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Xenobiotica
the fate of foreign compounds in biological systems
Volume 8, 1978 - Issue 9
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Original Article

Stereoselective Disposition of Fenfluramine Enantiomers in the Rat

A. Jori Istituto di Ricerche Farmacologiche “Mario Negri” Via Eritrea, 62-20157, Milan, Italy
,
P. De Ponte Istituto di Ricerche Farmacologiche “Mario Negri” Via Eritrea, 62-20157, Milan, Italy
&
S. Caccia Istituto di Ricerche Farmacologiche “Mario Negri” Via Eritrea, 62-20157, Milan, Italy
Pages 583-588 | Received 25 Oct 1977, Published online: 30 Sep 2009

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S. Garattini, S. Cactia, T. Mennini, R. Samanin, S. Consolo & H. Ladinsky. (1979) Biochemical pharmacology of the anorectic drug fenfluramine: a review. Current Medical Research and Opinion 6:sup1, pages 15-27.
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Articles from other publishers (16)

Natalia Erenburg, Roa’a Hamed, Chanan Shaul, Emilio Perucca & Meir Bialer. (2023) Comparative activity of the enantiomers of fenfluramine and norfenfluramine in rodent seizure models, and relationship with their concentrations in plasma and brain. Epilepsia 64:6, pages 1673-1683.
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E Marzi, K Gambazza, G Piccinelli, S Garattini & I Bartoŝek. (1981) Effect of optical isomers of (±)-fenfluramine on pentobarbitone brain and plasma concentrations and sleeping time. Journal of Pharmacy and Pharmacology 33:1, pages 677-679.
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Mark G. Le Sage, David Stafford & John R. Glowa. (2013) EFFECTS OF ANORECTIC DRUGS ON FOOD INTAKE UNDER PROGRESSIVE‐RATIO AND FREE‐ACCESS CONDITIONS IN RATS. Journal of the Experimental Analysis of Behavior 82:3, pages 275-292.
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Amal Kaddoumi, Mihoko N Nakashima & Kenichiro Nakashima. (2001) Fluorometric determination of dl-fenfluramine, dl-norfenfluramine and phentermine in plasma by achiral and chiral high-performance liquid chromatography. Journal of Chromatography B: Biomedical Sciences and Applications 763:1-2, pages 79-90.
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Mont R. Juchau, Robert J. Walker, J. Paul Fawcett, R. Sutherland, Noel W. Preston, Sanjay Batra, Manju Seth, A. P. Bhaduri, Wilhelm Schoner, James W. Fisher, Hiroshi Ohtaka & Toshio FujitaSanjay Batra, Manju Seth & A. P. Bhaduri. 1993. Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques. Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques 191 248 .
Alan F. Casy & George H. DewarAlan F. Casy & George H. Dewar. 1993. The Steric Factor in Medicinal Chemistry. The Steric Factor in Medicinal Chemistry 49 71 .
Martin D. Schechter. (1990) Temporal differences in behavioral effect of fenfluramine and norfenfluramine. Pharmacology Biochemistry and Behavior 35:3, pages 527-531.
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F. Jamali, R. Mehvar & F.M. Pasutto. (1989) Enantioselective Aspects of Drug Action and Disposition: Therapeutic Pitfalls. Journal of Pharmaceutical Sciences 78:9, pages 695-715.
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Judith D. Schaechter & Richard J. Wurtman. (1989) Effect of chronic d-fenfluramine administration on rat hypothalamic serotonin levels and release. Life Sciences 44:4, pages 265-271.
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N.R. Srinivas, J.W. Hubbard, J.K. Cooper & K.K. Midha. (1988) Enantioselective gas chromatographic assay with electron-capture detection for dl-fenfluramine and dl-norfenfluramine in plasma. Journal of Chromatography B: Biomedical Sciences and Applications 433, pages 105-117.
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J.W. Hubbard, D. Ganes, H.K. Lim & K.K. Midha. (1986) Chiral pharmacology and its consequences for therapeutic monitoring. Clinical Biochemistry 19:2, pages 107-112.
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Tiziana Mennini, Silvio Garattini & Silvio Caccia. (1985) Anorectic effect of fenfluramine isomers and metabolites: Relationship between brain levels and in vitro potencies on serotonergic mechanisms. Psychopharmacology 85:1, pages 111-114.
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S. Caccia, G. Dagnino, S. Garattini, G. Guiso, R. Madonna & M. G. Zanini. (1981) Kinetics of fenfluramine isomers in the rat. European Journal of Drug Metabolism and Pharmacokinetics 6:4, pages 297-301.
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S. Caccia, M. Ballabio & P. De Ponte. (1979) Pharmacokinetics of fenfluramine enantiomers in man. European Journal of Drug Metabolism and Pharmacokinetics 4:3, pages 129-132.
Crossref
Ho-Leung Fung, Bruce J. Aungst & Richard A. Morrison. 1979. Annual Reports in Medicinal Chemistry Volume 14. Annual Reports in Medicinal Chemistry Volume 14 309 320 .
Bruce H. Migdalof, Kishin J. Kripalani & Sampat M. Singhvi. 1979. Annual Reports in Medicinal Chemistry Volume 14. Annual Reports in Medicinal Chemistry Volume 14 188 197 .

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