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Xenobiotica
the fate of foreign compounds in biological systems
Volume 8, 1978 - Issue 9
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Original Article

Metabolic Fate of 1-Hexylcarbamoyl-5-fluorouracil in Rats

T. Kobari Institute of Biological Science, Mitsui Pharmaceuticals, Inc., Togo, Mobara, Chiba, Japan
,
K. Tan Institute of Biological Science, Mitsui Pharmaceuticals, Inc., Togo, Mobara, Chiba, Japan
,
M. Kumakura Institute of Biological Science, Mitsui Pharmaceuticals, Inc., Togo, Mobara, Chiba, Japan
,
S. Watanabe Institute of Biological Science, Mitsui Pharmaceuticals, Inc., Togo, Mobara, Chiba, Japan
,
I. Shirakawa Institute of Biological Science, Mitsui Pharmaceuticals, Inc., Togo, Mobara, Chiba, Japan
,
H. Kobayashi Institute of Biological Science, Mitsui Pharmaceuticals, Inc., Togo, Mobara, Chiba, Japan
,
A. Ujiie Institute of Biological Science, Mitsui Pharmaceuticals, Inc., Togo, Mobara, Chiba, Japan
,
Y. Miyama Institute of Biological Science, Mitsui Pharmaceuticals, Inc., Togo, Mobara, Chiba, Japan
,
H. Namekawa Institute of Biological Science, Mitsui Pharmaceuticals, Inc., Togo, Mobara, Chiba, Japan
&
H. Yamamoto Institute of Biological Science, Mitsui Pharmaceuticals, Inc., Togo, Mobara, Chiba, Japan
 show all
Pages 547-556 | Received 10 Nov 1977, Published online: 30 Sep 2009

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T. Kobari, Y. Iguro, A. Ujiie & H. Namekawa. (1981) Metabolism of 1-hexylcarbamoyl-5-fluorouracil (HCFU), a new antitumour agent, in rats, rabbits and dogs. Xenobiotica 11:1, pages 57-62.
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M. Iigo, A. Nakamura, K. Kuretani & A. Hoshi. (1980) Metabolic fate of 1-hexylcarbamoyl-5-fluorouracil after oral administration in mice. Xenobiotica 10:11, pages 847-854.
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Articles from other publishers (19)

Mohammad Mohiminul Islam & Shama P. Mirza. (2022) Versatile use of Carmofur: A comprehensive review of its chemistry and pharmacology. Drug Development Research 83:7, pages 1505-1518.
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Kangni Wu, Yanghui Xiu, Pan Zhou, Yan Qiu & Yuhang Li. (2019) A New Use for an Old Drug: Carmofur Attenuates Lipopolysaccharide (LPS)-Induced Acute Lung Injury via Inhibition of FAAH and NAAA Activities. Frontiers in Pharmacology 10.
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Natalia Realini, Carlos Solorzano, Chiara Pagliuca, Daniela Pizzirani, Andrea Armirotti, Rosaria Luciani, Maria Paola Costi, Tiziano Bandiera & Daniele Piomelli. (2013) Discovery of highly potent acid ceramidase inhibitors with in vitro tumor chemosensitizing activity. Scientific Reports 3:1.
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H Ikehira, F Girard, T Obata, H Ito, H Yoshitomi, M Miyazaki, N Nakajima, H Kamei, Y Kanazawa, H Takano, H Ito, S Tanada & Y Sasaki. (1999) A preliminary study for clinical pharmacokinetics of oral fluorine anticancer medicines using the commercial MRI system 19F-MRS.. The British Journal of Radiology 72:858, pages 584-589.
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Keizo Sugimachi, Yoshihiko Maehara, Michio Ogawa, Teruo Kakegawa, Masao Tomita & Tsuyoshi Akiyoshi. (1996) Postoperative chemotherapy for colorectal cancer by combining 5-fluorouracil infusion and 1-hexylcarbamoyl-5-fluorouracil administration after curative resection. Cancer 77:1, pages 36-43.
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Kenji Takenaka, Takashi Kanematsu, Mitsuo Shimada & Keizo Sugimachi. (1989) Low dose 1-hexylcarbamoyl-5-fluorouracil (HCFU) recommended for cirrhotic patients with hepatocellular carcinoma. European Journal of Cancer and Clinical Oncology 25:8, pages 1191-1195.
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Riki Okeda, Makoto Shibutani, Takashi Matsuo & Toshihiko Kuroiwa. (1988) SUBACUTE NEUROTOXICITY OF 5-FLUOROURACIL and ITS DERIVATIVE, CARMOFUR, IN CATS. Pathology International 38:10, pages 1255-1266.
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Yoshihiko Maehara, Hiroki Kusumoto, Hideaki Anal, Tetsuya Kusumoto, Yoichiro Hiramoto & Keizo Sugimachi. (1987) 1-hexylcarbamoyl-5-fluorouracil is more cytostatic than 5-fluorouracil against human tumors in vitro. European Journal of Cancer and Clinical Oncology 23:10, pages 1511-1515.
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S. Kuzuhara, N. Ohkoshi, K. Kanemaru, H. Hashimoto, T. Nakanishi & Y. Toyokura. (1987) Subacute leucoencephalopathy induced by carmofur, a 5-fluorouracil derivative. Journal of Neurology 234:6, pages 365-370.
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Hitoshi Sasaki, Tohru Takahashi, Junzo Nakamura, Ryoji Konishi & Juichiro Shibasaki. (1986) Intestinal Absorption of 5-Fluorouracil and its Alkylcarbamoyl Derivatives in the Rat Small Intestine. Journal of Pharmaceutical Sciences 75:7, pages 676-679.
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Makoto Ogawa. 1985. Experimental and Clinical Progress in Cancer Chemotherapy. Experimental and Clinical Progress in Cancer Chemotherapy 133 140 .
Anthony F. Hadfield & Alan C. Sartorelli. 1984. 21 67 .
R. Okeda, T. Karakama, S. Kimura, S. Toizumi, T. Mitsushima & Y. Yokoyama. (1984) Neuropathologic study on chronic neurotoxicity of 5-fluorouracil and its masked compounds in dogs. Acta Neuropathologica 63:4, pages 334-343.
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Osamu Nakajima, Yohko Yoshida, Takako Isoda, Yuhzo Takemasa, Yukio Imamura & Yoshiyuki Koyama. (1981) Quantitative determination of 1-hexylcarbamoyl-5-fluorouracil and its metabolites in man. Journal of Chromatography B: Biomedical Sciences and Applications 225:1, pages 91-97.
Crossref
Hiromi Isomura, Saburo Higuchi & Shigeo Kawamura. (1981) Gas chromatographic—mass spectrometric determination of plasma 5-fluorouracil after administration of 1-hexylcarbamoyl-5-fluorouracil to dogs and humans. Journal of Chromatography B: Biomedical Sciences and Applications 224:3, pages 423-429.
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. (1981) . Kanzo 22:6, pages 915-915.
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Y. Sakurai. 1981. New Drugs in Cancer Chemotherapy. New Drugs in Cancer Chemotherapy 91 99 .
Akira Kono, Yasuhiro Hara, Sanetomi Eguchi, Mutsuko Tanaka & Yoshikazu Matsushima. (1980) Determination of two new metabolites of 1-hexylcarbamoyl-5-fluorouracil in biomedical specimens by high-performance liquid chromatography. Journal of Chromatography B: Biomedical Sciences and Applications 182:1, pages 125-129.
Crossref
Akira Kono, Mutsuko Tanaka, Sanetomi Eguchi, Yasuhiro Hara & Yoshikazu Matsushima. (1979) Determination of 1-hexylcarbamoyl-5-fluorouracil and its metabolites in biomedical specimens by high-performance liquid chromatography. Journal of Chromatography B: Biomedical Sciences and Applications 163:1, pages 109-113.
Crossref

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