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Xenobiotica
the fate of foreign compounds in biological systems
Volume 8, 1978 - Issue 12
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Research Article

Aromatic Oxidation of Some Phenothiazines

Arnold H. Beckett Department of Pharmacy, Chelsea College, (University of London), Manresa Road, London, SW3 6LX, UK
&
Goy E. Navas Department of Pharmacy, Chelsea College, (University of London), Manresa Road, London, SW3 6LX, UK
Pages 721-736 | Received 09 Jan 1978, Published online: 22 Sep 2008

Citations (16)

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Stephen C. Mitchell, Rosemary H. Waring & Robert L. Smith. (2014) Curiosities in drug metabolism. Xenobiotica 44:7, pages 666-676.
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J. B. Sutherland, J. P. Freeman, T. M. Heinze, J. D. Moody, I. A. Parshikov, A. J. Williams & D. Zhang. (2001) Oxidation of phenothiazine and phenoxazine by Cunninghamella elegans. Xenobiotica 31:11, pages 799-809.
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A. H. Beckett, G. E. Navas & A. J. Hutt. (1988) Metabolism of chlorpromazine and promazine in vitro: Isolation and characterization of N-oxidation products. Xenobiotica 18:1, pages 61-74.
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A. H. Beckett, A. J. Hutt & G. E. Navas. (1983) Metabolism of imipramine in vitro: synthesis and characterization of N-hydroxydesmethylimipramine. Xenobiotica 13:7, pages 391-405.
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S. C. Mitchell. (1982) Mammalian Metabolism of Orally Administered Phenothiazine. Drug Metabolism Reviews 13:2, pages 319-343.
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A. J. Hutt, G. E. Navas & A. H. Beckett. (1982) Metabolic oxidation of desmethylchlorimipramine in vitro by 9000 g rabbit-liver preparations. Xenobiotica 12:10, pages 645-655.
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B. A. Clement & A. H. Beckett. (1981) Metabolism of promethazine in vitro. Identification of N-oxidized products. Xenobiotica 11:9, pages 609-618.
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Articles from other publishers (9)

Zhifeng Xiao, Hannah F. Drake, Gregory S. Day, Jason E. Kuszynski, Hengyu Lin, Haomiao Xie, Peiyu Cai, Matthew R. Ryder & Hong-Cai Zhou. (2022) Photoinduced reversible phase transition in a phenothiazine-based metal-organic framework. Cell Reports Physical Science 3:10, pages 101074.
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Weiwei Yang, Bizhou Lin, Qianru Yao, Guohua Zhang & Shaofeng Jiang. (2016) Trititanate-nanosheet incorporated hydrogels: Self-initiated photopolymerization and application in photodegradation of methylene violet. Polymer Composites 37:9, pages 2811-2819.
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A H BeckettA J Hutt. (1982) In vitro metabolism in the rabbit of desipramine and nortriptyline to yield carboxylic acids. Journal of Pharmacy and Pharmacology 34:9, pages 614-614.
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R. Scott Obach. (2009) Glycerolysis of Acyl Glucuronides as an Artifact of in Vitro Drug Metabolism Incubations. Drug Metabolism and Disposition 37:8, pages 1581-1586.
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S.C. Mitchell. (1994) The Toxicity of Phenothiazine. Drug Metabolism and Drug Interactions 11:3.
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Jessica H. Bayless, Joseph E. Jablonski, S.M. Roach & Paul D. Sullivan. (1986) Inhibition of the mutagenicity and metabolism of 6-methyl-benzo[a]pyrene and 6-hydroxymethyl-benzo[a]pyrene. Biochemical Pharmacology 35:14, pages 2313-2322.
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David S. Blanchard, M.Danny Burke & Terry C. Orton. (1983) A TLC fluorescence derivatization assay for chlorpromazine and its non-conjugated hepatic microsomal metabolites. Journal of Pharmaceutical and Biomedical Analysis 1:2, pages 195-203.
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Ronald P. Mason. 1982. Free Radicals in Biology. Free Radicals in Biology 161 222 .
A. L. Burlingame, Thomas A. Baillie, Peter J. Derrick & O. S. Chizhov. (2002) Mass spectrometry. Analytical Chemistry 52:5, pages 214-258.
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