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Xenobiotica
the fate of foreign compounds in biological systems
Volume 8, 1978 - Issue 7
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Research Article

Identification of Three Sulphur-containing Urinary Metabolites of Styrene in the Rat

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Pages 413-418 | Received 13 Jul 1977, Published online: 22 Sep 2008

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Pavel Vodicka, Mikko Koskinen, Alessio Naccarati, Barbara Oesch-Bartlomowicz, Ludmila Vodickova, Kari Hemminki & Franz Oesch. (2006) Styrene Metabolism, Genotoxicity, and Potential Carcinogenicity. Drug Metabolism Reviews 38:4, pages 805-853.
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Igor Linhart. (2001) Stereochemistry of styrene biotransformation*. Drug Metabolism Reviews 33:3-4, pages 353-367.
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I. Linhart, Z. Weidenhoffer, P. Sedmera, M. Polášek & J. Šmejkal. (1996) Biotransformation of diethenylbenzenes, V. Identification of urinary metabolites of 1,2-diethenylbenzene in the rat. Xenobiotica 26:12, pages 1263-1272.
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Susan Jenkins Sumner & Timothy R. Fennell. (1994) Review of the Metabolic Fate of Styrene. Critical Reviews in Toxicology 24:sup1, pages S11-S33.
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I. Linhart, J. Mitera, M. Vosmanská, J. Šmejkal & P. Pech. (1992) Biotransformation of diethenylbenzenes. III: Identification of metabolites of 1,3-diethenylbenzene in rat. Xenobiotica 22:3, pages 335-343.
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Sylvie Décarie & Saroj Chakrabarti. (1989) Metabolism and hepatorenal toxicity due to repeated exposure to styrene in spontaneously hypertensive rats (SHR). Journal of Toxicology and Environmental Health 27:4, pages 455-465.
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James A. Bond & Hermann M. Bolt. (1989) Review of The Toxicology of Styrene. CRC Critical Reviews in Toxicology 19:3, pages 227-249.
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I. Linhart, V. Hanuš, J. Novák, J. Šmejkal & P. Pech. (1989) Biotransformation of Diethenylbenzenes. I. Identification of the Main Urinary Metabolites of 1,4-Diethenylbenzene in the Rat. Xenobiotica 19:6, pages 645-653.
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G. D. Paulson, G. L. Lamoureux & V. J. Feil. (1982) Advances in methods and techniques for the identification of Xeno-biotic conjugates. Journal of Toxicology: Clinical Toxicology 19:6-7, pages 571-608.
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L. P. C. Delbressine, P. J. Van Bladeren, F. L. M. Smeets & F. Seutter-Berlage. (1981) Stereoselective oxidation of styrene to styrene oxide in rats as measured by mercapturic acid excretion. Xenobiotica 11:9, pages 589-594.
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L. P. C. Delbressine, F. Seutter-Berlage & E. Seutter. (1981) Identification of urinary mercapturic acids formed from acrylate, methacrylate and crotonate in the rat. Xenobiotica 11:4, pages 241-247.
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L. P. C. Delbressine, H. C. J. Ketelaars, F. Seutter-Berlage & F. L. M. Smeets. (1980) Phenaceturic acid, a new urinary metabolite of styrene in the rat. Xenobiotica 10:5, pages 337-342.
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F. Seutter-berlage, L. P. C. Delbressine, F. L. M. Smeets & M. A. P. Wagenaars-zegers. (1979) Mechanism of formation of mercapturic acids from (1-bromoethyl)benzene and (2-bromoethyl)benzene in the rat. Xenobiotica 9:5, pages 311-316.
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Articles from other publishers (49)

Gerhard Scherer, Nikola Pluym & Max Scherer. (2022) Comparison of urinary mercapturic acid excretions in users of various tobacco/nicotine products. Drug Testing and Analysis 15:10, pages 1107-1126.
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Yu-Syuan Luo, Hsin-Yun Tsai, Hsin-Chang Chen, Charlene Wu, Li-Ching Shen, Wen-Sheng Chung, Su-Yin Chiang & Kuen-Yuh Wu. (2015) Study of urinary 2-{[2-(acetylamino-2-carboxyethyl]sulfanyl}butanedioic acid, a mercapturic acid of rats treated with maleic acid. Toxicology Letters 236:3, pages 131-137.
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M. Reska, E. Ochsmann, T. Kraus & T. Schettgen. (2010) Accurate quantification of mercapturic acids of styrene (PHEMAs) in human urine with direct sample injection using automated column-switching high-performance liquid chromatography coupled with tandem mass spectrometry. Analytical and Bioanalytical Chemistry 397:8, pages 3563-3574.
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Gary P. Carlson, Meredith Turner & Nancy A. Mantick. (2006) Effects of styrene and styrene oxide on glutathione-related antioxidant enzymes. Toxicology 227:3, pages 217-226.
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Paola Manini, Roberta Andreoli, Diana Poli, Giuseppe De Palma, Antonio Mutti & Wilfried M. A. Niessen. (2002) Liquid chromatography/electrospray tandem mass spectrometry characterization of styrene metabolism in man and in rat. Rapid Communications in Mass Spectrometry 16:24, pages 2239-2248.
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Luigi Perbellini, Nello Veronese & Andrea Princivalle. (2002) Mercapturic acids in the biological monitoring of occupational exposure to chemicals. Journal of Chromatography B 781:1-2, pages 269-290.
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Paola Manini, Roberta Andreoli, Enrico Bergamaschi, Giuseppe De Palma, Antonio Mutti & Wilfried M. A. Niessen. (2000) A new method for the analysis of styrene mercapturic acids by liquid chromatography/electrospray tandem mass spectrometry. Rapid Communications in Mass Spectrometry 14:21, pages 2055-2060.
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Ginette Truchon, Denis Bégin, Jacques Lesage, Mark Goldberg, Diane Talbot, Daniel Drolet & Michel Gérin. (2006) Urinary Excretion of Thioethers Related to Styrene Exposure. Journal of Occupational Health 40:4, pages 350-355.
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Saroj K. Chakrabarti, Claude Denniel, M.Anwar Malick & Chengjiang Bai. (1998) S-[(1 and 2)-Phenyl-2-hydroxyethyl]cysteine-Induced Alterations in Renal Mitochondrial Function in Male Fischer-344 Rats. Toxicology and Applied Pharmacology 151:1, pages 123-134.
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Ali E Karakaya, Bensu Karahalil, Meltem Yılmazer, Neslihan Aygün, Semra Şardaş & Sema Burgaz. (1997) Evaluation of genotoxic potential of styrene in furniture workers using unsaturated polyester resins. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 392:3, pages 261-268.
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L. Maestri, M. Imbriani, S. Ghittori, E. Capodaglio, F. Gobba & A. Cavalleri. (1997) Excretion of N-acetyl-S-(1-phenyl-2-hydroxyethyl)-cysteine and N-acetyl-S-(2-phenyl-2-hydroxyethyl)-cysteine in workers exposed to styrene. Science of The Total Environment 199:1-2, pages 13-22.
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Igor Linhart, Zdeněk Weidenhoffer, Jaroslav Mráz, Jaroslav Šmejkal & Ivana Miládková. (1997) The evidence for conjugated mandelic and phenylglyoxylic acids in the urine of rats dosed with styrene. Toxicology Letters 90:2-3, pages 199-205.
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Luciano Maestri, Sergio Ghittori & Marcello Imbriani. (1996) Determination of urinary mercapturic acids of styrene in man by high-performance liquid chromatography with fluorescence detection. Journal of Chromatography B: Biomedical Sciences and Applications 687:2, pages 387-394.
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Xiao-Xiang Zhang, Saroj Chakrabarti, M.Anwar Malick & Claude-Lise Richer. (1993) Cytogenotoxicity of N-acetyl-S-(-phenyl-2-hydroxyethyl)-cysteine (NAPEC) in cultured human blood lymphocytes. Mutation Research/Genetic Toxicology 319:2, pages 121-127.
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Mayo Uziel, Nancy B. Munro, D. Sue Katz, Tuan Vo-Dinh, Elaine A. Zeighami, Michael D. Waters & Jack D. Griffith. (1992) DNA adduct formation by 12 chemicals with populations potentially suitable for molecular epidemiological studies. Mutation Research/Reviews in Genetic Toxicology 277:1, pages 35-90.
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Åke Norström, Agneta Löf, Leif Aringer, Robert Samuelsson, Barbro Andersson, Jan-Olof Levin & Per Näslund. (1992) Determination of N-acetyl-S-(2-phenyl-2-hydroxyethyl)cysteine in human urine after experimental exposure to styrene. Chemosphere 24:11, pages 1553-1561.
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Leif Aringer, Agneta L�f & Carl-Gustaf Elinder. (1991) The applicability of the measurement of urinary thioethers. International Archives of Occupational and Environmental Health 63:5, pages 341-346.
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Saroj Chakrabarti & Mohammad Anwar Malick. (1991) In vivo nephrotoxic action of an isomeric mixture of S-(1-phenyl-2-hydroxyethyl)glutathione and S(2-phenyl-2-hydroxyethyl)glutathione in Ficher-344 rats. Toxicology 67:1, pages 15-27.
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Igor Linhart & Jaromír Novák. (1990) Biotransformation of diethenylbenzenes. Journal of Chromatography B: Biomedical Sciences and Applications 530, pages 283-294.
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Hiratsuka Akira, Yokoi Akihiro, Iwata Hiroshi, Watabe Tadashi, Satoh Kimihiko, Hatayama Ichiro & Sato Kiyomi. (1989) Glutathione conjugation of styrene 7,8-oxide enantiomers by major glutathione transferase isoenzymes isolated from rat livers. Biochemical Pharmacology 38:24, pages 4405-4413.
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Toshimasa Toyo'oka, Takashi Suzuki, Yukio Saito & Atsushi Takahashi. (1989) Electrochemical detection of mercapturic acid derivatives after separation by high-performance liquid chromatography. Journal of Chromatography A 475:2, pages 391-399.
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M Ikeda. (2016) Determination of Metabolites (Including Thioethers) of Mutagens and/or Carcinogens as Exposure Indicators. Asia Pacific Journal of Public Health 1:2, pages 32-38.
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