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Xenobiotica
the fate of foreign compounds in biological systems
Volume 8, 1978 - Issue 7
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Research Article

Liver and Kidney Damage Induced by N-Hydroxyparacetamol

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Pages 403-411 | Received 20 Sep 1977, Published online: 22 Sep 2008

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Read on this site (6)

N. P. E. Vermeulen, J. G. M. Bessems & R. Van De Straat. (1992) Molecular Aspects of Paracetamol-Induced Hepatotoxicity and its Mechanism-Based Prevention. Drug Metabolism Reviews 24:3, pages 367-407.
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Björn Lindeke. (1982) The Non-and Postenzymatic Chemistry of N-Oxygenated Molecules. Drug Metabolism Reviews 13:1, pages 71-121.
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David Briggs, I. Calder, R. Woods & J. Tange. (1982) The Influence of Metabolic Variation on Analgesic Nephrotoxicity. Experiments with the Gunn Rat. Pathology 14:4, pages 349-353.
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Ian C. Calder, S. J. Hart, M. C. Smail & J. D. Tange. (1981) Hepatotoxicity of Phenacetin and Paracetamol in the Gunn Rat. Pathology 13:4, pages 757-762.
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Denise Godeneche, J. F. Pilichowski & G. Meyniel. (1980) Disposition in rats and mice of chloropractolol, a new β-blocking agent. Xenobiotica 10:9, pages 725-733.
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R. Elbers, H. G. Kampffmeyer & H. Rabes. (1980) Effects and metabolic pathway of 4-dimethylaminophenol during kidney perfusion. Xenobiotica 10:7-8, pages 621-632.
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Articles from other publishers (23)

William M. Lee. (2020) Acetaminophen Toxicity: A History of Serendipity and Unintended Consequences. Clinical Liver Disease 16:S1, pages 34-44.
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Moreno Paolini & Giorgio Cantelli-Forti. 2000. Handbook of Oxidants and Antioxidants in Exercise. Handbook of Oxidants and Antioxidants in Exercise 1021 1051 .
Terrence J. Monks & Serrine S. Lau. (1988) Reactive intermediates and their toxicological significance. Toxicology 52:1-2, pages 1-53.
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L. A. Skoglund, K. Ingebrigtsen, I. Nafstad & J. Høgset Jansen. (2006) Time development of distribution and toxicity following single toxic APAP doses in male BOM:NMRI mice. Journal of Applied Toxicology 7:1, pages 1-6.
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Jørn A. Holme, David C. Dahlin, Sidney D. Nelson & Erik Dybing. (1984) Cytotoxic effects of N-acetyl-p-benzoquinone imine, a common arylating intermediate of paracetamol and N-hydroxyparacetamol. Biochemical Pharmacology 33:3, pages 401-406.
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Jack A. Hinson. (1983) Reactive metabolites of phenacetin and acetaminophen: a review. Environmental Health Perspectives 49, pages 71-79.
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M. A. Henry, R. S. Sweet & J. D. Tange. (2005) A new reproducible experimental model of analgesic nephropathy. The Journal of Pathology 139:1, pages 23-32.
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Marta Hamilton & Peter T. Kissinger. (1982) Determination of acetaminophen metabolites in urine by liquid chromatography/electrochemistry. Analytical Biochemistry 125:1, pages 143-148.
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Jørn A. Holme, Peter J. Wirth, Erik Dybing & Snorri S. Thorgeirsson. (2009) Modulation of N‐Hydroxyparacetamol Cytotoxicity in Suspensions of Isolated Rat Hepatocytes. Acta Pharmacologica et Toxicologica 51:2, pages 96-102.
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Jørn A. Holme, Peter J. Wirth, Erik Dybing & Snorri S. Thorgeirsson. (2009) Cytotoxic Effects of N‐Hydroxyparacetamol in Suspensions of Isolated Rat Hepatocytes. Acta Pharmacologica et Toxicologica 51:2, pages 87-95.
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S. J. Hart, I. C. Calder & J. D. Tange. (1982) The metabolism and toxicity of paracetamol in Sprague-Dawley and wistar rats. European Journal of Drug Metabolism and Pharmacokinetics 7:3, pages 203-222.
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S.J. Hart, R. Tontodonati & I.C. Calder. (1981) Reversed-phase chromatography of urinary metabolites of paracetamol using ion suppression and ion pairing. Journal of Chromatography B: Biomedical Sciences and Applications 225:2, pages 387-405.
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Brian G. Lake, Rosalyn A. Harris, John C. Phillips & Sharat D. Gangolli. (1981) Studies on the effects of l-ascorbic acid on acetaminophen-induced hepatotoxicity. Toxicology and Applied Pharmacology 60:2, pages 229-240.
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Jack A. Hinson, Lance R. Pohl, Terrence J. Monks & James R. Gillette. (1981) Acetaminophen-induced hepatotoxicity. Life Sciences 29:2, pages 107-116.
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J. de Vries. (1981) Hepatotoxic metabolic activation of paracetamol and its derivatives phenacetin and benorilete: Oxygenation or electron transfer?. Biochemical Pharmacology 30:5, pages 399-402.
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Sidney D. Nelson, Anthony J. Forte & David C. Dahlin. (1980) Lack of evidence for N-hydroxyacetaminophen as a reactive metabolite of acetaminophen in vitro. Biochemical Pharmacology 29:11, pages 1617-1620.
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Peter Moldéus & Vera Gergely. (1980) Effect of acetone on the activation of acetaminophen. Toxicology and Applied Pharmacology 53:1, pages 8-13.
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James R. Gillette. 1980. Microsomes, Drug Oxidations and Chemical Carcinogenesis. Microsomes, Drug Oxidations and Chemical Carcinogenesis 777 789 .
Jack A. Hinson, Lance R. Pohl & James R. Gillette. (1980) A simple high-pressure liquid chromatographic assay for the N-hydroxy derivatives of phenacetin, acetaminophen, 2-acetylaminofluorene, and other hydroxamic acids. Analytical Biochemistry 101:2, pages 462-467.
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David J. Miner & Peter T. Kissinger. (1979) Evidence for the involvement of N-ACETYL-p-quinoneimine in acetaminophen metabolism. Biochemical Pharmacology 28:22, pages 3285-3290.
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I.C. Calder, A.C. Yong, R.A. Woods, C.A. Crowe, K.N. Ham & J.D. Tange. (1979) The nephrotoxicity of p-aminophenol. II. The effect of metabolic inhibitors and inducers. Chemico-Biological Interactions 27:2-3, pages 245-254.
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Kay E. Porter & Anthony G. Dawson. (1979) Inhibition of respiration and gluconeogenesis by paracetamol in rat kidney preparations. Biochemical Pharmacology 28:20, pages 3057-3062.
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Jack A. Hinson, Lance R. Pohl & James R. Gillette. (1979) N-hydroxyacetaminophen: A microsomal metabolite of N-hydroxyphenacetin but apparently not of acetaminophen. Life Sciences 24:23, pages 2133-2138.
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