IV families and peroxisomal proliferation in the liver of rats treated with benoxaprofen. Biochemical Pharmacology 42:1, pages 109-115.
Crossref
D.F.V. Lewis, C. Ioannides & D.V. Parke. (1990) A retrospective study of the molecular toxicology of benoxaprofen. Toxicology 65:1-2, pages 33-47.
Crossref
N. Muller, E. Payan, F. Lapicque, B. Bannwarth & P. Netter. (1990) Pharmacological aspects of chiral nonsteroidal anti-inflammatory drugs. Fundamental & Clinical Pharmacology 4:6, pages 617-634.
Crossref
Charles T. Eason, Frank W. Bonner & Dennis V. Parke. (1990) The importance of pharmacokinetic and receptor studies in drug safety evaluation. Regulatory Toxicology and Pharmacology 11:3, pages 288-307.
Crossref
G. Segre, E. Bianchi & G. Zanolo. (1988) Pharmacokinetics of flunoxaprofen in rats, dogs, and monkeys. Journal of Pharmaceutical Sciences 77:8, pages 670-673.
Crossref
J. Caldwell & A. J. Hutt. 1987. Side-Effects of Anti-Inflammatory Drugs. Side-Effects of Anti-Inflammatory Drugs 217 228 .
A. N. Worden. 1987. The Future of Predictive Safety Evaluation. The Future of Predictive Safety Evaluation 41 46 .
Kathleen M. Knights, Michael R. Cassidy & Roger Drew. (1986) Benoxaprofen induced toxicity in isolated rat hepatocytes. Toxicology 40:3, pages 327-339.
Crossref
Andrew J. Hutt, Sylvie Fournel & John Caldwell. (1986) Application of a radial compression column to the high-performance liquid chromatographic separation of the enantiomers of some 2-arylpropionic acids as their diastereoisomeric S-()-1-(naphthen-1-YL)ethylamides. Journal of Chromatography B: Biomedical Sciences and Applications 378, pages 409-418.
Crossref
Dennis V. Parke. (1983) Species differences in pharmacokinetics. Veterinary Research Communications 7:1, pages 285-300.
Crossref
Arleen B. Rifkind & Haidrun Muschick. (1983) Benoxaprofen suppression of polychlorinated biphenyl toxicity without alteration of mixed function oxidase function. Nature 303:5917, pages 524-526.
Crossref
Marshall J. Palmoski & Kenneth D. Brandt. (2005) Benoxaprofen stimulates proteoglycan synthesis in normal canine knee cartilage in vitro. Arthritis & Rheumatism 26:6, pages 771-774.
Crossref
R. K. Verbeeck & S. M. Wallace. (1983) Does fenbufen have a large distribution volume or is it subject to extensive presystemic elimination?. European Journal of Clinical Pharmacology 24:1, pages 137-138.
Crossref
Stephen L. Dahl & John R. Ward. (2012) Pharmacology, Clinical Efficacy, and Adverse Effects of the Nonsteroidal Anti‐Inflammatory Agent Benoxaprofen. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 2:6, pages 354-365.
Crossref
Robin G. Simmonds, Trevor J. Woodage, Susan M. Duff & John N. Green. (1980) Stereospecific inversion of (R)-(−)-benoxaprofen in rat and man. European Journal of Drug Metabolism and Pharmacokinetics 5:3, pages 169-172.
Crossref
Lena Ekman, Björn Lindström, Gunhild Nilsson & Lars Wibell. (1980) Determination of benoxaprofen in plasma and urine by liquid chromatography. Journal of Chromatography B: Biomedical Sciences and Applications 182:3, pages 478-481.
Crossref
ANTHONY S. RIDOLFO, RODNEY NICKANDER & WALTER M. MIKULASCHEK. (1979) Fenoprofen and Benoxaprofen. Clinics in Rheumatic Diseases 5:2, pages 393-410.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.