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Xenobiotica
the fate of foreign compounds in biological systems
Volume 9, 1979 - Issue 1
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Original Article

Metabolism of Some Kava Pyrones in the Rat

Anna K. Rasmussen Department of Pharmacology, School of Medicine, University of Bergen, 5016, Haukeland Sykehus, Bergen, Norway
,
Ronald R. Scheline Department of Pharmacology, School of Medicine, University of Bergen, 5016, Haukeland Sykehus, Bergen, Norway
,
Einar Solheim Department of Pharmacology, School of Medicine, University of Bergen, 5016, Haukeland Sykehus, Bergen, Norway
&
Rudolf Hänsel Institute of Pharmacognosy and Phytochemistry, Free University Berlin, Königin-Luise-Str. 2-4, D-1000, Berlin 33, Germany
Pages 1-16 | Received 15 May 1978, Published online: 30 Sep 2009

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PeterP. Fu, Qingsu Xia, Lei Guo, Hongtao Yu & Po-Chuen Chan. (2008) Toxicity of Kava Kava. Journal of Environmental Science and Health, Part C 26:1, pages 89-112.
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John Cawte. (1986) Parameters of Kava Used as a Challenge to Alcohol. Australian and New Zealand Journal of Psychiatry 20:1, pages 70-76.
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E. Solheim & R. R. Scheline. (1980) Metabolism of alkenebenzene derivatives in the rat III. Elemicin and isoelemicin. Xenobiotica 10:5, pages 371-380.
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Articles from other publishers (35)

Rita B. Soares, Ricardo Jorge Dinis-Oliveira & Nuno G. Oliveira. (2022) An Updated Review on the Psychoactive, Toxic and Anticancer Properties of Kava. Journal of Clinical Medicine 11:14, pages 4039.
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Pengcheng Wang, Junjie Zhu, Amina I. Shehu, Jie Lu, Jing Chen, Xiao-bo Zhong & Xiaochao Ma. (2019) Enzymes and Pathways of Kavain Bioactivation and Biotransformation. Chemical Research in Toxicology 32:7, pages 1335-1342.
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Yi Wang, Shainnel O. Eans, Heather M. Stacy, Sreekanth C. Narayanapillai, Abhisheak Sharma, Naomi Fujioka, Linda Haddad, Jay McLaughlin, Bonnie A. Avery & Chengguo Xing. (2018) A stable isotope dilution tandem mass spectrometry method of major kavalactones and its applications. PLOS ONE 13:5, pages e0197940.
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T. K. LimT. K. Lim. 2016. Edible Medicinal and Non-Medicinal Plants. Edible Medicinal and Non-Medicinal Plants 147 196 .
Fuad Tarbah, Yann Barguil, Claudia M?ller, Annette Rickert, Wolfgang Weinmann, Mohammed Nour, Pascal Kintz & Thomas Daldrup. (2013) Chromatographic hair analysis for natural kavalactones and their metabolites. A preliminary study. Annales de Toxicologie Analytique 25:3, pages 109-119.
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. 2013. Principles and Practice of Phytotherapy. Principles and Practice of Phytotherapy 353 961 .
Shuang Fu, Anthony Rowe & Iqbal Ramzan. (2012) Kavalactone Metabolism in the Isolated Perfused Rat Liver. Phytotherapy Research 26:12, pages 1813-1816.
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Alexander Vasilev & Steven Vasilev. 2011. Gynecologic Oncology. Gynecologic Oncology 487 507 .
M Ang-Lee & D Basila. 2011. Traditional Chinese Medicine. Traditional Chinese Medicine 5 31 .
Anthony Rowe, Lillian Yuan Zhang & Iqbal Ramzan. (2011) Toxicokinetics of Kava. Advances in Pharmacological Sciences 2011, pages 1-6.
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Michael Balick, Katherine Herrera & Steven Musser. 2010. Encyclopedia of Dietary Supplements, Second Edition. Encyclopedia of Dietary Supplements, Second Edition 459 468 .
X. Z. Li & I. Ramzan. (2009) Role of ethanol in kava hepatotoxicity. Phytotherapy Research 24:4, pages 475-480.
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Michael Ang-Lee, Chun-Su Yuan & Jonathan Moss. 2010. Miller's Anesthesia. Miller's Anesthesia 957 966 .
Caroline N. Lougheed & Moulay Alaoui-Jamali. 2010. Alternative and Complementary Therapies for Cancer. Alternative and Complementary Therapies for Cancer 423 493 .
Valerie Robinson, Wilma F. Bergfeld, Donald V. Belsito, Curtis D. Klaassen, James G. Marks, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder & F. Alan Andersen. (2009) Final Report on the Safety Assessment of Piper Methysticum Leaf/Root/Stem Extract and Piper Methysticum Root Extract. International Journal of Toxicology 28:6_suppl, pages 175S-188S.
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Valerie Robinson, Wilma F. Bergfeld, Donald V. Belsito, Curtis D. Klaassen, James G. MarksJr.Jr., Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder & F. Alan Andersen. (2019) Final Report on the Safety Assessment of Piper Methysticum Leaf/Root/Stem Extract and Piper Methysticum Root Extract . International Journal of Toxicology 28:2_suppl, pages 175S-188S.
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Shuang Fu, Bruce N. Tattam, Colin C. Duke & Iqbal Ramzan. (2009) High-performance liquid chromatography assays for desmethoxyyangonin, methysticin, kavain and their microsomal metabolites. Biomedical Chromatography 23:1, pages 81-91.
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Donald G. Barceloux. 2008. Medical Toxicology of Natural Substances. Medical Toxicology of Natural Substances 525 531 .
James M. Mathews, Amy S. Etheridge, John L. Valentine, Sherry R. Black, Donna P. Coleman, Purvi Patel, James So & Leo T. Burka. (2005) PHARMACOKINETICS AND DISPOSITION OF THE KAVALACTONE KAWAIN: INTERACTION WITH KAVA EXTRACT AND KAVALACTONES IN VIVO AND IN VITRO. Drug Metabolism and Disposition 33:10, pages 1555-1563.
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Steven Musser. 2004. Encyclopedia of Dietary Supplements. Encyclopedia of Dietary Supplements 373 380 .
Wimal Herath, Daneel Ferreira, Julie Rakel Mikell & Ikhlas Ahmad Khan. (2004) Microbial Metabolism. Part 5. Dihydrokawain. CHEMICAL & PHARMACEUTICAL BULLETIN 52:11, pages 1372-1374.
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Benjamin M. Johnson, Sheng-Xiang Qiu, Shide Zhang, Fagen Zhang, Joanna E. Burdette, Linning Yu, Judy L. Bolton & Richard B. van Breemen. (2003) Identification of Novel Electrophilic Metabolites of Piper methysticum Forst. (Kava) . Chemical Research in Toxicology 16:6, pages 733-740.
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James M. Mathews, Amy S. Etheridge & Sherry R. Black. (2002) Inhibition of Human Cytochrome P450 Activities by Kava Extract and Kavalactones. Drug Metabolism and Disposition 30:11, pages 1153-1157.
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J. Gleitz, A. Beile & T. Peters. (1995) (?)-Kavain inhibits veratridine-activated voltage-dependent Na+-channels in synaptosomes prepared from rat cerebral cortex. Neuropharmacology 34:9, pages 1133-1138.
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R. Hänsel & H.-P. Volz. 1995. Neuro-Psychopharmaka Ein Therapie-Handbuch. Neuro-Psychopharmaka Ein Therapie-Handbuch 303 334 .
A. Jussofie, A. Schmiz & C. Hiemke. (1994) Kavapyrone enriched extract fromPiper methysticum as modulator of the GABA binding site in different regions of rat brain. Psychopharmacology 116:4, pages 469-474.
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Claus K?ppel & Joachim Tenczer. (1991) Mass spectral characterization of urinary metabolites of d,l-kawain. Journal of Chromatography B: Biomedical Sciences and Applications 562:1-2, pages 207-211.
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Rudolf HänselRudolf Hänsel. 1991. Phytopharmaka. Phytopharmaka 249 267 .
A.M. Duffield, D.D. Jamieson, R.O. Lidgard, P.H. Duffield & D.J. Bourne. (1989) Identification of some human urinary metabolites of the intoxicating beverage kava. Journal of Chromatography A 475:2, pages 273-281.
Crossref
J. Keledjian, P.H. Duffield, D.D. Jamieson, R.O. Lidgard & A.M. Duffield. (1988) Uptake into Mouse Brain of Four Compounds Present in the Psychoactive Beverage Kava. Journal of Pharmaceutical Sciences 77:12, pages 1003-1006.
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J.E. Cawte. (2015) Kava : A Challenge to Alcohol?. The Aboriginal Child at School 15:2, pages 41-53.
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A. M. Duffield & R. O. Lidgard. (1986) Analysis of kava resin by gas chromatography and electron impact and methane negative ion chemical ionization mass spectrometry. New trace constituents of kava resin. Biological Mass Spectrometry 13:11, pages 621-626.
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A. M. Duffield, R. O. Lidgard & G. K.-C. Low. (1986) Analysis of the constituents ofPiper methysticum by gas chromatography methane chemical ionization mass spectrometry. New constituents of kava resin. Biological Mass Spectrometry 13:6, pages 305-313.
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Rudolf Hänsel & Hans HaasRudolf Hänsel & Hans Haas. 1983. Therapie mit Phytopharmaka. Therapie mit Phytopharmaka 214 242 .
Jan Erik Solbakken, Karsten H. Palmork, Tore Neppelberg & Ronald R. Scheline. (2009) Urinary and Biliary Metabolites of Phenanthrene in the Coalfish ( Pollachius virens ) . Acta Pharmacologica et Toxicologica 46:2, pages 127-132.
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