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Xenobiotica
the fate of foreign compounds in biological systems
Volume 9, 1979 - Issue 1
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Original Article

A Population and Familial Study of the Defective Alicyclic Hydroxylation of Debrisoquine among Egyptians

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Pages 51-56 | Received 30 Jun 1978, Published online: 30 Sep 2009

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G. C. Kahn, M. Rubenfield, D. S. Davies & A. R. Boobis. (1987) Phenacetin O-deethylase activity of the rat: strain differences and the effects of enzyme-inducing compounds. Xenobiotica 17:2, pages 179-187.
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S. I. Islam, J. R. Idle & R. L. Smith. (1980) The polymorphic 4-hydroxylation of debrisoquine in a Saudi arab population. Xenobiotica 10:11, pages 819-825.
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C. Mbanefo, E. A. Bababunmi, A. Mahgoub, T. P. Sloan, J. R. Idle & R. L. Smith. (1980) A study of the debrisoquine hydroxylation polymorphism in a Nigerian population. Xenobiotica 10:11, pages 811-818.
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A. R. Boobis, T. Shiga & R. J. Edwards. 2004. Cardiovascular Pharmacogenetics. Cardiovascular Pharmacogenetics 39 77 .
Takako Shimizu, Hirohide Ochiai, Fredrik Åsell, Hiroshi Shimizu, Ryuta Saitoh, Yoshimasa Hama, Jun Katada, Munehiro Hashimoto, Hitoshi Matsui, Katsuhiko Taki, Tsuguchika Kaminuma, Michiko Yamamoto, Yoshitaka Aida, Akira Ohashi & Naoki Ozawa. (2003) Bioinformatics Research on Inter-racial Difference in Drug Metabolism I. Analysis on Frequencies of Mutant Alleles and Poor Metabolizers on CYP2D6 and CYP2C19. Drug Metabolism and Pharmacokinetics 18:1, pages 48-70.
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Poolsup, Li Wan Po & Knight. (2000) Pharmacogenetics and psychopharmacotherapy. Journal of Clinical Pharmacy and Therapeutics 25:3, pages 197-220.
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E. Spina, G.M. Campo, A. Avenoso, A.P. Caputi, P. Zuccaro, R. Pacifici, G. Gatti, G. Strada, A. Bartoli & E. Perucca. (1994) CYP2D6-related oxidation polymorphism in Italy. Pharmacological Research 29:3, pages 281-289.
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Y. M. Irshaid, H. F. Al-Hadidi & N. M. Rawashdeh. (1993) Dextromethorphan O-demethylation polymorphism in Jordanians. European Journal of Clinical Pharmacology 45:3, pages 271-273.
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A. K. Daly & J. R. Idle. 1993. Cytochrome P450. Cytochrome P450 433 446 .
M. E. Veronese & S. McLean. (1991) Debrisoquine oxidation polymorphism in a Tasmanian population. European Journal of Clinical Pharmacology 40:5, pages 529-532.
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G. Boriarti, E. Strocchi, A. Capucci, S. Boschi, B. Marchesini, E. Ambrosioni & B. Magnani. (2012) Relationships Between Debrisoquine Hydroxylation and Propafenone Pharmacokinetics. Drug Investigation 2:2, pages 114-119.
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S Wanwimolruk, P Patamasucon & EJ Lee. (2012) Evidence for the polymorphic oxidation of debrisoquine in the Thai population.. British Journal of Clinical Pharmacology 29:2, pages 244-247.
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M. Eichelbaum & A.S. Gross. (1990) The genetic polymorphism of debrisoquine/sparteine metabolism — Clinical aspects. Pharmacology & Therapeutics 46:3, pages 377-394.
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De K. Sommers, J. Moncrieff & J. Avenant. (2016) Polymorphism of the 4-Hydroxylation of Debrisoquine in the San Bushmen of Southern Africa. Human Toxicology 7:3, pages 273-276.
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I. Roots, G. Heinemeyer, N. Drakoulis & D. Kampf. 1987. Epidemiological Concepts in Clinical Pharmacology. Epidemiological Concepts in Clinical Pharmacology 105 118 .
JA Critchley, GR Nimmo, CA Gregson, NM Woolhouse & LF Prescott. (1986) Inter-subject and ethnic differences in paracetamol metabolism.. British Journal of Clinical Pharmacology 22:6, pages 649-657.
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W. Kalow. (1986) Genetics of drug transformation. Clinical Biochemistry 19:2, pages 76-82.
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André Barbeau, Madeleine Roy, Suzanne Paris, Thérèse Cloutier, Lorraine Plasse & Judes Poirier. (1985) ECOGENETICS OF PARKINSON'S DISEASE: 4-HYDROXYLATION OF DEBRISOQUINE. The Lancet 326:8466, pages 1213-1216.
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M Jurima, T Inaba, D Kadar & W Kalow. (2012) Genetic polymorphism of mephenytoin p(4′)‐hydroxylation: difference between Orientals and Caucasians.. British Journal of Clinical Pharmacology 19:4, pages 483-487.
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M. Eichelbaum & N. M. Woolhouse. (1985) Inter-ethnic difference in sparteine oxidation among Ghanaians and Germans. European Journal of Clinical Pharmacology 28:1, pages 79-83.
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Claus Hölzel & Gerhard Spiteller. (2006) Piperin – ein Beispiel für individuell unterschiedliche (polymorphe) Metabolisierung einer allgegenwärtigen Nahrungskomponente. Liebigs Annalen der Chemie 1984:7, pages 1319-1331.
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D. M. Roden, T. Wang, R. L. Woosley, A. J. J. Wood, R. A. Branch, A. Küpfer & G. R. Wilkinson. 1984. Pharmacokinetics. Pharmacokinetics 217 234 .
Peter J. Meier, Heinz K. Mueller, Bernhard Dick & Urs A. Meyer. (1983) Hepatic monooxygenase activities in subjects with a genetic defect in drug oxidation. Gastroenterology 85:3, pages 682-692.
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D. B. Jack. (1983) Statistical analysis of polymorphic drug metabolism data using the Rosin Rammler Sperling Weibull distribution. European Journal of Clinical Pharmacology 25:4, pages 443-448.
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Adrian Küpfer, Sabah G. Al-Dabbagh, James C. Ritchie, Jeffrey R. Idle & Robert L. Smith. (1982) Spectral binding studies of the polymorphically metabolized drugs debrisoquine, sparteine and phenformin by cytochrome P-450 of normal and hydroxylation deficient rat strains. Biochemical Pharmacology 31:20, pages 3193-3199.
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J.R. Idle, A. Mahgoub, T.P. Sloan, R.L. Smith, C.O. Mbanefo & E.A. Bababunmi. (1981) Some observations on the oxidation phenotype status of Nigerian patients presenting with cancer. Cancer Letters 11:4, pages 331-338.
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Daniel B Menzel. (1980) Carcinogens and Other Toxic Hazards: How Accurate Are Animal Studies?. Pediatric Annals 9:12, pages 48-56.
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A Bababunmi, JR Idle, A Mahgoub, C Mbanefo & RL Smith. (2012) Polymorphic hydroxylation of debrisoquine in Nigerians [proceedings]. British Journal of Clinical Pharmacology 9:1.
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